Differential Roles for Wiskott-Aldrich Syndrome Protein in Immune Synapse Formation and IL-2 Production

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

The Immunological Synapse

2001 • 987 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins

2001 • 667 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

2003 • 536 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells

1997 • 376 citations

Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

1999 • 367 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Mechanism of Recruitment of WASP to the Immunological Synapse and of Its Activation Following TCR Ligation

2002 • 261 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

THE WISKOTT-ALDRICH SYNDROME PROTEIN (WASP): Roles in Signaling and Cytoskeletal Organization

1999 • 240 citations

Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

2004 • 197 citations

The Wiskott-Aldrich Syndrome Protein Acts Downstream of CD2 and the CD2AP and PSTPIP1 Adaptors to Promote Formation of the Immunological Synapse

2003 • 193 citations

Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells

2002 • 190 citations

Wiskott-Aldrich Syndrome Protein Regulates Lipid Raft Dynamics during Immunological Synapse Formation

2002 • 189 citations

Contingent Phosphorylation/Dephosphorylation Provides a Mechanism of Molecular Memory in WASP

2003 • 173 citations

Structure of the N-WASP EVH1 Domain-WIP Complex

2002 • 167 citations

WIP Deficiency Reveals a Differential Role for WIP and the Actin Cytoskeleton in T and B Cell Activation

2002 • 166 citations

SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site

2003 • 162 citations

WASP Recruitment to the T Cell:APC Contact Site Occurs Independently of Cdc42 Activation

2001 • 153 citations

The immunological synapse: integrins take the stage

2002 • 151 citations

Itk Functions to Control Actin Polymerization at the Immune Synapse through Localized Activation of Cdc42 and WASP

2003 • 131 citations

TCR, LFA-1, and CD28 Play Unique and Complementary Roles in Signaling T Cell Cytoskeletal Reorganization

1999 • 127 citations

The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency.

1985 • 102 citations

The regulation of actin remodeling during T‐cell–APC conjugate formation

2002 • 89 citations

Wiskott-Aldrich Syndrome

1963 • 81 citations

Molecular controls of antigen receptor clustering and autoimmunity

2001 • 63 citations

A Role for Wiskott-Aldrich Syndrome Protein in T-cell Receptor-mediated Transcriptional Activation Independent of Actin Polymerization

2001 • 61 citations

Analysis of specificity for antigen, Mls, and allogeneic MHC by transfer of T-cell receptor α- and β-chain genes

1988 • 52 citations

The T lymphocyte response to cytochrome c—II.

1980 • 43 citations

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

1998 • 31 citations

Overexpression of the Wiskott-Aldrich Syndrome Protein N-Terminal Domain in Transgenic Mice Inhibits T Cell Proliferative Responses Via TCR Signaling Without Affecting Cytoskeletal Rearrangements

2001 • 23 citations