HLA-B27 and HLA-A2 subtypes: structure, evolution and function

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

ANKYLOSING SPONDYLITIS AND HL-A 27

1973 • 1,801 citations

Origin of major histocompatibility complex polymorphism: The trans-species hypothesis

1987 • 450 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Advances in Inflammation Research.

1980 • 393 citations

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

1986 • 286 citations

Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

1985 • 255 citations

Histocompatibility Testing 1984

1984 • 252 citations

Immunobiology of HLA

1989 • 175 citations

Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor

1988 • 151 citations

The self determinants recognized by human virus-immune T cells can be distinguished from the serologically defined HLA antigens.

1980 • 112 citations

Monoclonal antibody (B27M2) subdividing HLA-B27

1982 • 106 citations

Six variants of HLA-1327 identified by isoelectric focusing

1986 • 96 citations

Gene conversion-like mechanisms may generate polymorphism in human class I genes.

1986 • 92 citations

Advances in Inflammation Research

1985 • 89 citations

HLA-restricted recognition of viral antigens in HLA transgenic mice

1987 • 89 citations

Mutations in the alpha 2 helix of HLA-A2 affect presentation but do not inhibit binding of influenza virus matrix peptide.

1988 • 83 citations

Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition

1982 • 83 citations

Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules.

1987 • 81 citations

Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules

1980 • 80 citations

Definition of four HLA-A2 subtypes by CML typing and biochemical analysis

1983 • 73 citations

Delineation of immunologically and biochemically distinct HLA-A2 antigens.

1982 • 64 citations

Molecular analysis of a functional subtype of HLA-B27. A possible evolutionary pathway for HLA-B27 polymorphism.

1986 • 61 citations

In vitro mutagenesis at a single residue introduces B and T cell epitopes into a class I HLA molecule.

1987 • 57 citations

Identification of several functional subgroups of HLA-B27 by restriction of the activity of antiviral T killer lymphocytes

1984 • 55 citations

Delineation of functional sites in HLA-B27 antigens. Molecular analysis of HLA-B27 variant Wewak I defined by cytolytic T lymphocytes.

1985 • 55 citations

Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. Selective involvement of CD8 in their class I--directed cytotoxicity.

1987 • 54 citations

Molecular analysis of the variant alloantigen HLA-B27d (HLA-B∗2703) identifies a unique single amino acid substitution

1988 • 52 citations

Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3.

1988 • 52 citations

Molecular characterization of serologic recognition sites in the human HLA-A2 molecule.

1988 • 48 citations

Identification of new B27 subtypes (B27C and B27D) prevalent in oriental populations

1986 • 48 citations

Structural analysis of an HLA-B27 functional variant, B27d, detected in American blacks.

1987 • 47 citations

Primary structure of papain-solubilized human histocompatibility antigen HLA-B27

1985 • 47 citations

Structural analysis of an HLA-B27 population variant, B27f. Multiple patterns of amino acid changes within a single polypeptide segment generate polymorphism in HLA-B27.

1987 • 43 citations

DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1

1987 • 43 citations

Epstein-Barr virus-specific cytotoxic T lymphocytes as probes of HLA polymorphism. Heterogeneity of T cell-restricting determinants associated with the serologically defined HLA-A2 antigen.

1983 • 42 citations

Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes.

1986 • 42 citations

Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype.

1985 • 42 citations

Nomenclature for factors of the HLA system, 1987

1988 • 39 citations

Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity

1985 • 35 citations

HLA-B27 antigenicity: antibodies against the chemically synthesized 63-84 peptide from HLA-B27.1 display alloantigenic specificity and discriminate among HLA-B27 subtypes.

1986 • 31 citations

Complexity of T cell receptor recognition sites for defined alloantigens.

1987 • 30 citations

Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T cells

1983 • 30 citations

Analysis of the molecular basis of HLA-A3 recognition by cytotoxic T cells using defined mutants of the HLA-A3 molecule.

1988 • 28 citations

One allogeneic cytolytic T lymphocyte clone distinguishes three different HLA-B27 subtypes: identification of amino acid residues influencing the specificity and avidity of recognition.

1985 • 25 citations

Structural analysis of HLA-A2.4 functional variant KNE. Implications for the mapping of HLA-A2-specific T-cell epitopes

1988 • 25 citations

Recognition of distinct epitopes on the HLA-A2 antigen by cytotoxic T lymphocytes

1986 • 22 citations

Fine specificity of HLA-B27 cellular allorecognition. HLA-B27f is a functional variant distinguishable by cytolytic T cell clones.

1987 • 19 citations

A cytolytic human T lymphocyte clone differentially recognizing HLA-B27 subtypes

1984 • 19 citations

An HLA-A2 population variant with structural polymorphism in the ?3 region

1988 • 19 citations

Cytotoxic T lymphocyte-defined epitope differences between HLA-A2.1 and HLA-A2.2 map to two distinct regions of the molecule.

1988 • 18 citations

Molecular analysis of HLA-A2.4 functional variant KLO: close structural and evolutionary relatedness to the HLA-A2.2 subtype

1988 • 17 citations

Analysis of the functional epitopes on different HLA-A2 molecules

1984 • 17 citations

Conventional alloantisera can recognize the same HLA-B27 polymorphism as detected by cytotoxic T lymphocytes

1987 • 16 citations

New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes

1987 • 14 citations

Differential recognition by human cytotoxic T cell clones of human M1 fibroblasts transfected with an HLA-B7 gene (JY150) suggests the existence of two different HLA-B7 alleles in the cell line JY (HLA-A2,2;B7,7;Cw-,-;DR4,w6).

1988 • 13 citations

Modulation on immunogenicity by HLA‐B27 subtype polymorphism

1988 • 13 citations

New HLA class I molecules

1989 • 11 citations

An oriental HLA-A2 subtype is closely related to a subset of caucasoid HLA-A2 alleles

1989 • 11 citations

Clonal heterogeneity of HLA-B27 cellular allo-recognition. Delineation of immunodominant sites

1988 • 10 citations