Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 • 816 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1998 • 768 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1998 • 686 citations

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

1999 • 668 citations

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

1998 • 658 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

2001 • 523 citations

Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids

1999 • 486 citations

Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis

1995 • 451 citations

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

1997 • 438 citations

Fish Oil Feeding Decreases Mature Sterol Regulatory Element-binding Protein 1 (SREBP-1) by Down-regulation of SREBP-1c mRNA in Mouse Liver

1999 • 375 citations

Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver

1998 • 369 citations

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

1999 • 364 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

1995 • 326 citations

Transport-Dependent Proteolysis of SREBP

1999 • 316 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

1995 • 295 citations

Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2

1996 • 274 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

2000 • 254 citations

Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene

1997 • 229 citations

Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins

1998 • 222 citations

Two CACGTG Motifs with Proper Spacing Dictate the Carbohydrate Regulation of Hepatic Gene Transcription

1995 • 209 citations

Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription

1999 • 196 citations

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1998 • 195 citations

Sterol Regulation of 3-Hydroxy-3-Methylglutaryl-coenzyme A Synthase Gene through a Direct Interaction Between Sterol Regulatory Element Binding Protein and the Trimeric CCAAT-binding Factor/Nuclear Factor Y

1998 • 184 citations

Dietary Regulation of Gene Expression: Enzymes Involved in Carbohydrate and Lipid Metabolism

1987 • 178 citations

Metabolic Regulation of Gene Transcription in Mammals

1995 • 160 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Nutritional regulation of the fatty acid synthase promoter in vivo : Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element

2000 • 158 citations

Identification of an insulin response element in the fatty acid synthase promoter.

1994 • 155 citations

Upstream Stimulatory Factor Binding to the E-box at −65 Is Required for Insulin Regulation of the Fatty Acid Synthase Promoter

1997 • 151 citations

Transcriptional Regulation of the ATP Citrate-lyase Gene by Sterol Regulatory Element-binding Proteins

2000 • 130 citations

Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1

1998 • 109 citations

Molecular Cloning and Functional Analysis of the Promoter of the Human Squalene Synthase Gene

1995 • 108 citations

Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo

2000 • 107 citations

NF-Y Has a Novel Role in Sterol-dependent Transcription of Two Cholesterogenic Genes

1995 • 107 citations

Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene

1996 • 102 citations

Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein

1998 • 77 citations

Structure of the rat L-type pyruvate kinase gene

1987 • 71 citations

Thyroid hormone and dietary carbohydrate interact to regulate rat liver S14 gene transcription and chromatin structure.

1990 • 69 citations

Multiple DNA Elements for Sterol Regulatory Element-Binding Protein and NF-Y Are Responsible for Sterol-Regulated Transcription of the Genes for Human 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase and Squalene Synthase

1998 • 65 citations

Identification of Diazepam-binding Inhibitor/Acyl-CoA-binding Protein as a Sterol Regulatory Element-binding Protein-responsive Gene

1998 • 61 citations

The CpG island in the 5′ region of the G6PD gene of man and mouse

1991 • 50 citations

Structural and functional analysis of the rat malic enzyme gene promoter.

1988 • 39 citations

Organization of the 5′ region of the rat ATP citrate lyase gene

1994 • 12 citations

Characterization of the 5′ flanking region of rat glucokinase gene

1989 • 11 citations

Induction of hepatic ATP-citrate lyase by insulin in diabetic rat--effects of insulin on the contents of enzyme and its mRNA in cytosol, and the transcriptional activity in nuclei

1994 • 11 citations

Structural and Functional Analysis of the Rat Malic Enzyme Gene Promoter

1988 • 10 citations