Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence

How MAP Kinases Are Regulated

1995 • 1,742 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Intracellular Signaling Pathways Activated by Neuropathic Factors

1996 • 958 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation

1998 • 675 citations

Interaction of a Receptor Tyrosine Kinase, EGF-R, with Caveolins

1997 • 658 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Gβγ Subunits Mediate Src-dependent Phosphorylation of the Epidermal Growth Factor Receptor

1997 • 456 citations

Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane

1996 • 449 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

Regulation of ERK ( Extracellular Signal Regulated Kinase), Part of the Neurotrophin Signal Transduction Cascade, in the Rat Mesolimbic Dopamine System by Chronic Exposure to Morphine or Cocaine

1996 • 295 citations

The proliferation of MAP kinase signaling pathways in yeast

1995 • 243 citations

G Protein-coupled Receptors Mediate Two Functionally Distinct Pathways of Tyrosine Phosphorylation in Rat 1a Fibroblasts

1997 • 233 citations

Sequestration of the δ Opioid Receptor

1996 • 198 citations

Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation

1997 • 183 citations

Angiotensin II-Induced Nuclear Targeting of the Angiotensin Type 1 (AT1) Receptor in Brain Neurons*

1998 • 173 citations

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

1989 • 155 citations

δ and κ Opioid Receptors Are Differentially Regulated by Dynamin-dependent Endocytosis When Activated by the Same Alkaloid Agonist

1997 • 139 citations

Opioid Modulation of Extracellular Signal‐Regulated Protein Kinase Activity Is Ras‐Dependent and Involves G_βγ Subunits

1998 • 121 citations

The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.

1996 • 115 citations

ERK3 Is a Constitutively Nuclear Protein Kinase

1996 • 92 citations

Kinase Suppressor of Ras Inhibits the Activation of Extracellular Ligand-regulated (ERK) Mitogen-activated Protein (MAP) Kinase by Growth Factors, Activated Ras, and Ras Effectors

1998 • 86 citations

Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation

1996 • 80 citations

Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain.

1981 • 78 citations

Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression

1997 • 75 citations

A Constitutively Internalizing and Recycling Mutant of the μ‐Opioid Receptor

1997 • 68 citations

Association of p120 ras GAP with endocytic components and colocalization with epidermal growth factor (EGF) receptor in response to EGF stimulation.

1996 • 65 citations

Nuclear Opioid Receptors Activate Opioid Peptide Gene Transcription in Isolated Myocardial Nuclei

1998 • 50 citations

Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain

1986 • 47 citations

Differential Interactions of the Growth Factor Receptor-bound Protein 2 N-SH3 Domain with Son of Sevenless and Dynamin

1998 • 44 citations

Angiotensin II-Induced Nuclear Targeting of the Angiotensin Type 1 (AT1) Receptor in Brain Neurons

1998 • 42 citations

Novel opioid binding sites associated with nuclei of NG108-15 neurohybrid cells

1993 • 41 citations

Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells

1994 • 38 citations

Stereospecific opiate-binding sites occur in coated vesicles

1985 • 35 citations

Agonist-Induced Desensitization and Down-Regulation of δ Opioid Receptors Alter the Levels of Their ¹²⁵I-β-Endorphin Cross-Linked Products in Subcellular Fractions from NG108-15 Cells

1996 • 16 citations

Opioid regulation of AP-1 DNA-binding activity in NG108-15 cells under conditions of opioid-receptor adaptation

1997 • 10 citations