Membrane-anchored growth factors work!

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Epidermal Growth Factor

1979 • 2,964 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor

1985 • 369 citations

Human epidermal growth factor precursor: cDNA sequence, expressionin vitroand gene organization

1986 • 321 citations

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1987 • 317 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner.

1982 • 137 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations