The maturase encoded by a group I intron from Aspergillus nidulans stabilizes RNA tertiary structure and promotes rapid splicing 1 1Edited by D. E. Draper

Enzyme structure and mechanism

1977 • 2,935 citations

Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

1996 • 1,240 citations

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

Probing the structure of RNAs in solution

1987 • 721 citations

RNA Chaperones and the RNA Folding Problem

1995 • 702 citations

Structural Features that Give Rise to the Unusual Stability of RNA Hairpins Containing GNRA Loops

1991 • 620 citations

Enzyme Structure and Mechanism

1978 • 573 citations

Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron

1980 • 477 citations

Group I introns as mobile genetic elements: Facts and mechanistic speculations — a review

1989 • 473 citations

Homing endonucleases: keeping the house in order

1997 • 466 citations

Defining the Inside and Outside of a Catalytic RNA Molecule

1989 • 368 citations

RNA Folding at Millisecond Intervals by Synchrotron Hydroxyl Radical Footprinting

1998 • 368 citations

Frequent use of the same tertiary motif by self-folding RNAs.

1995 • 354 citations

Visualizing the Higher Order Folding of a Catalytic RNA Molecule

1991 • 354 citations

Kinetic Intermediates in RNA Folding

1994 • 306 citations

New loop-loop tertiary interactions in self-splicing introns of subgroup IC and ID: a complete 3D model of the Tetrahymena thermophila ribozyme

1996 • 291 citations

Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix

1994 • 276 citations

A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof

1987 • 265 citations

GAAA Tetraloop and Conserved Bulge Stabilize Tertiary Structure of a Group I Intron Domain

1994 • 246 citations

Involvement of a GNRA tetraloop in long-range RNA tertiary interactions

1994 • 241 citations

Involvement of aminoacyl-tRNA synthetases and other proteins in group I and group II intron splicing

1990 • 234 citations

Conformational changes of transfer ribonucleic acid. Equilibrium phase diagrams

1972 • 228 citations

A bacterial group II intron encoding reverse transcriptase, maturase, and DNA endonuclease activities: biochemical demonstration of maturase activity and insertion of new genetic information within the intron

1997 • 219 citations

An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme

1993 • 214 citations

Kinetic Intermediates Trapped by Native Interactions in RNA Folding

1998 • 209 citations

18 Group I and Group II Ribozymes as RNPs: Clues to the Past and Guides to the Future

1999 • 194 citations

Hammerhead ribozyme kinetics

1998 • 190 citations

Folding intermediates of a self-splicing RNA: mispairing of the catalytic core

1998 • 188 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

Rules for RNA recognition of GNRA tetraloops deduced by invitro selection: comparison with invivo evolution

1997 • 186 citations

Escherichia coli proteins, including ribosomal protein S12, facilitate in vitro splicing of phage T4 introns by acting as RNA chaperones.

1994 • 168 citations

Assembly of a Ribonucleoprotein Catalyst by Tertiary Structure Capture

1996 • 142 citations

Protein-facilitated RNA folding

1997 • 117 citations

A Tyrosyl-tRNA Synthetase Protein Induces Tertiary Folding of the Group I Intron Catalytic Core

1996 • 110 citations

The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding

1996 • 109 citations

The fate of an intervening sequence RNA: Excision and cyclization of the Tetrahymena ribosomal RNA intervening sequence in vivo

1983 • 102 citations

Kinetic Mechanism of the Hairpin Ribozyme

1997 • 96 citations

Two major tertiary folding transitions of the Tetrahymena catalytic RNA.

1994 • 94 citations

RNA splicing in Neurospora mitochondria

1985 • 90 citations

[1] Transient kinetic approaches to enzyme mechanisms

1995 • 86 citations

CBP2 protein promotes in vitro excision of a yeast mitochondrial group I intron.

1989 • 85 citations

Dynamics of Thermal Motions within a Large Catalytic RNA Investigated by Cross-linking with Thiol−Disulfide Interchange

1997 • 69 citations

Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron

1995 • 68 citations

A protein encoded by a group I intron in Aspergillus nidulans directly assists RNA splicing and is a DNA endonuclease

1997 • 64 citations

Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks.

1996 • 62 citations

Conformational Transitions of an Unmodified tRNA: Implications for RNA Folding

1998 • 56 citations

Function of P11, a tertiary base pairing in self-splicing introns of subgroup IA

1991 • 56 citations

Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis

1985 • 56 citations

Comparison of pH Dependencies of the Tetrahymena Ribozyme Reactions with RNA 2'-Substituted and Phosphorothioate Substrates Reveals a Rate-Limiting Conformational Step

1994 • 55 citations

The time dependence of chemical modification reveals slow steps in the folding of a group I ribozyme

1995 • 51 citations

4 Homing Endonucleases

1993 • 50 citations

Involvement of Neurospora mitochondrial tyrosyl-tRNA synthetase in RNA splicing. A new method for purifying the protein and characterization of physical and enzymic properties pertinent to splicing

1995 • 39 citations

Crystal structure of domain E of Thermus flavus 5S rRNA: a helical RNA structure including a hairpin loop

1998 • 37 citations

Analysis of the CYT-18 Protein Binding Site at the Junction of Stacked Helices in a Group I Intron RNA by Quantitative Binding Assays andin vitroSelection

1996 • 36 citations

Catalysis of RNA Cleavage by a Ribozyme Derived from the Group I Intron of Anabaena Pre-tRNALeu

1994 • 33 citations

Protein-induced Folding of a Group I Intron in Cytochrome b Pre-mRNA

1995 • 24 citations

Cotranscriptional Splicing of a Group I Intron Is Facilitated by the Cbp2 Protein

1995 • 21 citations

Important 2'-hydroxyl groups within the core of a group I intron

1993 • 17 citations

Self-splicing activity of the mitochondrial group-I introns from Aspergillus nidulans and related introns from other species

1997 • 15 citations

The Conserved Terminal Guanosine of a Group I Intron can Help Prevent Reopening of the Ligated Exons

1993 • 6 citations

pH dependence of self-splicing by the group IA2 intron in a pre-mRNA derived from the nrdB gene of bacteriophage T4

1997 • 3 citations