Human Anti-Animal Antibody Interferences in Immunological Assays

The uses and properties of PEG-linked proteins.

1992 • 425 citations

MEDICAL NEMESIS

1974 • 377 citations

Heterophilic antibodies: a problem for all immunoassays.

1988 • 306 citations

In vivo effects of murine hybridoma monoclonal antibody in a patient with T-cell leukemia

1981 • 260 citations

Use of porcine factor VIII in the treatment of patients with acquired hemophilia

1993 • 253 citations

Immunogenicity and Allergenic Potential of Animal and Human Insulins

1993 • 244 citations

Incidence and specificity of interference in two-site immunoassays.

1986 • 214 citations

Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody.

1991 • 204 citations

Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3.

1986 • 186 citations

Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies?

1994 • 178 citations

Serotherapy of B-cell neoplasms with anti-B4-blocked ricin: a phase I trial of daily bolus infusion

1992 • 174 citations

False Increase of Cardiac Troponin I with Heterophilic Antibodies

1998 • 168 citations

SPECIFICITY OF THE DIRECT SOLID-PHASE RADIOIMMUNOASSAY FOR DETECTION OF HEPATITIS-B ANTIGEN

1973 • 154 citations

The use of monoclonal antibodies and antibody fragments in the imaging of infectious lesions

1994 • 150 citations

ANTI-BOVINE SERUM ALBUMIN AND ANTI-ALPHA LACTALBUMIN IN THE SERUM OF CHILDREN AND ADULTS

1965 • 150 citations

Radioimmunotherapy: recent results and future directions.

1996 • 139 citations

Antibodies as cytotoxic therapy.

1994 • 127 citations

Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group.

1996 • 127 citations

Circulating antibodies to mouse monoclonal immunoglobulins in normal subjects--incidence, species specificity, and effects on a two-site assay for creatine kinase-MB isoenzyme.

1986 • 124 citations

Phase I trial of murine monoclonal antibody 14G2a administered by prolonged intravenous infusion in patients with neuroectodermal tumors.

1994 • 117 citations

Pilot trial of murine monoclonal antibodies in patients with advanced melanoma.

1985 • 112 citations

Immunogenicity and Reactogenicity of Influenza Subunit Vaccines Produced in MDCK Cells or Fertilized Chicken Eggs

1997 • 109 citations

"Sandwich"-type immunoassay of carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and therapy.

1988 • 106 citations

Interference by human anti-mouse antibody in two-site immunoassays

1990 • 103 citations

Development of human anti‐murine antibody (HAMA) response in patients

1990 • 102 citations

A phase I toxicity, pharmacology, and dosimetry trial of monoclonal antibody OKB7 in patients with non-Hodgkin's lymphoma: effects of tumor burden and antigen expression.

1990 • 92 citations

Safety Profile of Porcine Factor VIII and Its Use as Hospital and Home-Therapy for Patients with Haemophilia-A and Inhibitors: the Results of An International Survey

1996 • 89 citations

Multiple infusions of anti-epidermal growth factor receptor (EGFR) monoclonal antibody (EMD 55 900) in patients with recurrent malignant gliomas

1996 • 84 citations

Polyethylene Glycol Modification: Relevance of Improved Methodology to Tumour Targeting

1996 • 81 citations

Repeated antitumour antibody therapy in man with suppression of the host response by cyclosporin A

1988 • 81 citations

Antibody multispecificity in immunoassay interference

1992 • 80 citations

Generation, Characterization, andin VivoStudies of Humanized Anticarcinoma Antibody CC49

1995 • 77 citations

Circulating antibodies to cow's milk proteins in ulcerative colitis

1972 • 76 citations

Circulating Antibodies to Bovine Albumin in Ulcerative Colitis and Crohn's Disease

1976 • 76 citations

Activating anti-idiotypic human anti-mouse antibodies for immunotherapy of ovarian carcinoma

1994 • 75 citations

Immunoscintigraphy of inflammatory processes with a technetium-99m-labeled monoclonal antigranulocyte antibody (MAb BW 250/183).

1990 • 75 citations

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

1992 • 73 citations

Intranasal Salcatonin (Salmon Calcitonin)

1996 • 64 citations

Heterophilic antibodies in human sera causing falsely increased results in the CA 125 immunofluorometric assay

1990 • 63 citations

Chicken Antibodies: A Tool to Avoid Interference by Human Anti-Mouse Antibodies in ELISA After In Vivo Treatment With Murine Monoclonal Antibodies

1992 • 62 citations

Enhanced tumour specificity of an anti-carcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification

1996 • 62 citations

Heterophilic Antibodies Interfering With Radioimmunoassay

1982 • 62 citations

Heterologous double-determinant immunoradiometric assay CA 125 II: reliable second-generation immunoassay for determining CA 125 in serum

1993 • 61 citations

Transient Neonatal Hyperthyrotropinemia: A Factitious Syndrome due to the Presence of Heterophilic Antibodies in the Plasma of Infants and Their Mothers

1981 • 60 citations

Immunopharmacology

1997 • 59 citations

Eliminating interference from heterophilic antibodies in a two-site immunoassay for creatine kinase MB by using F(ab')2 conjugate and polyclonal mouse IgG.

1992 • 59 citations

Immunity in malaria

1934 • 59 citations

Interference by anti-immunoglobulin G antibodies in immunoradiometric assays of thyrotropin involving mouse monoclonal antibodies.

1987 • 58 citations

Anti-carcinoembryonic antigen immunoscintigraphy (technetium-99m-monoclonal antibody BW 431/26) and serum CEA levels in patients with suspected primary and recurrent colorectal carcinoma.

1991 • 58 citations

Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.

1996 • 56 citations

A simple qualitative determination of human antibodies to murine immunoglobulins (HAMA) in serum samples

1989 • 55 citations

Zum Thema: Hepatitis und Bluttransfusion¹

1955 • 54 citations

Phase I study of a murine monoclonal anti-lipid A antibody in bacteremic and nonbacteremic patients

1988 • 54 citations

Eliminating Interference from Heterophilic Antibodies in a Two-Site Immunoassay for Creatine Kinase Mb by Using F(ab')2 Conjugate and Polyclonal Mouse IgG

1992 • 54 citations

Human anti-mouse antibody response to the injection of murine monoclonal antibodies against IL-6

1994 • 51 citations

The OKT3 antibody response study: a multicentre study of human anti-mouse antibody (HAMA) production following OKT3 use in solid organ tranplantation

1995 • 49 citations

The Potential of Catalytic Antibodies.

1996 • 49 citations

Antibodies as a source of analytical errors.

1990 • 47 citations

Multiple spuriously abnormal thyroid function indices due to heterophilic antibodies

1994 • 47 citations

Humanized anti-Lewis Y antibodies: in vitro properties and pharmacokinetics in rhesus monkeys.

1996 • 46 citations

Human immunological response to mouse monoclonal antibodies in the treatment or diagnosis of malignant diseases

1988 • 46 citations

Reducing interference from heterophilic antibodies in a two-site immunoassay for carcinoembryonic antigen (CEA) by using a human/mouse chimeric antibody to CEA as the tracer

1995 • 44 citations

Current status of cancer immunodetection with radiolabeled human monoclonal antibodies

1993 • 43 citations

Persistent Problems with the Specificity of Immunometric TSH Assays

1993 • 41 citations

False Hyperthyrotropinemia Induced by Heterophilic Antibodies against Rabbit Serum

1981 • 39 citations

The clinical significance of HAMA in patients treated with mouse monoclonal antibodies

1992 • 39 citations

Falsely Elevated Steroidal Assay Levels Related to Heterophile Antibodies against Various Animal Species

1995 • 38 citations

Prevention of acute GVHD by in vivo use of anti-interleukin-2 receptor monoclonal antibody (33B3.1): a feasibility trial in 15 patients.

1991 • 37 citations

Impact of radiolabeled antibody imaging on management of colon cancer

1989 • 37 citations

Active specific immunotherapy of metastatic melanoma with an antiidiotype vaccine: a phase I/II trial of I-Mel-2 plus SAF-m.

1997 • 37 citations

Radioimaging of melanoma using 99mTc-labeled Fab fragment reactive with a high molecular weight melanoma antigen.

1990 • 36 citations

Artifactual CEA Elevation due to Human Anti-Mouse Antibodies

1988 • 35 citations

Heterophilic Serum Antibodies: A Cause for Falsely Elevated Serum Thyrotropin Levels

1987 • 35 citations

Evidence for interaction of human anti-idiotypic antibodies with CA 125 determination in a patient after radioimmunodetection

1990 • 34 citations

Human/mouse chimeric antibodies show low reactivity with human anti-murine antibodies (HAMA)

1992 • 34 citations

Interference by human anti-mouse antibodies in CA 125 assay after immunoscintigraphy: anti-idiotypic antibodies not neutralized by mouse IgG but removed by chromatography

1990 • 33 citations

Clinical evaluation of tumor targeting with the anticarcinoembryonic antigen murine monoclonal antibody fragment, MN-14 F(ab)2

1996 • 31 citations

Escape from blockade of interfering heterophile antibodies in a two-site immunoradiometric assay for thyrotropin.

1988 • 31 citations

ANTI-CD45 MONOCLONAL ANTIBODY PERFUSION OF HUMAN RENAL ALLOGRAFTS PRIOR TO TRANSPLANTATION A SAFETY AND IMMUNOHISTOLOGICAL STUDY

1995 • 31 citations

Minor human antibody response to a mouse and chimeric monoclonal antibody after a single i.v. infusion in ovarian carcinoma patients: a comparison of five assays

1995 • 29 citations

Human anti‐mouse antibody suppression with cyclosporin A

1994 • 29 citations

Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas

1990 • 28 citations

THE INCIDENCE OF ANTIBODY FORMATION TO OKT3 CONSEQUENT TO ITS USE IN ORGAN TRANSPLANTATION

1995 • 28 citations

Heterophilic Antibodies Produce Spuriously Elevated Concentrations of the MB Isoenzyme of Creatine Kinase in a Selected Patient Population

1997 • 27 citations

Antiidiotypic response against murine monoclonal antibodies reactive with tumor-associated antigen TAG-72.

1997 • 25 citations

The potency of immunoglobulin G fragments for inhibition of interference caused by anti-immunoglobulin antibodies in a monoclonal immunoradiometric assay for thyrotropin.

1988 • 25 citations

False-positive human chorionic gonadotropin levels caused by a heterophile antibody with the immunoradiometric assay

1988 • 25 citations

Heterophile Antibodies to Rabbit Erythrocytes in Human Sera and Identification of the Antigen as a Glycolipid

1984 • 24 citations

Heterophilic Antibodies Against Rabbit Serum Causing Falsely Elevated Gonadotropin Levels

1989 • 24 citations

Phase I clinical and pharmacological study of suppression of human antimouse antibody response to monoclonal antibody L6 by deoxyspergualin.

1995 • 24 citations

Human anti-mouse antibody suppression with cyclosporin A

1994 • 23 citations

Interference in a two-site immunoradiometric assay for thyrotropin in a child.

1985 • 23 citations

Measures to overcome HAMA interferences in immunoassays.

1997 • 23 citations

PREVENTION OF ADVERSE CLINICAL OUTCOME BY MONITORING OF CARDIAC TRANSPLANT PATIENTS FOR MURINE MONOCLONAL CD3 ANTIBODY (OKT3) SENSITIZATION

1993 • 23 citations

Phase I clinical trial of drug-monoclonal antibody conjugates in patients with advanced colorectal carcinoma: a preliminary report.

1989 • 22 citations

Human Heterophile Antibodies Recognizing Epitopes Present on Insect Glycolipids1

1991 • 21 citations

Anti-Antiserum Antibody as a Cause of Double Precipitin Rings in Immunoglobulin Quantitation and Its Relation to Milk Precipitins

1971 • 21 citations

Anticipating, recognizing, and preventing hazards associated with in vivo use of monoclonal antibodies: special considerations related to human anti-mouse antibodies.

1990 • 21 citations

Murine monoclonal antibody adsorbed onto vinylidene fluoride floccules used to eliminate antibody interference in "sandwich"-type immunoassays.

1989 • 21 citations

Population Study of Heterophile Antibodies

1980 • 21 citations

The use of antibodies in clinical cardiology

1992 • 20 citations

POLYMERIC IgA ANTIBODY RESPONSE TO RABBIT ANTITHYMOCYTE GLOBULIN IN RENAL TRANSPLANT RECIPIENTS

1988 • 20 citations

Monitoring cancer antigen 125 in serum of ovarian cancer patients after administration of 131I-labeled F(ab')2 fragments of OC125 antibody.

1993 • 20 citations

Artefactual increase in serum thyrotropin concentration caused by heterophilic antibodies with specificity for IgG of the family Bovidea.

1986 • 20 citations

Value of HAMA--determination in clinical practice--an overview.

1997 • 19 citations

99mTc-Anti-CEA Radioimmunoscintigraphy of Lung Adenocarcinoma

1991 • 19 citations

Anti-B cell antibodies for the treatment of monoclonal Epstein-Barr virus-induced lymphoproliferative syndrome after multivisceral transplantation.

1994 • 19 citations

An assay for the detection of human anti-murine immunoglubulins in the presence of CA125 antigen

1988 • 18 citations

Monitoring cancer antigen 125 in serum of ovarian cancer patients after administration of 131I-labeled F(ab')2 fragments of OC125 antibody

1993 • 18 citations

Pseudohypergonadotropinemia and pseudohyperprolactinemia induced by heterophilic antibodies?

1984 • 18 citations

Hypergonadotropinemia not associated to ovarian failure and induced by factors interfering in radioimmunoassay

1991 • 17 citations

Use of technetium antigranulocyte monoclonal antibody Fab' fragments for the detection of osteomyelitis

1994 • 17 citations

Incidence of autoantibodies to GPIIb/IIIa in chronic autoimmune thrombocytopenic purpura may be overestimated by the MAIPA

1994 • 16 citations

Immunoglobulin Ihhibiting Reagent®: Evaluation of a New Method for Eliminating Spurious Elevations in CA125 Caused by HAMA

1996 • 16 citations

CA 125 determined by three methods in samples from patients with human anti-mouse antibodies (HAMA)

1995 • 15 citations

Use of rabbit anti-thymocyte globulin for induction immunosuppression in high-risk kidney transplant recipients

1997 • 15 citations

Studies on heterophile antibodies in rheumatoid arthritis

1978 • 15 citations

Colorectal carcinoma metastases: detection with In-111-labeled monoclonal antibody CCR 086.

1990 • 15 citations

Antibody Interference in a Two-Site Immunometnc Assay for Thyrotrophin

1989 • 15 citations

Interference by Human Antibodies with Tumor Marker Assays

1995 • 15 citations

Activity concentration and mass concentration (monoclonal antibody immunoenzymometric method) compared for creatine kinase MB isoenzyme in serum.

1986 • 15 citations

Studies of pancreatic cancer utilizing monoclonal antibodies

1990 • 14 citations

Invalidity from nonparallelism in a radioimmunoassay for erythropoietin accounted for by human serum antibodies to rabbit IgG.

1993 • 14 citations

Interference in immunoenzymometric assays caused by IgM anti-mouse IgG antibodies.

1988 • 14 citations

Prognostic factors for radioimmunotherapy in patients with B-lymphocytic malignancies.

1995 • 14 citations

Reactivity of an anti-(human gastric carcinoma) monoclonal antibody with core-related peptides of gastrointestinal mucin

1991 • 14 citations

Artefactual increase in serum thyrotropin concentration caused by heterophilic antibodies with specificity for IgG of the family Bovidea.

1986 • 14 citations

Interlaboratory Survey of Methods for Measuring Human Anti-Mouse Antibodies

1992 • 13 citations

Analytical and clinical performance of improved Abbott IMx CA 125 assay: comparison with Abbott CA 125 RIA

1995 • 13 citations

Specific and nonspecific immunoassays to detect HAMA after administration of indium-111-labeled OV-TL 3 F(ab')2 monoclonal antibody to patients with ovarian cancer.

1992 • 13 citations

PLACENTAL TRANSFER OF MATERNAL ANTI‐RABBIT IgG CAUSING FALSELY ELEVATED TSH LEVELS IN NEONATES

1981 • 13 citations

Survey of methods for measuring human anti-mouse antibodies

1993 • 13 citations

Sensitization to OKT3 monoclonal antibody in heart transplantation: correlation with early allograft loss.

1991 • 12 citations

Clinical Applications of Monoclonal Antibody Technology

1986 • 12 citations

Clinical validation of an antibody-capture anti-rubella IgM-ELISA

1985 • 12 citations

Analytical and clinical performance of improved Abbott IMx CA 125 assay: comparison with Abbott CA 125 RIA.

1995 • 12 citations

A Case of Graves' Disease with False Hyperthyrotropinemia Who Developed Silent Thyroiditis.

1991 • 11 citations

IgG subclass distributions of anti-horse serum antibodies and natural venom-antibodies produced in response to antivenom injection or snake bite in humans

1990 • 11 citations

Immuntherapie des fortgeschrittenen Pankreaskarzinoms mit dem monoklonalen Antikörper BW 494

2008 • 11 citations

Preexisting Human Anti-murine Antibodies and the Effect of Immune Complexes on the Outcome of Immunoscintigraphy

1993 • 9 citations

Biodistribution of Murine and Chimeric Fab Fragments of the Monoclonal Antibody A7 in Human Pancreatic Cancer

1995 • 9 citations

Potential for Artifacts in Monitoring for the Detection of Tumor Associated Antigens (TAG-72 and CEA) in Serum from Patients Undergoing MAb-based Diagnostic and Therapeutic Protocols

1990 • 8 citations

Falsely Low Results in CA 125 Determination Due to Anti-Idiotypic Antibodies Induced by Infusion of [131I]F(ab′)2 Fragments of the OC125 Antibody

1993 • 8 citations

Diagnostic Applications and Therapeutic Approaches with Different Preparations of Anti-CEA Antibodies

1992 • 8 citations

Monoclonal antibodies in human organ transplantation and auto-immune diseases.

1992 • 6 citations

Circulating antibodies to mouse monoclonal immunoglobulins caused false-positive results in a two-site assay for alpha-fetoprotein.

1989 • 6 citations

The detection of rubella-specific IgM by an immunosorbent assay with solid-phase attachment of red cells (SPARC)

1982 • 6 citations

[Erroneous prolactin determination caused by heterophile antibodies].

1995 • 5 citations

Population Study of Heterophile Antibodies

1980 • 5 citations

Circulating antibodies to monoclonal immunoglobulins used in a follitropin assay may cause incorrect fertility diagnosis.

1989 • 5 citations

Immunological study of heart diseases with special reference to the cytotoxicity of the heterophile antibody against cultured myocardial cells.

1984 • 5 citations

Anaphylaktischer Schock nach wiederholter Injektion von 99mTc-markiertem CEA-Antikörper

1994 • 4 citations

Suppression of antibody responses in rats to murine anti-CD4 monoclonal antibodies by conjugates with monomethoxypolyethylene glycol

1992 • 4 citations

[Factors that affect analytical results in an enzyme immunoassay].

1995 • 4 citations

Potential artifact for the increase of tumor associated antigens in serum samples from patients injected with monoclonal antibodies

1991 • 4 citations

Heterophile antibody to red cells in human trypanosomiasis.

1978 • 3 citations

SPECIFICITY OF TRANSPLANTATION HETEROPHILE ANTIBODIES

1984 • 3 citations

Clinical Comparison of Immunoradiometric Assays for Intact Versus Beta-Specific Human Chorionic Gonadotropin

1990 • 3 citations

A Simple and Sensitive Assay for Determination of Human Anti-Idiotypic Anti-B72.3 Antibodies, which Is not Affected by the Presence of Tumour-Associated Glycoprotein 72

1996 • 3 citations

Antibodies to equine antithymocyte globulin in heart transplant recipients: evaluation of an enzyme immunoassay.

1984 • 3 citations

Clinical uses of anti-thymocyte globulin (ATGAM), Part I.

1984 • 3 citations

Serum levels of tumor markers and presence of human antimouse antibodies: implications for diagnosis and treatment with radiolabeled monoclonal antibodies.

1988 • 3 citations

Comparative biodistribution and antibody-dependent cellular cytotoxicity of native and heavy chain chimeric antibody.

1991 • 3 citations

[Production of human antimurine antibody after in vivo use of radioisotope labelled murine antibodies].

1991 • 3 citations

Heterophile Antibodies in the Serum of Children with Nephrotic Syndrome

1980 • 2 citations

[Thyroid diagnosis: false TSH determination caused by heterophilic antibodies].

1991 • 2 citations

Heterophile Antibodies in the Serum of Children with Nephrotic Syndrome

1980 • 2 citations

Cases of Graves' Disease with Falsely High TSH Values due to Interfering Substances which Cross-link with Mouse Monoclonal Antibodies in the TSH Assay Kits

1993 • 2 citations

Profiles of heterophile antibody to various mammalian erythrocytes in rural populations of Zambia

1987 • 2 citations

Thrombosediagnostik mit einem murinen Anti-Thrombozyten- Antikörper (99mTc-BW 4): Erste klinische Erfahrungen

1993 • 1 citations

Immunity in malaria: II. Heterophile and malarial antibodies in acute Plasmodium falciparum infection.

1989 • 1 citations