Neutrophil Activation by Bacterial Lipoprotein Versus Lipopolysaccharide: Differential Requirements for Serum and CD14

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

1994 • 747 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 • 612 citations

Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures.

1983 • 474 citations

The Outer Membrane Proteins of Gram-Negative Bacteria: Biosynthesis, Assembly, and Functions

1978 • 457 citations

Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.

1982 • 444 citations

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

1991 • 425 citations

Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway

1996 • 325 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity.

1990 • 282 citations

The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen.

1975 • 273 citations

Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.

1992 • 273 citations

Lipopolysaccharide antagonists

1992 • 243 citations

CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol.

1997 • 237 citations

Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin

1999 • 236 citations

Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators

1994 • 232 citations

Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages.

1995 • 229 citations

A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.

1988 • 224 citations

CD14 and innate recognition of bacteria.

1995 • 224 citations

CD14 Is a Cell-activating Receptor for Bacterial Peptidoglycan

1996 • 222 citations

Neutrophil CD14: biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide.

1993 • 211 citations

Treponema pallidumandBorrelia burgdorferiLipoproteins and Synthetic Lipopeptides Activate Monocytic Cells via a CD14-Dependent Pathway Distinct from That Used by Lipopolysaccharide

1998 • 201 citations

Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties

1993 • 191 citations

Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses.

1995 • 177 citations

Neutralization and Transfer of Lipopolysaccharide by Phospholipid Transfer Protein

1996 • 176 citations

Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes.

1985 • 174 citations

Quantitation of surface CD14 on human monocytes and neutrophils

1997 • 168 citations

Activation of human neutrophils through L-selectin and Mac-1 molecules.

1995 • 159 citations

Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.

1991 • 158 citations

Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists.

1991 • 150 citations

Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B

1996 • 149 citations

The Role of CD14 in Signaling Mediated by Outer Membrane Lipoproteins ofBorrelia burgdorferi

1998 • 147 citations

Enzymatically Deacylated Lipopolysaccharide (LPS) Can Antagonize LPS at Multiple Sites in the LPS Recognition Pathway

1995 • 143 citations

Cutting Edge: Functional Characterization of the Effect of the C3H/HeJ Defect in Mice that Lack an Lps n Gene: In Vivo Evidence for a Dominant Negative Mutation

1999 • 142 citations

Integrins, ICAMs, and Selectins: Role and Regulation of Adhesion Molecules in Neutrophil Recruitment to Inflammatory Sites

1994 • 139 citations

Bacterial lipoprotein and lipopolysaccharide act synergistically to induce lethal shock and proinflammatory cytokine production.

1997 • 126 citations

Biological activities of native and recombinant Borrelia burgdorferi outer surface protein A: dependence on lipid modification

1994 • 121 citations

Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4.

1989 • 118 citations

Induction of Pro- and Anti-Inflammatory Cytokines byBorrelia burgdorferiLipoproteins in Monocytes Is Mediated by CD14

1999 • 116 citations

Stimulation of Human and Murine Adherent Cells by Bacterial Lipoprotein and Synthetic Lipopeptide Analogues

1988 • 116 citations

Borrelia burgdorferi outer membrane protein A induces nuclear translocation of nuclear factor-kappa B and inflammatory activation in human endothelial cells.

1996 • 111 citations

Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation.

1996 • 106 citations

Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity

1993 • 104 citations

Borrelia burgdorferi outer surface protein A (OspA) activates and primes human neutrophils.

1997 • 97 citations

Lipoprotein Release by Bacteria: Potential Factor in Bacterial Pathogenesis

1998 • 93 citations

Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-κB and regulation of cytokine production/action through β2 integrin in vivo

1996 • 90 citations

Activation of bone marrow‐derived mouse macrophages by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression

1990 • 86 citations

Outer surface lipoproteins of Borrelia burgdorferi activate vascular endothelium in vitro

1996 • 85 citations

Immunity to Lyme disease: protection, pathology and persistence

1996 • 70 citations

Identification of a Domain in Soluble CD14 Essential for Lipopolysaccharide (LPS) Signaling but Not LPS Binding

1995 • 70 citations

Lipopolysaccharide Binding Protein Participation in Cellular Activation by LPS

1995 • 62 citations

Immunohistological patterns of myeloid antigens: tissue distribution of CD13, CD14, CD16, CD31, CD36, CD65, CD66 and CD67

1993 • 61 citations

Studies on the mitogenic principle of the lipoprotein from the outer membrane of Escherichia coli

1977 • 61 citations

Neutrophil responses to lipopolysaccharide. Effect of adherence on triggering and priming of the respiratory burst.

1991 • 60 citations

Interaction of mitogenic bacterial lipoprotein and a synthetic analogue with mouse lymphocytes

1987 • 40 citations

Induction of Lymphocyte Proliferation and Membrane Changes by Lipopeptide Derivatives of the Lipoprotein from the Outer Membrane of Escherichia coli

1977 • 38 citations

A comparison of the effects of intact and deacylated lipopolysaccharide on human polymorphonuclear leukocytes.

1990 • 34 citations

Lipoprotein from Yersinia enterocolitica contains epitopes that cross-react with the human thyrotropin receptor.

1997 • 28 citations

Yersinia enterocoliticaEnvelope Proteins that are Crossreactive with the Thyrotropin Receptor (TSHR) also have B-cell Mitogenic Activity

1996 • 25 citations

Modulation of lipopolysaccharide-induced macrophage gene expression by Rhodobacter sphaeroides lipid A and SDZ 880.431

1993 • 20 citations

Inhibition of lipopolysaccharide-induced transcription factor Sp1 binding by spectrally pure diphosphoryl lipid A from Rhodobacter sphaeroides, protein kinase inhibitor H-8, and dexamethasone

1997 • 16 citations