Why do cancer cells metastasize into particular organs?

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

Proteoglycans as modulators of growth factor activities

1991 • 1,338 citations

An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion

1989 • 659 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites

1988 • 405 citations

De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis.

1989 • 367 citations

Homing Receptors and Vascular Addressins: Cell Adhesion Molecules that Direct Lymphocyte Traffic

1989 • 332 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver.

1984 • 291 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Role of plasma, platelets, and endothelial cells in tumor metastasis

1984 • 260 citations

Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis

1990 • 253 citations

Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo.

1987 • 250 citations

Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

1990 • 238 citations

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes.

1990 • 213 citations

Identification of an amino acid sequence from the laminin A chain that stimulates metastasis and collagenase IV production.

1990 • 178 citations

Modes of FGF release in vivo and in vitro

1990 • 169 citations

Metastatic behavior of a murine reticulum cell sarcoma exhibiting organ-specific growth.

1981 • 154 citations

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

1987 • 145 citations

Organ specificity of metastatic tumor colonization is related to organ‐selective growth properties of malignant cells

1986 • 145 citations

Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene.

1989 • 141 citations

Organ preference of metastasis. The role of organ-specifically modulated endothelial cells.

1988 • 137 citations

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

1989 • 136 citations

Migration of tumor cells to organ-derived chemoattractants.

1985 • 135 citations

Increased Expression of the Laminin Receptor in Human Colon Cancer

1991 • 123 citations

Promotion of pulmonary metastasis in mice by bleomycin-induced endothelial injury.

1986 • 111 citations

Metastasis Inhibition of Different Tumor Types by Purified Laminin Fragments and a Heparin-Binding Fragment of Fibronectin

1988 • 105 citations

Metastatic potential of murine fibrosarcoma cells is influenced by cell surface laminin

1984 • 96 citations

Liver-colonizing melanoma cells selected from B-16 melanoma

1979 • 93 citations

Private and public autocrine loops in neoplastic cells.

1989 • 90 citations

Inflammatory Oncotaxis

1978 • 82 citations

Analysis of Organ-Specific Effects on Metastatic Tumor Formation by Studies In Vitro<xref ref-type="fn" rid="FN1">2</xref>

1986 • 82 citations

Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells.

1991 • 79 citations

Clonal growth of tumors on tissue-specific biomatrices and correlation with organ site specificity of metastases.

1989 • 72 citations

Homing Receptors and Metastasis

1988 • 71 citations

Resorbing bone stimulates tumor cell growth. A role for the host microenvironment in bone metastasis.

1986 • 67 citations

Adhesive, invasive, and growth properties of selected metastatic variants of a murine large-cell lymphoma.

1989 • 61 citations

Kupffer cells and liver metastasis

1989 • 58 citations

Growth regulation of cancer metastases by their host organ.

1988 • 51 citations

Endothelial cell membrane vesicles in the study of organ preference of metastasis.

1991 • 50 citations

Inhibition of Tumor Cell-Induced Platelet Aggregation and Experimental Tumor Metastasis by the Synthetic Gly-Arg-Gly-Asp-Ser Peptide

1988 • 50 citations

Differential organ tissue adhesion, invasion, and growth properties of metastatic rat mammary adenocarcinoma cells

1988 • 43 citations

The role of tumor-induced platelet aggregation, platelet adhesion and adhesive proteins in tumor metastasis.

1988 • 38 citations

Differential Adhesion of Metastatic Rat Mammary Carcinoma Cells to Organ-Derived Microvessel Endothelial Cells and Subendothelial Matrix

1989 • 37 citations

Chemotactic activity of bone and platelet-derived TGF-beta for bone-metastasizing rat Walker 256 carcinosarcoma cells.

1990 • 29 citations

Organ-specific chemotactic factors present in lung extracellular matrix

1989 • 28 citations

Purification and characterization of a Mr ∼66,000 lung-derived (paracrine) growth factor that preferentially stimulates the in vitro proliferation of lung-metastasizing tumor cells

1990 • 21 citations

Preferential Growth of Blood-Borne Cancer Cells at Sites of Trauma — A Growth Promoting Role of Macrophages

1988 • 19 citations

Metastatic phenotype: growth factor dependence and integrin expression.

1990 • 17 citations

Growth factor modulation of metastatic lung colonization.

1990 • 14 citations

The role of both specific cellular adhesion and growth promotion in liver colonization by F9 embryonal carcinoma cells

1991 • 13 citations

Membrane-anchored growth factors work!

1989 • 9 citations

Partial purification and characterization of hepatocyte proliferation stimulatory factor from liver of pats treated with d-galactosamine

1988 • 8 citations

Variable susceptibility to NK activity of cloned cell lines derived from a primary rat rhabdomyosarcoma: Relationship to metastatic potential

1983 • 7 citations

Nude mouse resists hepatic metastasis of the allogeneic tumor, colon-26

1990 • 5 citations

Differential Susceptibility of Metastatic Lymphoma Cells to Natural Immunity

1990 • 5 citations

Metastatic phenotype: Growth factor dependence and integrin expression

1990 • 3 citations