Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Circulating and Tissue Endothelin Immunoreactivity in Advanced Atherosclerosis

1991 • 967 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

1992 • 880 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

1994 • 574 citations

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

1992 • 546 citations

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.

1993 • 521 citations

Endothelin is a potent mitogen for rat vascular smooth muscle cells

1989 • 509 citations

Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium.

1992 • 357 citations

Growth factor activity of endothelin on vascular smooth muscle

1990 • 325 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Cloning and expression of human endothelin‐1 receptor cDNA

1991 • 282 citations

Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.

1992 • 230 citations

Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1

1994 • 214 citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

1990 • 187 citations

Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents

1994 • 152 citations

Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop

1994 • 141 citations

Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor

1984 • 123 citations

The endothelin peptides ET-1, ET-2, ET-3 and sarafotoxin S6b are co-mitogenic with platelet-derived growth factor for vascular smooth muscle cells

1990 • 118 citations

Adenosine receptor‐mediated changes in cyclic AMP production and DNA synthesis in cultured arterial smooth muscle cells

1985 • 117 citations

Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1

1994 • 90 citations

Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes

1989 • 85 citations

Endothelin stimulates protein synthesis in smooth muscle cells

1992 • 83 citations

Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin

1991 • 83 citations

Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature.

1993 • 83 citations

Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release

1991 • 73 citations

Endothelin-1 stimulates tyrosine phosphorylation and the activities of two mitogen-activated protein kinases in cultured vascular smooth muscle cells

1992 • 64 citations

Induction of Endothelin Secretion by Angiotensin II

1991 • 62 citations

Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein

1992 • 56 citations

A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta.

1993 • 53 citations

Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells

1991 • 53 citations

Endothelin receptor subtypes are coupled to adenylate cyclase via different guanyl nucleotide-binding proteins in vasculature

1993 • 33 citations

Type II phospholipase A2 recombinant overexpression enhances stimulated arachidonic acid release.

1991 • 3 citations