STRUCTURE AND EXPRESSION OF HUMAN ALPHA-INTERFERON GENES

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.

1975 • 3,483 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences

1977 • 1,252 citations

Evolution of Repeated DNA Sequences by Unequal Crossover

1976 • 1,208 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Expression in Escherichia coli of a Chemically Synthesized Gene for the Hormone Somatostatin

1977 • 829 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

Expression of human immune interferon cDNA in E. coli and monkey cells

1982 • 703 citations

Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences

1981 • 657 citations

Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone

1977 • 532 citations

Human leukocyte interferon produced by E. coli is biologically active

1980 • 528 citations

A bacterial clone synthesizing proinsulin.

1978 • 515 citations

Evidence that types I and II interferons have different receptors

1981 • 511 citations

The structure of eight distinct cloned human leukocyte interferon cDNAs

1981 • 509 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

The structure of one of the eight or more distinct chromosomal genes for human interferon-α

1980 • 486 citations

Synthesis in E. coli of a polypeptide with human leukocyte interferon activity

1980 • 484 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

1980 • 341 citations

At Least Three Human Type α Interferons: Structure of α2

1980 • 274 citations

Human leukocyte and fibroblast interferons are structurally related

1980 • 273 citations

Genetic Recombination: Strand Transfer and Mismatch Repair

1978 • 270 citations

A family of structural genes for human lymphoblastoid (leukocyte-type) interferon

1980 • 253 citations

Human leukocyte interferon: production, purification to homogeneity, and initial characterization.

1979 • 233 citations

Chemical synthesis of genes for human insulin.

1978 • 223 citations

Heterogeneity of poly(I).poly(C)-induced human fibroblast interferon mRNA species

1980 • 199 citations

Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA

1979 • 191 citations

Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them.

1981 • 190 citations

Developmental Biology Using Purified Genes

1981 • 183 citations

Interferon: purification and initial characterization from human diploid cells.

1976 • 175 citations

A general method for maximizing the expression of a cloned gene.

1979 • 173 citations

Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase.

1981 • 164 citations

The nucleotide sequence of a cloned human leukocyte Interferon cDNA

1980 • 158 citations

Amino Terminal Sequence of the Major Component of Human Lymphoblastoid Interferon

1980 • 156 citations

Partial purification and characterization of human gamma (immune) interferon.

1981 • 145 citations

Structure of a chromosomal gene for human interferon β

1981 • 133 citations

Export of proteins from oocytes of Xenopus laevis

1979 • 131 citations

Leukocyte and fibroblast interferon genes are located on human chromosome 9.

1981 • 127 citations

Human fibroblast interferon gene lacks introns

1981 • 112 citations

Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II.

1979 • 110 citations

DNA Sequence of Two Closely Linked Human Leukocyte Interferon Genes

1981 • 110 citations

Mouse Interferons: Amino Terminal Amino Acid Sequences of Various Species

1980 • 108 citations

Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.

1979 • 101 citations

Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence

1978 • 93 citations

Evidence for a unique human fibroblast interferon (IFN-β₁) chromosomal gene, devoid of intervening sequences

1981 • 90 citations

Effect of Interferon-α1 from E. coli on Some Cell Functions

1980 • 86 citations

Molecular analysis of the human interferon-α gene family

1981 • 84 citations

Interferon activity produced by translation of human interferon messenger RNA in cell-free ribosomal systems and in Xenopus oöcytes.

1975 • 79 citations

DNA sequence of a major human leukocyte interferon gene.

1981 • 79 citations

Controlled transcription of a human α-interferon gene introduced into mouse L cells

1982 • 72 citations

The isolation and amino acid/sugar composition of human fibroblastoid interferon.

1979 • 71 citations

Nonglycosylated mouse L cell interferon produced by the action of tunicamycin.

1978 • 71 citations

Inducer-responsive expression of the cloned human interferonβ₁gene introduced into cultured mouse cells

1982 • 70 citations

Altered molecular species of human interferon produced in the presence of inhibitors of glycosylation.

1977 • 66 citations

Interferon Production in Hamsters Experimentally Infected with Rabies Virus.

1966 • 56 citations

Comparative antiviral efficiency of leukocyte and bacterially produced human α-interferon in rhesus monkeys

1981 • 47 citations

Comparisons of several biological and physicochemical properties of human leukocyte interferons produced by human leukocytes and by E. coli

1980 • 45 citations

Recent divergence from a common ancestor of human IFN-α genes

1982 • 44 citations

Interferon-gamma: success, structure and speculation

1982 • 34 citations

Elongation factor Tu isolated from Escherichia coli mutants altered in tufA and tufB

1980 • 31 citations