Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

Development by Self-Digestion

2004 • 3,562 citations

Autophagy as a Regulated Pathway of Cellular Degradation

2000 • 3,453 citations

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2004 • 2,265 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Autophagy as a cell death and tumor suppressor mechanism

2004 • 1,375 citations

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1997 • 1,016 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

2005 • 916 citations

Autophagosome Formation in Mammalian Cells.

2002 • 845 citations

Impaired Proteasome Function in Alzheimer's Disease

2000 • 795 citations

Studies on the mechanisms of autophagy: formation of the autophagic vacuole.

1990 • 789 citations

Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome

2000 • 764 citations

The mitochondrial-lysosomal axis theory of aging

2002 • 710 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

2000 • 522 citations

A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation

2001 • 511 citations

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

1990 • 415 citations

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis.

1997 • 388 citations

Neurons May Live for Decades with Neurofibrillary Tangles

1999 • 369 citations

Autophagy: a barrier or an adaptive response to cancer

2003 • 364 citations

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

2004 • 363 citations

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system

1995 • 359 citations

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.

1990 • 352 citations

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

1997 • 348 citations

Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down syndrome

2004 • 346 citations

Synaptic slaughter in Alzheimer's disease

2003 • 340 citations

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review.

2000 • 314 citations

A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy

2002 • 295 citations

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

2000 • 288 citations

Products of endocytosis and autophagy are retrieved from axons by regulated retrograde organelle transport.

1993 • 281 citations

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

2004 • 273 citations

Prelysosomal convergence of autophagic and endocytic pathways

1988 • 272 citations

The Autophagic and Endocytic Pathways Converge at the Nascent Autophagic Vacuoles

1997 • 265 citations

Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells

2003 • 258 citations

Autophagy regulates the processing of amino terminal huntingtin fragments

2003 • 250 citations

Autophagy in neurons: a review.

2002 • 247 citations

Autophagic Cell Death and Its Execution by Lysosomal Cathepsins.

2001 • 234 citations

Autophagic programmed cell death in Drosophila

2003 • 223 citations

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production

2003 • 221 citations

Quantitative measurement of intraorganelle pH in the endosomal-lysosomal pathway in neurons by using ratiometric imaging with pyranine.

1995 • 215 citations

Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

2002 • 207 citations

The calpains in aging and aging-related diseases

2003 • 204 citations

Biogenesis of Multilamellar Bodies via Autophagy

2000 • 177 citations

Induction of Autophagy Causes Dramatic Changes in the Subcellular Distribution of GFP‐Rab24

2002 • 173 citations

Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and Confusion

2001 • 169 citations

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1990 • 168 citations

Amino Acids as Regulators of Proteolysis

2003 • 163 citations

Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia

1967 • 163 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

Isolation of autophagic vacuoles from rat liver: morphological and biochemical characterization.

1982 • 150 citations

The endosomal-lysosomal system of neurons: new roles

1995 • 136 citations

Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes

1992 • 124 citations

Dynamic Organization of Endocytic Pathways in Axons of Cultured Sympathetic Neurons

1996 • 121 citations

Microglial cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plaque degradation

2000 • 116 citations

Biosynthetic FGF-2 is targeted to non-lipid raft microdomains following translocation to the extracellular surface of CHO cells

2002 • 105 citations

Re-Evaluation of the Structural Organization of Neuritic Plaques in Alzheimerʼs Disease

1993 • 102 citations

The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons

2004 • 96 citations

Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases Aβ Secretion

2002 • 96 citations

Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver.

1991 • 88 citations

The Lysosomal System in Neuronal Cell Death: A Review^a

1993 • 83 citations

Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies.

2003 • 78 citations

Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos

1989 • 76 citations

Colocalization of Lysosomal Hydrolase and β-Amyloid in Diffuse Plaques of the Cerebellum and Striatum in Alzheimerʼs Disease and Downʼs Syndrome

1996 • 73 citations

Diversity of Signaling Controls of Macroautophagy in Mammalian Cells.

2002 • 71 citations

The possible place of cathepsins and cystatins in the puzzle of Alzheimer disease

1996 • 67 citations

Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease.

1992 • 58 citations

Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative disease unless amyloid β-protein deposition is present

1993 • 55 citations

Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.

1989 • 53 citations

Evidence for retrograde degeneration of epinephrine neurons in Alzheimer's disease

1988 • 52 citations

An extensive network of PHFτ‐rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease

1994 • 49 citations

Caspase activation in the Alzheimer's disease brain: Tortuous and torturous

2002 • 45 citations

How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited

2002 • 44 citations

Effect of leupeptin on the autophagic vacuolar system of rat hepatocytes. Correlation between ultrastructure and degradation of membrane and cytosolic proteins.

1984 • 40 citations

Anterograde vs. retrograde degeneration of the nucleus basalis medialis in Alzheimer's disease.

1987 • 34 citations

Time course of vinblastine-induced autophagocytosis and changes in the endoplasmic reticulum in murine pancreatic acinar cells: a morphometric and biochemical study.

1996 • 29 citations

Changes in Cellular Ploidy and Autophagic Responsiveness During Rat Liver Carcinogenesis

1986 • 28 citations

The Cortical Neuritic Dystrophy of Alzheimer’s Disease: Nature, Significance, and Possible Pathogenesis

1995 • 23 citations