Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Principles of protein-protein interactions.

1996 • 2,594 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

1989 • 664 citations

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

1991 • 663 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

1997 • 444 citations

Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

1989 • 411 citations

N.m.r. and molecular-modelling studies of the solution conformation of heparin

1993 • 400 citations

Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

1993 • 379 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

1998 • 350 citations

Rapid Selection Using G418 of High Copy Number Transformants of Pichia pastoris for High–level Foreign Gene Expression

1994 • 308 citations

Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

1992 • 297 citations

Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis

1996 • 277 citations

Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury.

1993 • 253 citations

Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript

1991 • 224 citations

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

1992 • 222 citations

Renotropic functions of hepatocyte growth factor in renal regeneration after unilateral nephrectomy.

1991 • 204 citations

Halloween ... Masks and Bones

1994 • 202 citations

Molecular evolution and domain structure of plasminogen‐related growth factors (HGF/SF and HGF1/MSP)

1994 • 175 citations

Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.

1996 • 143 citations

Hepatocyte Growth Factor (HGF)/NK1 Is a Naturally Occurring HGF/Scatter Factor Variant with Partial Agonist/Antagonist Activity

1996 • 137 citations

An alternatively processed mRNA generated from human hepatocyte growth factor gene

1991 • 111 citations

Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor.

1994 • 107 citations

Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-.ANG. resolution

1991 • 103 citations

Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo

1998 • 97 citations

Generation and characterization of a competitive antagonist of human hepatocyte growth factor, HGF/NK1

1993 • 92 citations

Structure of prothrombin fragment 1 refined at 2.8 Å resolution

1988 • 85 citations

Deletion of kringle domains or the N-terminal hairpin structure in hepatocyte growth factor results in marked decreases in related biological activities

1991 • 84 citations

Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains

1992 • 71 citations

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Metreceptor

1994 • 67 citations

The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site

1998 • 60 citations

NK1, a Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is a Partial Agonist In Vivo

1998 • 58 citations

R_freeand theR_freeRatio. I. Derivation of Expected Values of Cross-Validation Residuals Used in Macromolecular Least-Squares Refinement

1998 • 49 citations

The structure of recombinant plasminogen kringle 1 and the fibrin binding site

1994 • 34 citations

Hepatotrophic growth factor in blood of mice treated with carbon tetrachloride

1990 • 30 citations

Cristobalite-Related Phases in the NaAlO₂–NaAlSiO₄ System. II. A Commensurately Modulated Cubic Structure

1998 • 24 citations