Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel.

Cyclophosphamide and Cisplatin Compared with Paclitaxel and Cisplatin in Patients with Stage III and Stage IV Ovarian Cancer

1996 • 2,766 citations

Cancer of the Ovary

2004 • 2,075 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer.

1997 • 662 citations

Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation.

1997 • 648 citations

European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion.

1994 • 639 citations

Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study.

1996 • 384 citations

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

1992 • 363 citations

Activity of Gemcitabine in Patients with Advanced Ovarian Cancer: Responses Seen Following Platinum and Paclitaxel

1996 • 253 citations

Topoisomerase I inhibitors: topotecan and irenotecan

1994 • 251 citations

Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma.

1996 • 248 citations

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

1992 • 231 citations

Long-term survival in ovarian cancer

1991 • 210 citations

Activity of Topotecan, a New Topoisomerase I Inhibitor, Against Human Tumor Colony-Forming Units In Vitro

1992 • 174 citations

Cytotoxic Effects of Topotecan Combined With Various Anticancer Agents in Human Cancer Cell Lines

1996 • 171 citations

Phase I Clinical and Pharmacology Study of Topotecan Given Daily for 5 Consecutive Days to Patients With Advanced Solid Tumors, With Attempt at Dose Intensification Using Recombinant Granulocyte Colony-Stimulating Factor

1993 • 135 citations

Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor

1993 • 123 citations

Carboplatin reinduction after taxane in patients with platinum-refractory epithelial ovarian cancer.

1995 • 122 citations

Topoisomerase I inhibitors: topotecan and irinotecan.

1996 • 69 citations

Combination chemotherapy in vitro with cis-dichlorodiammineplatinum(II).

1976 • 69 citations

European-Canadian randomized trial of Paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion

1998 • 66 citations

Chemotherapy in ovarian carcinoma: present role and future prospects.

1989 • 46 citations

Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cells

1990 • 41 citations

Treatment of ovarian cancer: current status.

1994 • 39 citations

Experience with independent radiological review during a topotecan trial in ovarian cancer

1997 • 30 citations

Paclitaxel retreatment in patients with platinum and paclitaxel resistant ovarian cancer.

1996 • 16 citations

Ifosfamide in the treatment of ovarian cancer.

1996 • 3 citations

Deleted Work

1955 • 0 citations