Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Modulation of Vascular Smooth Muscle Contraction by the Endothelium

1986 • 643 citations

Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.

1989 • 632 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Blood Coagulation

1980 • 562 citations

Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

1989 • 558 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Angiotensin II Induces c-fos mRNA in Aortic Smooth Muscle

1989 • 401 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

1967 • 323 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Thrombin stimulates c-sis gene expression in microvascular endothelial cells.

1986 • 235 citations

Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells

1989 • 230 citations

Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.

1987 • 228 citations

Chemotactic response of monocytes to thrombin.

1983 • 221 citations

Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells.

1986 • 173 citations

Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.

1990 • 167 citations

Early agonist-mediated ionic events in cultured vascular smooth muscle cells. Calcium mobilization is associated with intracellular acidification.

1987 • 145 citations

Growth inhibition by protein kinase C late in mitogenesis

1987 • 133 citations

Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0→G1 transition of fibroblasts

1986 • 126 citations

Characterization of a mammalian smooth muscle myosin heavy chain cDNA clone and its expression in various smooth muscle types.

1988 • 118 citations

Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester‐sensitive pathway

1988 • 117 citations

Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.

1987 • 104 citations

Thrombin-Elicited Contractile Responses of Aortic Smooth Muscle

1985 • 86 citations

Initiation of proliferative events by human α‐thrombin requires both receptor binding and enzymic activity

1984 • 85 citations

Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C

1988 • 75 citations

Endothelial injury induced by thrombin or thrombi.

1975 • 54 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Growth‐promoting effects of esterolytically inactive thrombin on macrophages

1986 • 37 citations

Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells.

1988 • 35 citations

Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells

1990 • 34 citations

Vascular injuries induced by materials released from platelet-rich thrombus in vivo

1988 • 23 citations

Relationship of thrombin‐stimulated arachidonic acid release and metabolism to mitogenesis and phosphatidylinositol synthesis

1987 • 18 citations