Histidine kinases and response regulator proteins in two-component signaling systems

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

2000 • 8,948 citations

Two-Component Signal Transduction

2000 • 3,517 citations

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS

1992 • 1,449 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics

1997 • 1,147 citations

SGD: Saccharomyces Genome Database

1998 • 1,138 citations

Two-Component Signal Transduction

1995 • 752 citations

GHKL, an emergent ATPase/kinase superfamily

2000 • 725 citations

Crystal structure of an N-terminal fragment of the DNA gyrase B protein

1991 • 526 citations

Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.

1992 • 475 citations

Structure of CheA, a Signal-Transducing Histidine Kinase

1999 • 471 citations

Compilation of All Genes Encoding Two-component Phosphotransfer Signal Transducers in the Genome of Escherichia coli

1997 • 384 citations

The Histidine Protein Kinase Superfamily

1999 • 376 citations

Crystal Structure and ATPase Activity of MutL

1998 • 374 citations

Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction

1998 • 356 citations

A genomic analysis of two‐component signal transduction in Streptococcus pneumoniae

2000 • 321 citations

Two-component signal transducers and MAPK cascades

1997 • 288 citations

Genes Encoding Pseudo-Response Regulators: Insight into His-to-Asp Phosphorelay and Circadian Rhythm in Arabidopsis thaliana

2000 • 281 citations

Structural relationships in the OmpR family of winged-helix transcription factors 1 1Edited by M. Gottesman

1997 • 264 citations

The Two-Component System1

1998 • 263 citations

Is acetyl phosphate a global signal in Escherichia coli?

1993 • 257 citations

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ

1998 • 256 citations

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ.

1999 • 234 citations

A tale of two components: a novel kinase and a regulatory switch.

2000 • 218 citations

Structure of the magnesium-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis

1993 • 215 citations

Two-Component Signal Transduction as a Target for Microbial Anti-Infective Therapy

1998 • 210 citations

Conformational changes induced by phosphorylation of the FixJ receiver domain

1999 • 207 citations

Two-component systems in plant signal transduction

2000 • 207 citations

Structure of a transiently phosphorylated switch in bacterial signal transduction

1999 • 199 citations

Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family.

2001 • 195 citations

The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p

1998 • 183 citations

Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain

1998 • 180 citations

Crystal structure of an activated response regulator bound to its target.

2001 • 164 citations

Insights into Multistep Phosphorelay from the Crystal Structure of the C-Terminal HPt Domain of ArcB

1997 • 159 citations

Signalling pathways in two-component phosphorelay systems

1999 • 153 citations

Phosphorylated aspartate in the structure of a response regulator protein 1 1Edited by A. R. Fersht

1999 • 145 citations

Compilation of All Genes Encoding Bacterial Two-component Signal Transducers in the Genome of the Cyanobacterium, Synechocystis sp. Strain PCC 6803

1996 • 144 citations

Defective Hyphal Development and Avirulence Caused by a Deletion of the SSK1 Response Regulator Gene in Candida albicans

2000 • 140 citations

Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators

1999 • 137 citations

Response Regulators CheB and CheY Exhibit Competitive Binding to the Kinase CheA

1995 • 133 citations

NMR structure of activated CheY

2000 • 133 citations

Signal Decay through a Reverse Phosphorelay in the Arc Two-component Signal Transduction System

1998 • 130 citations

Structure of the CheY-binding domain of histidine kinase CheA in complex with CheY

1998 • 129 citations

Expression of CheA fragments which define domains encoding kinase, phosphotransfer, and CheY binding activities

1993 • 117 citations

Formation of a Novel Four-Helix Bundle and Molecular Recognition Sites by Dimerization of a Response Regulator Phosphotransferase

1998 • 108 citations

The two-component hybrid kinase regulator CaNIKl of Candida albicans

1998 • 92 citations

Two binding modes reveal flexibility in kinase/response regulator interactions in the bacterial chemotaxis pathway

1998 • 89 citations

Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1 1 1Edited by I. A. Wilson

1999 • 88 citations

Solution structure of the DNA-binding domain of NtrC with three alanine substitutions 1 1Edited by P. E. Wright

1999 • 83 citations

NMR studies of the phosphotransfer domain of the histidine kinase CheA from Escherichia coli: assignments, secondary structure, general fold, and backbone dynamics

1995 • 79 citations

Flocculation of hyphae is associated with a deletion in the putative CaHK1 two-component histidine kinase gene from Candida albicans

1999 • 79 citations

Histidine kinases and two-component signal transduction systems

1999 • 77 citations

NarL Dimerization? Suggestive Evidence from a New Crystal Form^,

1998 • 71 citations

The 1.9 Å Resolution Crystal Structure of Phosphono-CheY, an Analogue of the Active Form of the Response Regulator, CheY^,

2000 • 67 citations

Kinetic Characterization of CheY Phosphorylation Reactions: Comparison of P-CheA and Small-Molecule Phosphodonors

1999 • 67 citations

Taking the plunge: terminal differentiation in Dictyostelium

1999 • 65 citations

Structure and Dynamics of a CheY-Binding Domain of the Chemotaxis Kinase CheA Determined by Nuclear Magnetic Resonance Spectroscopy^,

1996 • 52 citations

A Phosphotransferase Activity of theBacillus subtilisSporulation Protein Spo0F That Employs Phosphoramidate Substrates

1996 • 49 citations

Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1

2000 • 45 citations

Signal transduction: Gyrating protein kinases

1999 • 35 citations