HLA-E is the only class I gene that escapes CpG methylation and is transcriptionally active in the trophoblast-derived human cell line JAR

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

1990 • 1,417 citations

DNA methylation and gene activity

1988 • 904 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

DNA methylation and gene expression

1991 • 685 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Map of the human MHC

1993 • 585 citations

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

1987 • 515 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule.

1990 • 393 citations

Use of restriction enzymes to detect potential gene sequences in mammalian DNA

1987 • 387 citations

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

1981 • 374 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

Evolution of Class-I MHC Genes and Proteins: From Natural Selection to Thymic Selection

1990 • 286 citations

Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor

1985 • 240 citations

HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

1988 • 239 citations

Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue

1990 • 224 citations

Diversity and diversification of HLA-A,B,C alleles.

1989 • 224 citations

Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.

1990 • 200 citations

Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.

1984 • 187 citations

EXPRESSION OF HLA SYSTEM ANTIGENS ON PLACENTA

1976 • 185 citations

The JAr cell line - continuous human multi-hormone production and controls

1971 • 175 citations

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

1992 • 165 citations

A sex chromosome rearrangement in a human XX male caused by Alu—Alu recombination

1987 • 154 citations

CG dinucleotide clusters in MHC genes and in 5′ demethylated genes

1984 • 146 citations

Structure–function relationships in eukaryotic nuclei

1991 • 138 citations

Regulation of the expression of class I MHC genes.

1990 • 129 citations

Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel Electrophoresis

1987 • 126 citations

Isolation of HLA locus-specific DNA probes from the 3'-untranslated region.

1984 • 120 citations

Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns.

1989 • 109 citations

Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism

1992 • 102 citations

The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

1985 • 96 citations

Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos.

1988 • 89 citations

The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein.

1992 • 81 citations

Demethylation of CpG sites in DNA of early rabbit trophoblast

1981 • 68 citations

Gamma-interferon enhances expression of Class I MHC antigens in the weakly HLA+ human choriocarcinoma cell line BeWo, but does not induce MHC expression in the HLA- choriocarcinoma cell line Jar.

1985 • 61 citations

Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family.

1987 • 58 citations

Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.

1988 • 57 citations

MHC antigens on human tumors

1991 • 56 citations

Gamma interferon and 5-azacytidine cause transcriptional elevation of class I major histocompatibility complex gene expression in K562 leukemia cells in the absence of differentiation.

1986 • 48 citations

DNA methylation prevents transfection of genes for specific surface antigens.

1988 • 46 citations

A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2B13 haplotype) derived from a monosomy 6 mutant cell line

1989 • 46 citations

Differential expression of the HLA class I multigene family by human embryonal carcinoma and choriocarcinoma cell lines.

1990 • 42 citations

A continuous restriction map from HLA-E to HLA-F. Structural comparison between different HLA-A haplotypes

1992 • 41 citations

Expression of HLA-A, -B, and -C and beta 2-microglobulin antigens in human choriocarcinoma cell lines.

1980 • 41 citations

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

1986 • 40 citations

An HLA-C-specific DNA probe

1986 • 38 citations

CpG islands and HTF islands in the HLA class I region: investigation of the methylation status of class I genes leads to precise physical mapping of the HLA-B and -C genes

1988 • 36 citations

Cytosine methylation in gene-silencing mechanisms

1991 • 34 citations

Evasive Strategies of Trophoblast Cells: Selective Expression of Membrane Antigens

1990 • 33 citations

Molecular analysis of the human MHC class I region using yeast artificial chromosome clones

1990 • 33 citations

Choriocarcinoma cells increase the number of differentiating human cytotrophoblasts through an in vitro interaction

1991 • 31 citations

The chromosome region containing the highly polymorphic HLA class I genes displays limited large scale variability in the human population.

1988 • 29 citations

REPRESSION OF CLASS I H‐2K,H‐2D ANTIGENS ON GR9 METHYLCHOLANTHRENE‐INDUCED TUMOUR CELL CLONES IS RELATED TO THE LEVEL OF DNA METHYLATION

1986 • 27 citations

HLA-B locus polymorphism: studies with a specific hybridization probe.

1985 • 26 citations

Limitation of differential expression of HLA-A,B,C antigens on choriocarcinoma cell lines by messenger RNA for HLA heavy chain but not by beta 2-microglobulin.

1984 • 24 citations

Major histocompatibility complex class I genes in murine fibrosarcoma IC9 are down regulated at the level of the chromatin structure.

1989 • 23 citations

Transformation of LMTK- cells with purified class I genes. V. Antibody-induced structural modification of HLA class I molecules results in potentiation of the fixation of a second monoclonal antibody.

1984 • 22 citations

YAC-assisted cloning of a putative G-protein mapping to the MHC class I region

1992 • 19 citations

Regulation of HLA class I transcription in T cells.

1989 • 19 citations

The role of recombinational hotspots in genome instability in mammalian cells

1990 • 19 citations

Identification of collagens synthesized by cultures of normal human corneal and keratoconus stromal cells

1983 • 18 citations

Transfected trophoblast‐derived human cells can express a single HLA class I allelic product

1991 • 16 citations

Megabase scale restriction fragment length polymorphisms in the human major histocompatibility complex

1990 • 16 citations

Gamma Interferon and 5-Azacytidine Cause Transcriptional Elevation of Class I Major Histocompatibility Complex Gene Expression in K562 Leukemia Cells in the Absence of Differentiation

1986 • 15 citations

Binding of nuclear factors to the 5′-interferon consensus sequence of the HLA-A2 class I gene

1990 • 3 citations