Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3′:5′-cyclic monophosphate

Adenyl Cyclase

1962 • 853 citations

On the Evaluation of the Constants V _m and K _M in Enzyme Reactions

1952 • 746 citations

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

1976 • 694 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

Regulation in Metabolism

1974 • 607 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates

1975 • 465 citations

The activities of phosphorylase, hexokinase, phosphofructokinase, lactate dehydrogenase and the glycerol 3-phosphate dehydrogenase in muscles from vertebrates and invertebrates

1972 • 382 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

An effect of insulin on adipose-tissue adenosine 3′:5′-cyclic monophosphate phosphodiesterase

1970 • 346 citations

Adenyl Cyclase in Cardiac Tissue

1970 • 304 citations

Hydrolysis of Cyclic Guanosine and Adenosine 3',5'-Monophosphates by Rat and Bovine Tissues

1970 • 303 citations

Characterization of Cyclic Nucleotide Phosphodiesterases of Rat Tissues

1971 • 297 citations

Properties of Cyclic 3',5'-Nucleotide Phosphodiesterase from Rat Brain^*

1967 • 297 citations

Separate Phosphodiesterases for the Hydrolysis of Cyclic Adenosine 3′,5′-Monophosphate and Cyclic Guanosine 3′,5′-Monophosphate in Rat Liver

1973 • 230 citations

Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex.

1968 • 224 citations

Cyclic AMP and Aclrenergic Receptor Control of Rat Liver Glycogen Metabolism

1972 • 214 citations

Effects of Electrical Stimulation and Epinephrine on Muscle Phosphorylase, Phosphorylase b Kinase, and Adenosine 3‘,5‘-Phosphate

1965 • 211 citations

CYCLIC AMP AND SMOOTH MUSCLE FUNCTION*

1971 • 203 citations

The effect of epinephrine and other agents on adenyl cyclase in the cell membrane of avian erythrocytes

1966 • 196 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator

1975 • 170 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 170 citations

A method for deriving kinetic constants for two enzymes acting on the same substrate

1971 • 165 citations

Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats☆

1974 • 163 citations

Adenylate Cyclase in Skeletal Muscle

1972 • 161 citations

Detergent-dispersed Adenylate Cyclase from Rat Brain

1973 • 155 citations

Purification and Properties of 3',5'-Cyclic Nucleotide Phosphodiesterase from Dog Heart^*

1966 • 154 citations

THE MEASUREMENT OF CYCLIC ADENYLATE IN TISSUES

1964 • 152 citations

Adenyl Cyclase of Rat Cerebral Cortex

1971 • 151 citations

Cyclic AMP stimulation of calcium efflux from kidney, liver, and heart mitochondria

1974 • 133 citations

Glycerol kinase activities in muscles from vertebrates and invertebrates

1969 • 121 citations

Isolation of a Plasma‐Membrane Subfraction from Rat Liver Containing an Insulin‐Sensitive Cyclic‐AMP Phosphodiesterase

1972 • 113 citations

Cyclic nucleotide phosphodiesterases and thyroid hormones.

1975 • 110 citations

Effects of Thyroid Hormone Deficiency on Cyclic Adenosine 3′ : 5′-Monophosphate and Control of Lipolysis in Fat Cells

1974 • 103 citations

The role of potassium and calcium ions in the effect of epinephrine on cardiac cyclic adenosine 3',5'-monophosphate, phosphorylase kinase, and phosphorylase.

1968 • 102 citations

Oscillation of Cyclic Adenosine Monophosphate Concentration during the Myocardial Contraction Cycle

1973 • 100 citations

Effect of glucagon on rat heart adenyl cyclase

1969 • 89 citations

Skeletal Muscle Lipids

1967 • 87 citations

Cyclic Nucleotide Phosphodiesterases

1982 • 86 citations

Effect of Glucagon on Cyclic 3',5'-AMP, Phosphorylase Activity and Contractility of Heart Muscle of the Rat

1970 • 84 citations

Cyclic nucleotides and cellular calcium metabolism.

1975 • 83 citations

Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle

1973 • 82 citations

Protein binding assays for cyclic nucleotides.

1972 • 69 citations

The role of cyclic GMP in the regulation of cyclic AMP hydrolysis

1975 • 69 citations

Cyclic 3′,5′-AMP phosphodiesterase of Neurosporacrassa

1973 • 68 citations

Effects of Epinephrine, Adrenocorticotrophic Hormone, and Theophylline on Adenosine 3′,5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1974 • 68 citations

Catecholamine and Ca2+ Activation of Adenylate Cyclase Systems in Synaptosomal Fractions from Rat Cerebral Cortex

1973 • 68 citations

Cyclic nucleotide phosphodiesterase activities from isolated fat cells: Correlation of subcellular distribution with effects of nucleotides and insulin

1974 • 62 citations

Skeletal Muscle Lipids

1966 • 60 citations

Cyclic adenosine 3′,5′-monophosphate role in the physiology and pharmacology of the central nervous system

1975 • 59 citations

CATECHOLAMINE INDUCED INCREASE OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN RAT BRAIN IN VIVO

1972 • 57 citations

Cyclic GMP.

1973 • 57 citations

Effects of hormones on cyclic AMP release in perfused rat livers

1973 • 55 citations

Regulation of cyclic nucleotide phosphodiesterase.

1975 • 50 citations

Determination of 3′,5′-Adenosine Monophosphate with a Method Based on a Radioactive Phosphate Exchange Reaction

1968 • 46 citations

Activities of hexokinase, phosphofructokinase, 3-oxo acid coenzyme A-transferase and acetoacetyl-coenzyme A thiolase in nervous tissue from vertebrates and invertebrates

1973 • 46 citations

Purification of Adenohypophyseal Plasma Membranes and Properties of Associated Adenylate Cyclase

1974 • 45 citations

The actions of hormones on the adenyl cyclase system.

1970 • 42 citations

Isolation of cyclic 3′,5′-adenosine monophosphate on a neutral silicic acid-glass microfiber matrix

1970 • 35 citations

Bovine adrenal cortical adenyl cyclase and its stimulation by adrenocorticotropic hormone and NaF

1971 • 35 citations

Adenyl cyclase.

1973 • 33 citations

Adenylate cyclase from guinea pig lung: Further characterization and inhibitory effects of substrate analogs and cyclic nucleotides

1973 • 29 citations

Cyclic 3′,5′-AMP phosphodiesterase of human blood lymphocytes

1972 • 28 citations

Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa

1969 • 28 citations

Protein phosphorylation in respiring slices of guinea-pig cerebral cortex. Evidence for a role for noradrenaline and adenosine 3′:5′-cyclic monophosphate in the increased phosphorylation observed on application of electrical pulses

1976 • 26 citations

The use of antibodies to study cell structure and metabolism.

1973 • 24 citations

Epinephrine induced formation of adenosine 3′,5′ -monophosphate in mouse skeletal muscle

1969 • 23 citations

Heat treatment of rat liver adenosine 3′:5′-monophosphate phosphodiesterase

1974 • 19 citations

The relation between adenylate cyclase activation and camp accumulation in the horse thyroid gland stimulated by thyrotropin

1974 • 17 citations

Quantitative aspects of the regulation of cellular cyclic AMP levels

1975 • 14 citations

Consequences of the intracellular distribution of cyclic 3′,5′‐nucleotides phosphodiesterases

1974 • 10 citations

Synthesis and degradation of cyclic 3',5'-adenosine monophosphate in frog erythrocytes.

1970 • 5 citations