Peripheral Myelin Protein 22 and Protein Zero: a Novel Association in Peripheral Nervous System Myelin

Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin

1985 • 538 citations

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

1992 • 493 citations

Identical point mutations of PMP–22 in Trembler–J mouse and Charcot–Marie–Tooth disease type 1A

1992 • 422 citations

Synthesis and incorporation of myelin polypeptides into CNS myelin.

1982 • 422 citations

Trembler mouse carries a point mutation in a myelin gene

1992 • 418 citations

Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin

1996 • 412 citations

Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13)

1992 • 398 citations

Expression of recombinant plasmids in mammalian cells Is enhanced by sodium butyrate

1983 • 380 citations

Clinical Phenotypes of Different MPZ (P0) Mutations May Include Charcot–Marie–Tooth Type 1B, Dejerine–Sottas, and Congenital Hypomyelination

1996 • 362 citations

Role of myelin Po protein as a homophilic adhesion molecule

1990 • 344 citations

Protein zero (P0)–deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies

1995 • 314 citations

A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse.

1992 • 286 citations

Protein zero of peripheral nerve myelin: Biosynthesis, membrane insertion, and evidence for homotypic interaction

1990 • 276 citations

A growth arrest-specific (gas) gene codes for a membrane protein.

1990 • 252 citations

A myelin protein is encoded by the homologue of a growth arrest-specific gene.

1991 • 217 citations

Axon-regulated expression of a Schwann cell transcript that is homologous to a ‘growth arrest-specific’ gene.

1991 • 182 citations

Biology and Genetics of Hereditary Motor and Sensory Neuropathies

1995 • 179 citations

Charcot-Marie-tooth disease: a new paradigm for the mechanism of inherited disease

1994 • 162 citations

Heterozygous Peripheral Myelin Protein 22-Deficient Mice Are Affected by a Progressive Demyelinating Tomaculous Neuropathy

1997 • 159 citations

The Active Transport of Myelin Basic Protein into the Nucleus Suggests a Regulatory Role in Myelination

1997 • 135 citations

Recombinant peripheral myelin protein P_o confers both adhesion and neurite outgrowth‐promoting properties

1990 • 133 citations

The peripheral myelin glycoprotein P0 expresses the L2/HNK-1 and L3 carbohydrate structures shared by neural adhesion molecules

1987 • 115 citations

Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22.

1998 • 114 citations

Rapid Communication: Human Peripheral Myelin Protein‐22 Carries the L2/HNK‐1 Carbohydrate Adhesion Epitope

1993 • 110 citations

Charcot-Marie-Tooth disease and related peripheral neuropathies.

1997 • 106 citations

Overloaded Endoplasmic Reticulum–Golgi Compartments, a Possible Pathomechanism of Peripheral Neuropathies Caused by Mutations of the Peripheral Myelin Protein PMP22

1998 • 104 citations

L2/HNK‐1 carbohydrate and protein‐protein interactions mediate the homophilic binding of the neural adhesion molecule P0

1992 • 98 citations

The role of complex carbohydrates in adhesion of the myelin protein, P0

1991 • 83 citations

Dominant-negative effect on adhesion by myelin Po protein truncated in its cytoplasmic domain.

1996 • 83 citations

The cytoplasmic domain of myelin glycoprotein P0 interacts with negatively charged phospholipid bilayers.

1994 • 81 citations

The cytoplasmic domain of the myelin P0 protein influences the adhesive interactions of its extracellular domain.

1994 • 77 citations

Expression of myelin basic protein isoforms in nonglial cells.

1990 • 75 citations

Animal models for inherited peripheral neuropathies

1997 • 74 citations

Dejerine-Sottas neuropathy in mother and son with same point mutation of PMP22 gene

1997 • 73 citations

Coexpression of PMP22 gene with MBP and P₀ during de novo myelination and nerve repair

1993 • 63 citations

Ultrastructural Distribution of PMP22 in Charcot-Marie-Tooth Disease Type 1A

1996 • 63 citations

Structural analysis and identification of gel‐purified proteins, available in the femtomole range, using a novel computer program for peptide sequence assignment, by matrix‐assisted laser desorption ionization — reflectron time‐of‐fligh — mass spectrometry

1996 • 61 citations

Protein zero, a nervous system adhesion molecule, triggers epithelial reversion in host carcinoma cells.

1995 • 55 citations

Studies on the effects of altered PMP22 expression during myelination in vitro

1997 • 45 citations

Ins and outs of peripheral myelin protein-22: Mapping transmembrane topology and intracellular sorting

1997 • 41 citations

A Growth Arrest-Specific (gas) Gene Codes for a Membrane Protein

1990 • 39 citations

Charcot-Marie-Tooth Disease and Related Peripheral Neuropathies

1998 • 20 citations

Production and Characterization of Monoclonal Antibodies to the Major Peripheral Myelin Glycoprotein P₀

1990 • 12 citations