Generation, Characterization, andin VivoStudies of Humanized Anticarcinoma Antibody CC49

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Conformations of immunoglobulin hypervariable regions

1989 • 1,165 citations

Anatomy of the antibody molecule

1994 • 868 citations

REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

1988 • 703 citations

A humanized antibody that binds to the interleukin 2 receptor.

1989 • 624 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

A spectrum of monoclonal antibodies reactive with human mammary tumor cells.

1981 • 565 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

Antibody framework residues affecting the conformation of the hypervariable loops

1992 • 507 citations

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.

1989 • 456 citations

Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3.

1986 • 408 citations

Human colonic adenocarcinoma cells

1976 • 375 citations

Reshaping Human Antibodies: Grafting an Antilysozyme Activity

1988 • 348 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

1991 • 342 citations

In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

1990 • 304 citations

Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

1990 • 238 citations

Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen.

1988 • 210 citations

Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody.

1983 • 208 citations

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex

1992 • 201 citations

Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution

1991 • 175 citations

A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

1991 • 168 citations

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

1991 • 162 citations

Pharmacokinetics and immune response of 131I-chimeric mouse/human B72.3 (human gamma 4) monoclonal antibody in humans.

1991 • 118 citations

Humanized antibodies for therapy

1991 • 110 citations

Reduced immunogenicity and improved pharmacokinetics of humanized anti-Tac in cynomolgus monkeys.

1991 • 106 citations

Expression in COS cells of a mouse—human chimaeric B72.3 antibody

1987 • 100 citations

Enhanced tumor binding using immunohistochemical analyses by second generation anti-tumor-associated glycoprotein 72 monoclonal antibodies versus monoclonal antibody B72.3 in human tissue.

1990 • 100 citations

Reshaping a therapeutic CD4 antibody.

1991 • 95 citations

Pharmacokinetics, immune response, and biodistribution of iodine-131-labeled chimeric mouse/human IgG1,k 17-1A monoclonal antibody.

1991 • 82 citations

Secretion of a single-gene-encoded immunoglobulin from myeloma cells.

1993 • 63 citations

Polymerase chain reaction facilitates the cloning, CDRgrafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte integrins

1991 • 59 citations

Differential metabolic patterns of iodinated versus radiometal chelated anticarcinoma single-chain Fv molecules.

1992 • 58 citations

Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions

1994 • 47 citations

A phase II trial of murine monoclonal antibody 17-1A and interferon-γ: Clinical and immunological data

1990 • 46 citations

Optimal humanization of 1B4, an anti-CD18 murine monoclonal antibody, is achieved by correct choice of human V-region framework sequences.

1993 • 45 citations

Construction of reshaped human antibodies with HIV-neutralizing activity

1991 • 45 citations

Biologic properties of a C_h2 domain‐deleted recombinant immunoglobulin

1993 • 44 citations

Comparative biological properties of a recombinant chimeric anti-carcinoma mAb and a recombinant aglycosylated variant

1992 • 31 citations

Biochemical Characterization of a Monoclonal Antibody to the H Type-2 Antigen: Comparison to Other ABH Antibodies

1986 • 24 citations

Crystallographic studies and primary structure of the antitumor monoclonal CC49 Fab′

1993 • 5 citations