Attenuation of the seizure‐induced expression of BDNF mRNA in adult rat brain by an inhibitor of calcium/calmodulin‐dependent protein kinases

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

1995 • 1,429 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

1991 • 578 citations

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

1992 • 564 citations

cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.

1991 • 552 citations

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

1992 • 515 citations

Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II

1993 • 437 citations

Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes

1992 • 412 citations

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences.

1988 • 404 citations

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

1992 • 386 citations

Calcium regulation of gene expression in neuronal cells

1994 • 327 citations

Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus

1988 • 309 citations

Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity

1994 • 297 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

1987 • 287 citations

Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways

1993 • 286 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

1993 • 248 citations

Contrasting patterns in the localization of glutamic acid decarboxylase and Ca2+ /calmodulin protein kinase gene expression in the rat centrat nervous system

1992 • 193 citations

Activation of Ca2+/calmodulin-dependent protein kinase II and protein kinase C by glutamate in cultured rat hippocampal neurons.

1992 • 192 citations

Phosphorylation of AMPA-type glutamate receptors by calcium/calmodulin- dependent protein kinase II and protein kinase C in cultured hippocampal neurons

1994 • 188 citations

Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters

1996 • 166 citations

Differential effects of monocular deprivation on glutamic acid decarboxylase and type II calcium-calmodulin-dependent protein kinase gene expression in the adult monkey visual cortex [published erratum appears in J Neurosci 1991 May;11(5):following Table of Contents]

1991 • 154 citations

Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes.

1994 • 141 citations

[27] Properties and use of H-series compounds as protein kinase inhibitors

1991 • 131 citations

Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus

1992 • 122 citations

Calcium/calmodulin-dependent protein kinase mediates a pathway for transcriptional regulation.

1991 • 120 citations

Brain Insults in Rats Induce Increased Expression of the BDNF Gene through Differential Use of Multiple Promoters

1994 • 113 citations

Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element.

1993 • 112 citations

Calmodulin-dependent protein kinase II

1991 • 110 citations

Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity

1993 • 103 citations

Trophic factor response to neuronal stimuli or injury

1995 • 85 citations

Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: Evidence from lesion and chronic cholinergic drug treatment studies

1993 • 83 citations

Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation

1993 • 68 citations

Association of Phenylthiocarbamide Taste Sensitivity with Diabetes Mellitus in Bangladesh

1994 • 42 citations

A rat brain-derived neurotrophic factor-encoding gene generates multiple transcripts through alternative use of 5′exons and polyadenylation sites

1992 • 35 citations

Decreased expression of the alpha subunit of Ca2+/calmodulin-dependent protein kinase type II rnRNA in the adult rat CNS following recurrent limbic seizures

1995 • 31 citations