Characterization of Ret-Shc-Grb2 Complex Induced by GDNF, MEN 2A, and MEN 2B Mutations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1996 • 711 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

1995 • 336 citations

Loss of function effect of RET mutations causing Hirschsprung disease

1995 • 218 citations

A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 • 188 citations

RET mutations in human disease

1996 • 173 citations

Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

1996 • 132 citations

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

1989 • 130 citations

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

1997 • 123 citations

Identification of Shc docking site on Ret tyrosine kinase

1997 • 117 citations

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

1996 • 112 citations

Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain

1996 • 99 citations

The Men II Syndromes and the Role of the ret Proto-oncogene

1996 • 68 citations

Oncogenic Activation of the ret Protooncogene in Thyroid Cancer

1995 • 50 citations

Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction

1996 • 36 citations

Detection of Ret Homodimers in MEN 2A-Associated Pheochromocytomas

1996 • 10 citations