The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Transcriptional regulation of hemoglobin switching in chicken embryos.

1981 • 800 citations

Alteration of Cell-Surface Proteins by Viral Transformation and by Proteolysis

1973 • 666 citations

Extreme instability of myc mRNA in normal and transformed human cells.

1984 • 522 citations

Expression of the c- fos Gene and of an fos -Related Gene Is Stimulated by Platelet-Derived Growth Factor

1984 • 445 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 368 citations

High Stability of Messenger RNA in Growing Cultured Cells

1972 • 300 citations

Isolation of a Major Cell Surface Glycoprotein from Fibroblasts

1974 • 295 citations

Transcriptional Regulation of Hemoglobin Switching in Chicken Embryos

1981 • 265 citations

Activation of mouse genes in transformed cells

1983 • 252 citations

The molecular biology of platelet-derived growth factor

1983 • 252 citations

Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.

1984 • 229 citations

Identification of two human beta-tubulin isotypes.

1983 • 203 citations

Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.

1985 • 194 citations

Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

1983 • 161 citations

Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.

1978 • 149 citations

Transcripts regulated during normal embryonic development and oncogenic transformation share a repetitive element

1983 • 146 citations

Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.

1984 • 131 citations

Tumor promoters and kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA

1980 • 130 citations

Collagen Synthesis in Fibroblasts transformed by Oncogenic Viruses

1966 • 110 citations

SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion

1982 • 102 citations

Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.

1985 • 89 citations

DNA sequence comparison of the regulatory signals at the 5' end of the mouse and chick alpha 2 type I collagen genes.

1984 • 79 citations

The predominant secreted protein of transformed murine fibroblasts carries the lysosomal mannose 6-phosphate recognition marker.

1982 • 72 citations

Transcriptional control of the fibronectin gene in chick embryo fibroblasts transformed by Rous sarcoma virus.

1983 • 70 citations

Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.

1984 • 58 citations

Increased collagen synthesis in Kirsten sarcoma virus-transformed BALB 3T3 cells grown in the presence of dibutyryl cyclic AMP

1974 • 58 citations

Identification of a BALB/c-3T3 cell protein modulated by platelet-derived growth factor.

1983 • 51 citations

Identification of Two Human β-Tubulin Isotypes

1983 • 50 citations

Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.

1981 • 42 citations

Malignant Transformation and Tumor Promoter Treatment Increase Levels of a Transcript for a Secreted Glycoprotein

1985 • 41 citations

Regulation of the Transcript for a Lysosomal Protein: Evidence for a Gene Program Modified by Platelet-Derived Growth Factor

1985 • 36 citations

Tumor-promoting phorbol esters inhibit procollagen synthesis at a pretranslational level in JB-6 mouse epidermal cells.

1983 • 35 citations

Transcriptional induction of urokinase in cultured human kidney carcinoma cells by tetradecanoyl‐phorbol‐acetate

1984 • 22 citations

Identification of a BALB/c-3T3 Cell Protein Modulated by Platelet-Derived Growth Factor

1983 • 12 citations