High Prevalence of the Thermolabile Methylenetetrahydrofolate Reductase Variant in Mexico: A Country with a Very High Prevalence of Neural Tube Defects

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study

1991 • 3,323 citations

Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation

1992 • 3,145 citations

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

1998 • 1,569 citations

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

1998 • 1,283 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.

1981 • 678 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Homocysteine metabolism in pregnancies complicated by neural-tube defects

1995 • 641 citations

Vitamin dificiencies and neural tube defects.

1976 • 580 citations

Periconceptional Folic Acid Exposure and Risk of Occurrent Neural Tube Defects

1993 • 405 citations

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

1981 • 389 citations

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects

1995 • 314 citations

Epidemiology and Control of Neural Tube Defects

1992 • 296 citations

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.

1995 • 263 citations

The “Thermolabile” Variant of Methylenetetrahydrofolate Reductase and Neural Tube Defects: An Evaluation of Genetic Risk and the Relative Importance of the Genotypes of the Embryo and the Mother

1999 • 248 citations

Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis

1997 • 241 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 230 citations

5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects

1996 • 224 citations

Inherited disorders of folate transport and metabolism

1995 • 201 citations

Primary prevention of neural tube defects with folic acid supplementation: Cuban experience

1990 • 190 citations

Analysis of the 677 C→T Mutation of the Methylenetetrahydrofolate Reductase Gene in Different Ethnic Groups

1998 • 158 citations

Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.

1996 • 147 citations

Prevalence of the mutation C677 ? T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil

1998 • 104 citations

MTHFR association with arteriosclerotic vascular disease?

1998 • 100 citations

Analysis of select folate pathway genes,PAX3, and humanT in a midwestern neural tube defect population

1999 • 97 citations

Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland.

1984 • 92 citations

THE INCIDENCE OF THE GENE FOR THERMOLABILE METHYLENE TETRAHYDROFOLATE REDUCTASE IN AFRICAN AMERICANS

1996 • 87 citations

The Role of Folate Transport and Metabolism in Neural Tube Defect Risk

1999 • 65 citations