Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus

1990 • 979 citations

TIRAP: an adapter molecule in the Toll signaling pathway

2001 • 962 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Functional macrophage cell lines transformed by abelson leukemia virus

1978 • 895 citations

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

1999 • 829 citations

Neutrophils, host defense, and inflammation: a double-edged sword

1994 • 807 citations

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

2000 • 789 citations

The neutrophil as a cellular source of chemokines

2000 • 775 citations

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism.

1985 • 734 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 • 604 citations

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

2001 • 593 citations

Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.

1983 • 559 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

2000 • 470 citations

Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity

1975 • 426 citations

A CD14-independent LPS receptor cluster

2001 • 422 citations

Selective induction of DNA synthesis in T and B lymphocytes

1972 • 411 citations

CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression

2001 • 405 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling

2001 • 388 citations

Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice

2001 • 376 citations

Protective Roles of Mast Cells Against Enterobacterial Infection Are Mediated by Toll-Like Receptor 4

2001 • 373 citations

Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line.

1987 • 369 citations

Microbial Lipopeptides Stimulate Dendritic Cell Maturation Via Toll-Like Receptor 2

2001 • 360 citations

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor forEscherichiaandSalmonellaLipopolysaccharides

2000 • 352 citations

Different Toll-like receptor agonists induce distinct macrophage responses

2001 • 349 citations

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

2000 • 332 citations

The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)

2001 • 281 citations

Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages

2000 • 279 citations

Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses

2000 • 273 citations

Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line

1975 • 259 citations

Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, But Not IL-10

2000 • 246 citations

Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts.

1972 • 232 citations

Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

2001 • 227 citations

OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway

2000 • 214 citations

In Vivo Expression of Proinflammatory Mediators in the Adult Heart after Endotoxin Administration: The Role of Toll‐Like Receptor–4

2001 • 212 citations

IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide.

1994 • 209 citations

Stem cell factor induces mast cell adhesion to fibronectin.

1994 • 205 citations

Toll Meets Bacterial CpG-DNA

2001 • 186 citations

Escherichia coli P fimbriae utilize the Toll‐like receptor 4 pathway for cell activation

2001 • 173 citations

Mast cells in infection and immunity

1997 • 172 citations

Glomerular epithelial, mesangial, and endothelial cell lines from transgenic mice

1988 • 167 citations

Toll‐like receptors: molecular mechanisms of the mammalian immune response

2000 • 155 citations

Toll-Like Receptors Confer Responsiveness to Lipopolysaccharide fromPorphyromonas gingivalisin Human Gingival Fibroblasts

2000 • 153 citations

Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced byEscherichia coliInfection in Mice

2000 • 150 citations

IL-9 and IL-13 Production by Activated Mast Cells Is Strongly Enhanced in the Presence of Lipopolysaccharide: NF-κB Is Decisively Involved in the Expression of IL-9

2001 • 146 citations

Biologic and Biochemical Activities of Continuous Macrophage Cell Lines P388D1 and J774.1

1977 • 143 citations

Involvement of Lipopolysaccharide Binding Protein, CD14, and Toll-Like Receptors in the Initiation of Innate Immune Responses byTreponemaGlycolipids

2000 • 141 citations

Cloning and Characterization of the Murine Toll-like Receptor 5 (Tlr5) Gene: Sequence and mRNA Expression Studies in Salmonella-Susceptible MOLF/Ei Mice

2000 • 135 citations

Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin

1995 • 109 citations

Immortalized dendritic cell line fully competent in antigen presentation initiates primary T cell responses in vivo.

1993 • 108 citations

Toll-Like Receptor 4-Deficient Mice Have Reduced Bone Destruction following Mixed Anaerobic Infection

2000 • 104 citations

Mouse Myelomas producing Precipitating Antibody to Nucleic Acid Bases and/or Nitrophenyl Derivatives

1968 • 102 citations

Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen.

1993 • 101 citations

Priming of neutrophils by lipopolysaccharide for enhanced release of superoxide. Requirement for plasma but not for tumor necrosis factor-alpha.

1990 • 90 citations

Cell cycle related heterogeneity of Ia antigen expression on a murine B lymphoma cell line:analysis by flow cytometry.

1981 • 81 citations

Cutting Edge: Human B Cell Function Is Regulated by Interaction with Soluble CD14: Opposite Effects on IgG1 and IgE Production

2000 • 78 citations

Production of interleukin 3 and gamma-interferon by an antigen-specific mouse suppressor T cell clone.

1985 • 77 citations

Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products.

1986 • 74 citations

Induction of TNF-α and MnSOD by endotoxin: role of membrane CD14 and Toll-like receptor-4

2001 • 57 citations

Non‐IgE‐dependent bacteria‐induced histamine release from human lung and tonsillar mast cells

1987 • 56 citations

Immunologic characteristics in relation to high and low leukemogenic activity of radiation leukemia virus variants. I. Cellular analysis of immunosuppression.

1977 • 52 citations

Modulation of cytokine expression in mouse dendritic cell clones

1994 • 47 citations

Genetic Structure and Chromosomal Mapping of MyD88

1997 • 45 citations

The Role of Cell Surface Receptors in the Activation of Human B Cells by Phosphorothioate Oligonucleotides

2000 • 41 citations

Immunologic characteristics in relation to high and low leukemogenic activity of radiation leukemia virus variants. II. Analysis of the immune response.

1977 • 33 citations

Immortalization of Mouse Bone Marrow-Derived Mast Cells with Ad12-SV40 Virus

1993 • 31 citations

CD14‐Dependent and Independent Pathways in Lipopolysaccharide‐Induced Activation of a Murine B‐Cell Line, CH12.LX

2000 • 24 citations

Differential Expression and Regulation of Macrophage Inflammatory Protein (MIP)-1α and MIP-2 Genes by Alveolar and Peritoneal Macrophages in LPS-Hyporesponsive C3H/HeJ Mice

2000 • 19 citations

Effects of 15-deoxy-Δ12,14 prostaglandin J2 and interluekin-4 in Toll-like receptor-4-mutant glial cells

2001 • 11 citations

Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1β

2002 • 10 citations