Structure and subunit composition of GABAA receptors

GABA_A Receptor Channels

1994 • 1,948 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

1992 • 1,525 citations

Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

1995 • 1,277 citations

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

1998 • 1,204 citations

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum

1992 • 673 citations

Electrophysiology of GABAA and GABAB receptor subtypes

1988 • 645 citations

The effect of subunit composition of rat brain GABAA receptors on channel function

1990 • 592 citations

Functional properties of recombinant rat GABAA receptors depend upon subunit composition

1990 • 557 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Functional domains of GABAA receptors

1995 • 485 citations

Stoichiometry and Assembly of a Recombinant GABA_AReceptor Subtype

1997 • 464 citations

Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina.

1991 • 426 citations

Stoichiometry of a Recombinant GABA_AReceptor

1996 • 423 citations

Quaternary Structure of the Native GABA_A Receptor Determined by Electron Microscopic Image Analysis

1994 • 423 citations

GABA _A receptor subtypes: from pharmacology to molecular biology

1991 • 421 citations

Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

1997 • 402 citations

Comparative molecular neuroanatomy of cloned GABA_Areceptor subunits in the rat CNS

1992 • 382 citations

Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies.

1992 • 346 citations

Assembly of GABAA receptor subunits: role of the delta subunit

1994 • 335 citations

Assembly and Cell Surface Expression of Heteromeric and Homomeric γ-Aminobutyric Acid Type A Receptors

1996 • 323 citations

Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic Autoradiography

1971 • 303 citations

Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.

1991 • 294 citations

GABA and Epileptogenesis

1997 • 269 citations

Transient Expression Shows Ligand Gating and Allosteric Potentiation of GABA _A Receptor Subunits

1988 • 233 citations

A Novel Class of GABAA Receptor Subunit in Tissues of the Reproductive System

1997 • 224 citations

Assembly of GABAA receptor subunits: alpha 1 beta 1 and alpha 1 beta 1 gamma 2S subunits produce unique ion channels with dissimilar single- channel properties

1993 • 221 citations

GABAA receptors display association of γ2-subunit with α1- and β2/3-subunits

1991 • 218 citations

Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA_AReceptor Subunit Conferring Atypical Functional Properties

1997 • 209 citations

Single Subunits of the GABA _A Receptor Form Ion Channels with Properties of the Native Receptor

1988 • 193 citations

Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits.

1998 • 193 citations

Ion-channel assembly.

1995 • 181 citations

GABAA receptor modulation of memory: the role of endogenous benzodiazepines

1991 • 179 citations

The γ2 Subunit of the GABA A Receptor is Concentrated in Synaptic Junctions Containing the α1 and β 23 Subunits in Hippocampus, Cerebellum and Globus Pallidus

1996 • 179 citations

Subunit Composition and Quantitative Importance of Hetero-oligomeric Receptors: GABA_AReceptors Containing α₆Subunits

1998 • 175 citations

GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by alpha 5- and delta-subunit-specific immunopurification.

1993 • 170 citations

GABAergic neurons and GABAA-receptors in temporal lobe epilepsy

1999 • 169 citations

Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification

1993 • 164 citations

Formation of heteromeric gamma-aminobutyric acid type A receptors containing two different alpha subunits.

1994 • 143 citations

Ion-channel assembly

1995 • 143 citations

Subcellular localization of gamma-aminobutyric acid type A receptors is determined by receptor beta subunits.

1996 • 141 citations

Molecular composition of GABAC receptors

1998 • 131 citations

GABA_C receptor ρ subunits are heterogeneously expressed in the human CNS and form homo‐ and heterooligomers with distinct physical properties

1999 • 124 citations

Pharmacological and Physiological Characterization of Murine Homomeric β3 GABA_A Receptors

1997 • 123 citations

Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital.

1995 • 114 citations

A Significant Part of Native γ-Aminobutyric AcidAReceptors Containing α4 Subunits Do Not Contain γ or δ Subunits

1999 • 110 citations

Treatment strategies for senile dementia: antagonist β-carbolines

1988 • 103 citations

Immunoaffinity purification of GABAA receptor alpha-subunit iso-oligomers. Demonstration of receptor populations containing alpha 1 alpha 2, alpha 1 alpha 3, and alpha 2 alpha 3 subunit pairs.

1991 • 102 citations

The GABA-A receptor gene family: new targets for therapeutic intervention

1999 • 101 citations

Distribution of GABA_A and GABA_B receptors in mammalian brain: Potential targets for drug development

1990 • 96 citations

Modulation by general anaesthetics of rat GABA_A receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells

1997 • 95 citations

Characterisation of δ-subunit containing GABAA receptors from rat brain

1995 • 94 citations

The neuroanatomical basis of anxiety

1992 • 94 citations

Nicotinic receptor: an allosteric protein specialized for intercellular communication

1995 • 93 citations

The Subunit Composition of a GABA_A/Benzodiazepine Receptor from Rat Cerebellum

1994 • 89 citations

Homomeric beta 1 gamma-aminobutyric acid A receptor-ion channels: evaluation of pharmacological and physiological properties.

1996 • 85 citations

Chloride Channel Expression with the Tandem Construct of α6-β2 GABAA Receptor Subunit Requires a Monomeric Subunit of α6 or γ2

1995 • 80 citations

The rat β₁ ‐subunit of the GABA_A receptor forms a picrotoxin‐sensitive anion channel open in the absence of GABA

1989 • 76 citations

Coexistence of Two β Subunit Isoforms in the Same γ-Aminobutyric Acid Type A Receptor

1997 • 70 citations

gamma-Aminobutyric acid type A receptors in the rat brain can contain both gamma 2 and gamma 3 subunits, but gamma 1 does not exist in combination with another gamma subunit.

1994 • 68 citations

More Than one Alpha Variant May Exist in a Gaba_A/benzodiazepine Receptor Complex

1991 • 63 citations

Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABA_A receptor

1993 • 58 citations

Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors.

1994 • 57 citations

Altering the mammalian circadian clock with the short-acting benzodiazepine, triazolam

1988 • 56 citations

The neurochemistry of anxiety: An update

1990 • 54 citations

Isolation of type I and type II GABA_A‐benzodiazepine receptors by immunoaffinity chromatography

1991 • 48 citations

Functional properties of recombinant GABAA receptors composed of single or multiple β subunit subtypes

1997 • 45 citations

Pharmacological and Electrophysiological Properties of Recombinant GABA_A Receptors Comprising the α3, β1 and γ2 Subunits

1992 • 43 citations

Double-immunolabelling analysis of GABAA receptor subunits in label-fracture replicas of cultured rat cerebellar granule cells.

1994 • 38 citations

The GABA_A receptor channel mediated chloride ion translocation through the plasma membrane: New insights from ³⁶Cl⁻ ion flux measurements

1993 • 29 citations

Identification of subunits mediating clustering of GABAA receptors by rapsyn

1999 • 20 citations

Subunit Stoichiometry of Oligomeric Membrane Proteins: GABA A Receptors Isolated by Selective Immunoprecipitation from the Cell Surface

1996 • 18 citations

Benzodiazepines and appetite: Recent pre-clinical advances and their clinical implications

1989 • 14 citations