Pharmacokinetic-pharmacodynamic modeling of the psychomotor stimulant effect of cocaine after intravenous administration: timing performance deficits.

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine

1979 • 1,136 citations

Comparison of four basic models of indirect pharmacodynamic responses

1993 • 780 citations

The pharmacology of cocaine related to its abuse.

1989 • 685 citations

Cocaine Plasma Concentration: Relation to Physiological and Subjective Effects in Humans

1978 • 335 citations

Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.

1989 • 244 citations

Physiological disposition and biotransformation of (3H) cocaine in acutely and chronically treated rats.

1976 • 206 citations

Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice.

1987 • 193 citations

Alcohol and cocaine interactions in humans.

1993 • 193 citations

Cocaine pharmacokinetics in humans

1981 • 165 citations

Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects.

1996 • 155 citations

Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice.

1987 • 142 citations

Acute tolerance to cocaine in humans

1988 • 124 citations

Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats

1997 • 108 citations

Correlation of Saliva Cocaine Levels with Plasma Levels and with Pharmacologic Effects after Intravenous Cocaine Administration in Human Subjects

1988 • 91 citations

Pharmacokinetic-Pharmacodynamic Relationships For Benzodiazepines

1996 • 89 citations

Acute effects of cocaine on spontaneous and discriminative motor functions: relation to route of administration and pharmacokinetics.

1991 • 79 citations

Cocaine: Pharmacokinetics and biotransformation in man

1989 • 78 citations

Behavioral pharmacology of local anesthetics: Reinforcing and discriminative stimulus effects

1982 • 57 citations

Tissue distribution of cocaine in the pregnant rat

1989 • 52 citations

Chronic oral cocaine self-administration: pharmacokinetics and effects on spontaneous and discriminative motor functions.

1991 • 52 citations

Effects of repeated administration of cocaine on schedule-controlled behavior of rats

1978 • 51 citations

The presence of cocaine and benzoylecgonine in rat cerebrospinal fluid after the intravenous administration of cocaine

1992 • 41 citations

Pharmacokinetics and bioavailability of midazolam after intravenous, subcutaneous, intraperitoneal and oral administration under a chronic food-limited regimen: relating DRL performance to pharmacokinetics

1996 • 40 citations

A COMPUTER ANALYSIS OF SERIAL INTERACTIONS IN SPACED RESPONDING¹

1966 • 37 citations

Pharmacologic interventions after an LD50 cocaine insult in a chronically instrumented rat model: Are beta-blockers contraindicated?

1991 • 33 citations

Cocaine inhalation in the rat: pharmacokinetics and cardiovascular response.

1991 • 31 citations

Simultaneous determination of cocaine and its metabolites with caffeine in rat serum microsamples by high-performance liquid chromatography

1990 • 30 citations

Relationship between the discriminative stimulus effects and plasma concentrations of intramuscular cocaine in rhesus monkeys

1995 • 29 citations

Behavioral effects of cocaine and its interaction with d-amphetamine and morphine in rats

1990 • 28 citations

Maternal and fetal brain and plasma levels of cocaine and benzoylecgonine after acute or chronic maternal intravenous administration of cocaine.

1994 • 27 citations

Differential reinforcement of low rate performance, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling: independent interaction of alprazolam and caffeine.

1997 • 23 citations

Pharmacokinetic-pharmacodynamic modeling of stimulatory and sedative effects of alprazolam: timing performance deficits.

1997 • 22 citations

Pharmacokinetic–pharmacodynamic modeling of the coexistence of stimulatory and sedative components for midazolam

1998 • 19 citations

Determination of cocaine and its metabolites in serum microsamples by high-performance liquid chromatography and its application to pharmacokinetics in rats

1997 • 19 citations

Alprazolam, caffeine and their interaction: relating DRL performance to pharmacokinetics

1996 • 19 citations

A pharmacokinetic–pharmacodynamic model of heart rate during cocaine administration in humans

1991 • 14 citations

Independent interaction of alprazolam and caffeine under chronic dose regimens on differential reinforcement of low-rate (DRL 45-s) performance

1997 • 12 citations

Simple apparatus for serial blood sampling in rodents permitting simultaneous measurement of locomotor activity as illustrated with cocaine

1997 • 11 citations