Reactive Nitrogen Species and Cell Signaling

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

2001 • 1,391 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis

1999 • 804 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

2001 • 725 citations

Inhibition of JNK activation through NF-κB target genes

2001 • 720 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

2000 • 674 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

1996 • 665 citations

A Tale of Two Controversies

2002 • 484 citations

Oxidants/Antioxidants and COPD

2000 • 421 citations

Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase

2000 • 353 citations

Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

2001 • 353 citations

Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways

2000 • 337 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Reactive Nitrogen Species and Tyrosine Nitration in the Respiratory Tract

1999 • 308 citations

Air pollution and bronchitic symptoms in Southern California children with asthma.

1999 • 285 citations

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

1999 • 285 citations

Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of IκBα in NF-κB Activation by an Oxidative Stress

2000 • 251 citations

The c-Jun N-Terminal Kinase Cascade Plays a Role in Stress-Induced Apoptosis in Jurkat Cells by Up-Regulating Fas Ligand Expression

1998 • 238 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

Cytokine-induced Activation of Nuclear Factor-κB Is Inhibited by Hydrogen Peroxide through Oxidative Inactivation of IκB Kinase

2001 • 189 citations

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

1999 • 188 citations

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling

2001 • 182 citations

Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo.

1996 • 174 citations

Inhibition of Allergic Airway Inflammation in Mice Lacking Nitric Oxide Synthase 2

1999 • 160 citations

c-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents

2000 • 159 citations

Cell type-specific role for reactive oxygen species in nuclear factor-kappaB activation by Interleukin-1

2000 • 158 citations

A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs

2000 • 132 citations

Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes

2001 • 122 citations

NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

2001 • 121 citations

Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS

1997 • 107 citations

Blocking Caspase-3-Mediated Proteolysis of IKKβ Suppresses TNF-α-Induced Apoptosis

2001 • 107 citations

Nitrotyrosine formation in the airways and lung parenchyma of patients with asthma

1999 • 93 citations

Apoptosis Promotes a Caspase-induced Amino-terminal Truncation of IκBα That Functions as a Stable Inhibitor of NF-κB

1999 • 93 citations

Eosinophil Peroxidase Mediates Protein Nitration in Allergic Airway Inflammation in Mice

2001 • 68 citations

Toxicological mechanisms underlying oxidant pollutant-induced airway injury.

1998 • 61 citations

Nitrogen Dioxide Induces Death in Lung Epithelial Cells in a Density-Dependent Manner

2001 • 47 citations

Influence of exposure regimen on nitrogen dioxide-induced morphological changes in the rat lung

1986 • 47 citations

Effects of Nitrogen Dioxide Exposure on Clara Cell Proliferation and Morphology

1999 • 42 citations

c-FLIP efficiently rescues TRAF-2−/− cells from TNF-induced apoptosis

2002 • 33 citations

A comparative study of the pulmonary effects of NO2 in the rat and hamster.

1985 • 21 citations

Requirement for metabolic activation of acetylaminofluorene to induce multidrug gene expression.

1994 • 11 citations

Risk assessment of oxidant gases and particulate air pollutants: uncertainties and research needs.

1994 • 10 citations