The Effects of Hill-Robertson Interference Between Weakly Selected Mutations on Patterns of Molecular Evolution and Variation

Numerical recipes in C: the art of scientific computing

1993 • 18,639 citations

The genetical theory of natural selection

1930 • 17,330 citations

Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

1989 • 13,216 citations

Numerical recipes in Pascal: the art of scientific computing

1990 • 12,293 citations

EVOLUTION IN MENDELIAN POPULATIONS

1931 • 8,698 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

On the number of segregating sites in genetical models without recombination

1975 • 3,989 citations

Statistical tests of neutrality of mutations.

1993 • 3,901 citations

The hitch-hiking effect of a favourable gene

1974 • 3,276 citations

The Evolution of Sex

1978 • 3,074 citations

The hitch-hiking effect of a favourable gene

2007 • 2,840 citations

The relation of recombination to mutational advance

1964 • 2,547 citations

Selection and Covariance

1970 • 1,938 citations

The effect of deleterious mutations on neutral molecular variation.

1993 • 1,838 citations

The effect of linkage on limits to artificial selection

1966 • 1,822 citations

How clonal are bacteria?

1993 • 1,804 citations

Mathematical Population Genetics

2006 • 1,764 citations

THE EVOLUTIONARY ADVANTAGE OF RECOMBINATION

1974 • 1,737 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

The effect of linkage on limits to artificial selection

2007 • 1,640 citations

Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes

1986 • 1,148 citations

The selection-mutation-drift theory of synonymous codon usage.

1991 • 994 citations

Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster

1992 • 987 citations

Accelerated evolution and Muller's rachet in endosymbiotic bacteria.

1996 • 983 citations

An evolutionary perspective on synonymous codon usage in unicellular organisms

1986 • 874 citations

Expression pattern and, surprisingly, gene length shape codon usage inCaenorhabditis,Drosophila, andArabidopsis

1999 • 782 citations

Mathematical Population Genetics.

1980 • 756 citations

Population genetics of polymorphism and divergence.

1992 • 637 citations

The hitchhiking effect on the site frequency spectrum of DNA polymorphisms.

1995 • 620 citations

"Silent" sites in Drosophila genes are not neutral: evidence of selection among synonymous codons.

1988 • 535 citations

The evolution of chromosomal sex determination and dosage compensation

1996 • 535 citations

THE MUTATIONAL LOAD WITH EPISTATIC GENE INTERACTIONS IN FITNESS

1966 • 523 citations

The accumulation of deleterious genes in a population—Muller's Ratchet

1978 • 490 citations

The pattern of neutral molecular variation under the background selection model.

1995 • 431 citations

Evolution of the Y Sex Chromosome in Animals

1996 • 426 citations

Intraspecific nuclear DNA variation in Drosophila

1996 • 425 citations

Linkage and the limits to natural selection.

1995 • 397 citations

The effect of background selection against deleterious mutations on weakly selected, linked variants

1994 • 376 citations

Inbreeding in artificial selection programmes

1961 • 349 citations

Ancestral Processes with Selection

1997 • 336 citations

The Genealogy of Samples in Models With Selection

1997 • 319 citations

Inbreeding in artificial selection programmes

2007 • 316 citations

Evolution of codon usage bias in Drosophila

1997 • 311 citations

Codon usage inCaenorhabditis elegans: delineation of translational selection and mutational biases

1994 • 289 citations

Effects of linkage on rates of molecular evolution.

1988 • 286 citations

The Evolution of Recombination: Removing the Limits to Natural Selection

1997 • 277 citations

Natural Selection on Synonymous Sites Is Correlated With Gene Length and Recombination in Drosophila

1999 • 272 citations

Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons

1987 • 271 citations

Selection intensity for codon bias.

1994 • 269 citations

Reduced natural selection associated with low recombination in Drosophila melanogaster.

1993 • 263 citations

Contamination of the genome by very slightly deleterious mutations: why have we not died 100 times over?

1995 • 243 citations

Gene length and codon usage bias in Drosophila melanogaster, Saccharomyces cerevisiae and Escherichia coli

1998 • 224 citations

Unraveling selection in the mitochondrial genome of Drosophila.

1994 • 221 citations

Theoretical foundation of population genetics at the molecular level

1971 • 198 citations

Codon usage and gene function are related in sequences of Arabidopsis thaliana

1998 • 180 citations

Natural Selection and the Frequency Distributions of “Silent” DNA Polymorphism in Drosophila

1997 • 179 citations

Mutation accumulation in nuclear, organelle, and prokaryotic transfer RNA genes

1997 • 175 citations

Inferring the Fitness Effects of DNA Mutations From Polymorphism and Divergence Data: Statistical Power to Detect Directional Selection Under Stationarity and Free Recombination

1999 • 171 citations

Effective size of populations under selection.

1995 • 169 citations

A population genetic model for the evolution of synonymous codon usage: patterns and predictions

1999 • 155 citations

Deleterious mutations in animal mitochondrial DNA

1998 • 138 citations

Untitled

1998 • 126 citations

Effective Size and Polymorphism of Linked Neutral Loci in Populations Under Directional Selection

1998 • 101 citations

Untitled

1998 • 95 citations

Rates of DNA sequence evolution are not sex-biased in Drosophila melanogaster and D. simulans

1997 • 94 citations

Gene Trees with Background Selection

1994 • 94 citations

Synonymous substitution rates in enterobacteria.

1995 • 78 citations

Genealogies and weak purifying selection

1999 • 73 citations

The Effect of Purifying Selection on Genealogies

1997 • 36 citations

The effect of background selection at a single locus on weakly selected, partially linked variants

1999 • 36 citations

The evolution of the mammalian Y chromosome

1990 • 12 citations