Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novelMTHFRpolymorphic site, G1793A

Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study

1991 • 3,323 citations

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review

2000 • 1,041 citations

Neural-Tube Defects

1999 • 965 citations

Biological and clinical implications of the MTHFR C677T polymorphism

2001 • 528 citations

A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B12) Increases Risk for Spina Bifida

1999 • 434 citations

PERICONCEPTIONAL VITAMIN USE, DIETARY FOLATE, AND THE OCCURRENCE OF NEURAL TUBE DEFECTS

1995 • 399 citations

Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria

1998 • 386 citations

Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring

1995 • 367 citations

Genetic Predisposition to Hyperhomocysteinemia: Deficiency of Methylenetetrahydrofolate Reductase (MTHFR)

1997 • 358 citations

Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)

1998 • 347 citations

Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects

1999 • 290 citations

The Effects of Folic Acid Supplementation on Plasma Total Homocysteine Are Modulated by Multivitamin Use and Methylenetetrahydrofolate Reductase Genotypes

1997 • 277 citations

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.

1995 • 263 citations

A Common Mutation A1298C in Human Methylenetetrahydrofolate Reductase Gene: Association with Plasma Total Homocysteine and Folate Concentrations

1999 • 258 citations

Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease

1997 • 234 citations

Neonatal and Fetal Methylenetetrahydrofolate Reductase Genetic Polymorphisms: An Examination of C677T and A1298C Mutations

2000 • 223 citations

C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations

1998 • 209 citations

C677T and A1298C Polymorphisms of the Methylenetetrahydrofolate Reductase Gene: Incidence and Effect of Combined Genotypes on Plasma Fasting and Post-Methionine Load Homocysteine in Vascular Disease

2001 • 189 citations

Molecular biology of 5,10-methylenetetrahydrofolate reductase.

2000 • 188 citations

Analysis of the 677 C→T Mutation of the Methylenetetrahydrofolate Reductase Gene in Different Ethnic Groups

1998 • 158 citations

Annotation Molecular genetics of methylenetetrahydrofolate reductase deficiency

1996 • 149 citations

Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.

1996 • 147 citations

The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease

1997 • 139 citations

High Prevalence of the Thermolabile Methylenetetrahydrofolate Reductase Variant in Mexico: A Country with a Very High Prevalence of Neural Tube Defects

1999 • 126 citations

Prevalence of the mutation C677 ? T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil

1998 • 104 citations

Neural Tube Defect Prevalence in California (1990-1994): Eliciting Patterns by Type of Defect and Maternal Race/Ethnicity

1999 • 101 citations

Analysis of select folate pathway genes,PAX3, and humanT in a midwestern neural tube defect population

1999 • 97 citations

Blood folate and vitamin B12: United States, 1988-94.

1998 • 95 citations

Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population

1998 • 89 citations

Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria

2000 • 87 citations

Hispanic Origin and Neural Tube Defects in Houston/Harris County, Texas: II. Risk Factors

1996 • 81 citations

Neural tube defects and a disturbed folate dependent homocysteine metabolism

2000 • 79 citations

Methylenetetrahydrofolate reductase and spina bifida: Evaluation of level of defect and maternal genotypic risk in Hispanics

2000 • 77 citations

Methylenetetrahydrofolate reductase (MTHFR): The incidence of mutations C677T and A1298C in the Ashkenazi Jewish population

1999 • 74 citations

Hispanic Origin and Neural Tube Defects in Houston/Harris County, Texas: I. Descriptive Epidemiology

1996 • 68 citations

Identification of four novel mutations in severe methylenetetrahydrofolate reductase deficiency

1998 • 55 citations

Open or Closed? A World of Difference: A History of Homocysteine Research

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Spontaneous abortion–high risk factor for neural tube defects in subsequent pregnancy

1994 • 42 citations

Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis

2000 • 41 citations

Prevalence of Genetic Mutations That Predispose to Thrombophilia in a Greek Cypriot Population

2000 • 40 citations

Molecular Genetics of Homocysteine Metabolism

1999 • 39 citations

Examinations of Methylenetetrahydrofolate Reductase C677T and A1298C Mutations—and In Utero Viability

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THE DEVELOPMENT OF THE JAPANESE BLOOD-FLUKE, SCHISTOSOMA JAPONICUM KATSURADA, IN ITS FINAL HOST*

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Folate and Its Various Ramifications

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