Adenovirus E1A Coding Sequences That Enable ras and pmt Oncogenes To Transform Cultured Primary Cells

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

1981 • 435 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

1983 • 373 citations

The roles of individual polyoma virus early proteins in oncogenic transformation

1982 • 366 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Common Control of the Heat Shock Gene and Early Adenovirus Genes: Evidence for a Cellular E1A-like Activity

1984 • 331 citations

Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication

1984 • 292 citations

Regulation of heat shock protein 70 gene expression by c-myc

1984 • 270 citations

cis and trans activation of globin gene transcription in transient assays.

1983 • 257 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.

1983 • 240 citations

Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

1981 • 237 citations

Defective transforming capacity of adenovirus type 5 host-range mutants

1978 • 211 citations

Isolation and characterization of the mouse metallothionein-I gene.

1980 • 210 citations

Control of adenovirus early gene expression: A class of immediate early products

1980 • 182 citations

Cis-acting induction of adenovirus transcription

1983 • 180 citations

E1A Control of Gene Expression Is Mediated by Sequences 5′ to the Transcriptional Starts of the Early Viral Genes

1983 • 169 citations

The x Gene Is Essential for HTLV Replication

1985 • 161 citations

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

1984 • 153 citations

Adenovirus 2 early region 1A stimulates expression of both viral and cellular genes.

1984 • 150 citations

Dissection of overlapping functions within the adenovirus type 5 E1A gene.

1984 • 146 citations

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

1984 • 138 citations

Proteins and messenger RNAs of the transforming region of wild-type and mutant adenoviruses

1980 • 132 citations

Transcriptional Activation and Subsequent Control of the Human Heat Shock Gene During Adenovirus Infection

1983 • 131 citations

Transformation-defective mutant of adenovirus type 5 containing a single altered E1a mRNA species

1981 • 123 citations

trans Activation of the Simian Virus 40 Late Transcription Unit by T-Antigen

1985 • 118 citations

An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cells

1985 • 112 citations

Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: Genetic evidence of an adenovirus transformation maintenance function

1982 • 103 citations

Transformation-deficient adenovirus mutant defective in expression of region 1A but not region 1B

1982 • 78 citations

An adenovirus mutant defective in splicing RNA from early region 1A

1981 • 78 citations

Cancer cells 2: Oncogenes and viral genes

1985 • 76 citations

Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing

1984 • 69 citations

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.

1985 • 57 citations

The molecular structure of the 9 S mRNA from early region 1A of adenovirus serotype 2

1983 • 52 citations

Cold-sensitive expression of transformation by a host range mutant of type 5 adenovirus.

1983 • 46 citations

Differential response of multiple ϵ-globin cap sites to cis- and trans-acting controls

1984 • 45 citations

Adenovirus 5 E2 Transcription Unit: an E1A-Inducible Promoter with an Essential Element That Functions Independently of Position or Orientation

1984 • 40 citations

Control Functions of Adenovirus Transformation Region E1A Gene Products in Rat and Human Cells

1985 • 20 citations

Selective Inhibition of Adenovirus Type 2 Early Region II and III Transcription by an Anisomycin Block of Protein Synthesis

1982 • 11 citations

Accelerated Onset of Viral Transcription in Adenovirus-Infected HeLa Cells Treated with the Tumor Promoter 12-O-Tetradecanoyl-Phorbol-13-Acetate

1984 • 3 citations