Clinical Pharmacokinetics of Troglitazone

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

1998 • 798 citations

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

1996 • 654 citations

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 • 638 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Cardiac and Glycemic Benefits of Troglitazone Treatment in NIDDM

1997 • 372 citations

Effect of Troglitazone in Insulin-Treated Patients with Type II Diabetes Mellitus

1998 • 337 citations

Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

1998 • 293 citations

Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients

1996 • 239 citations

Two Cases of Severe Clinical and Histologic Hepatotoxicity Associated with Troglitazone

1998 • 232 citations

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

1997 • 217 citations

Troglitazone-Induced Hepatic Failure Leading to Liver Transplantation: A Case Report

1998 • 198 citations

Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat

1994 • 193 citations

Impaired Glucose Tolerance is Normalized by Treatment With the Thiazolidinedione Troglitazone

1997 • 143 citations

Troglitazone in Combination With Sulfonylurea Restores Glycemic Control in Patients With Type 2 Diabetes

1998 • 140 citations

Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in mice

1991 • 118 citations

Troglitazone Monotherapy Improves Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Randomized, Controlled Study¹

1998 • 115 citations

Effects of troglitazone and metformin on glucose and lipid metabolism

1997 • 110 citations

Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and mice

1995 • 100 citations

Disposition and metabolism of the new oral antidiabetic drug troglitazone in rats, mice and dogs.

1997 • 98 citations

Troglitazone Use in Insulin-Treated Type 2 Diabetic Patients

1998 • 88 citations

Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.

1996 • 86 citations

Acute effects of troglitazone on in vivo insulin action in normal rats

1995 • 55 citations

Steady‐State Pharmacokinetics and Dose Proportionality of Troglitazone and Its Metabolites

1999 • 50 citations

Thiazolidinediones (AD-4833 and CS-045) Improve Hepatic Insulin Resistance in Streptozotocin-Induced Diabetic Rats.

1993 • 49 citations

Lack of Effect of Type II Diabetes on the Pharmacokinetics of Troglitazone in a Multiple‐Dose Study

1997 • 43 citations

POTENTIAL INTERACTION OF TROGLITAZONE AND CYCLOSPORINE

1998 • 34 citations

Effect of troglitazone on urinary excretion of 6beta-hydroxycortisol.

1998 • 33 citations

Pharmacokinetics of troglitazone, a PPAR-γ agonist, in patients with hepatic insufficiency

1998 • 32 citations

Effect of Troglitazone on the Pharmacokinetics of an Oral Contraceptive Agent

1999 • 31 citations

CS-045, a new oral antidiabetic agent, stimulates fructose-2,6-bisphosphate production in rat hepatocytes

1994 • 30 citations

Meta‐Analysis of Steady‐State Pharmacokinetics of Troglitazone and Its Metabolites

1997 • 23 citations

Improvement in the gastrointestinal absorption of troglitazone when taken with, or shortly after, food

1998 • 21 citations

Concomitant administration of cholestyramine influences the absorption of troglitazone

1998 • 15 citations

Effect of Troglitazone on Steady‐State Pharmacokinetics of Digoxin

1998 • 13 citations

Good metabolic and safety profile of troglitazone alone and following alcohol in NIDDM subjects

1997 • 12 citations

Establishing the dose response curve for metabolic control with troglitazone, an insulin action enhancer, in type 2 diabetes patients

1998 • 11 citations

Coadministration of Acetaminophen and Troglitazone: Pharmacokinetics and Safety

1998 • 9 citations

Double-masked, placebo-controlled, dose-ranging study of troglitazone 10 to 200 mg once daily in non—insulin-dependent diabetes mellitus

1997 • 9 citations

Effect of troglitazone on PK and PD of atorvastatin

1999 • 7 citations

Effect of troglitazone on fexofenadine pharmacokinetics

1999 • 4 citations

Pharmacokinetics of Troglitazone in Patients with Renal Insufficiency

1999 • 1 citations