[40] Identification of T-cell epitopes and use in construction of synthetic vaccines

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

Estimation of effective interresidue contact energies from protein crystal structures: quasi-chemical approximation

1985 • 1,570 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Hydrophobicity of Amino Acid Residues in Globular Proteins

1985 • 1,168 citations

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

1987 • 637 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Intrinsic and Extrinsic Factors in Protein Antigenic Structure

1985 • 481 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

1987 • 429 citations

Determinant Selection and Macrophage Function in Genetic Control of the Immune Response

1978 • 389 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

1987 • 270 citations

H—2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide

1986 • 252 citations

Expression of the HTLV-III envelope gene by a recombinant vaccinia virus

1986 • 240 citations

Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals

1989 • 225 citations

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

1982 • 224 citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

1986 • 221 citations

The Chemistry and Mechanism of Antibody Binding to Protein Antigens

1988 • 212 citations

Modern approaches to vaccines

1985 • 194 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.

1988 • 186 citations

Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine.

1986 • 181 citations

Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum

1988 • 180 citations

T-cell-mediated association of peptide antigen and major histocompatibility complex protein detected by energy transfer in an evanescent wave-field

1986 • 178 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes.

1987 • 156 citations

Mapping of T cell epitopes using recombinant antigens and synthetic peptides.

1987 • 152 citations

Antigenic peptides recognized by T lymphocytes from AIDS viral envelope-immune humans

1988 • 146 citations

The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines.

1986 • 142 citations

Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein

1988 • 140 citations

Protein Antigenic Structures Recognized by T Cells; Potential Applications to Vaccine Design

1987 • 139 citations

Strong conformational propensities enhance T cell antigenicity.

1987 • 130 citations

The Structure of T-Cell Epitopes

1987 • 130 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

Identification of distinct predominant epitopes recognized by myoglobin-specific T cells under the control of different Ir genes and characterization of representative T cell clones.

1984 • 105 citations

Molecular mapping of a histocompatibility-restricted immunodominant T cell epitope with synthetic and natural peptides: implications for T cell antigenic structure.

1986 • 105 citations

The T lymphocyte response to cytochrome c. V. Determination of the minimal peptide size required for stimulation of T cell clones and assessment of the contribution of each residue beyond this size to antigenic potency.

1985 • 102 citations

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG

1988 • 101 citations

Immunological Priming with Synthetic Peptides of Foot-and-Mouth Disease Virus

1985 • 99 citations

Characterization of the murine TH response to influenza virus hemagglutinin: evidence for three major specificities.

1984 • 99 citations

The T Cell Response to the Malaria Circumsporozoite Protein: An Immunological Approach to Vaccine Development

1988 • 99 citations

On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes.

1987 • 94 citations

Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule.

1983 • 93 citations

Hydrophobic strip-of-helix algorithm for selection of T cell-presented peptides☆

1987 • 91 citations

Fusion Proteins with Multiple Copies of the Major Antigenic Determinant of Foot-and-Mouth Disease Virus Protect both the Natural Host and Laboratory Animals

1987 • 90 citations

T cell clones specific for an amphipathic alpha-helical region of sperm whale myoglobin show differing fine specificities for synthetic peptides. A multiview/single structure interpretation of immunodominance.

1986 • 86 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

An assessment of prediction methods for locating continuous epitopes in proteins

1988 • 83 citations

The T cell repertoire for recognition of a phylogenetically distant protein antigen. Peptide specificity and MHC restriction of staphylococcal nuclease-specific T cell clones.

1986 • 78 citations

T cell clones to two major T cell epitopes of myoglobin: effect of I-A/I-E restriction on epitope dominance.

1985 • 75 citations

Distinct recognition phenotypes exist for T cell clones specific for small peptide regions of proteins. Implications for the mechanisms underlying major histocompatibility complex-restricted antigen recognition and clonal deletion models of immune response gene defects.

1985 • 74 citations

Immunodominance in T lymphocyte recognition

1988 • 70 citations

T cell responses to cleaved rabies virus glycoprotein and to synthetic peptides.

1984 • 67 citations

Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis.

1988 • 62 citations

Synthetic peptides and β‐chain gene rearrangements reveal a diversified T cell repertoire for a λ light chain third hypervariable region

1986 • 61 citations

Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs.

1981 • 53 citations

The use of hydrophobic, alpha-helix-defined peptides in delineating the T cell determinant for pigeon cytochrome c.

1987 • 52 citations

Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein.

1988 • 48 citations

T cell recognition of ragweed allergen Ra3: Localization of the full T cell recognition profile by synthetic overlapping peptides representing the entire protein chain

1986 • 44 citations

Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells.

1988 • 43 citations

Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). VI. T cell fine specificity.

1985 • 38 citations

Structural basis of antigen recognition by T lymphocytes. Implications for vaccines.

1988 • 38 citations

The pigeon cytochrome c-specific T cell response of low responder mice. I. Identification of antigenic determinants on fragment 1 to 65.

1986 • 35 citations

Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.

1988 • 24 citations

Selection of class I MHC-restricted peptides with the strip-of-helix hydrophobicity algorithm

1988 • 23 citations

Features of T-cell recognition and antigen structure useful in the design of vaccines to elicit T-cell immunity

1988 • 20 citations

Analysis of lysozyme‐specific immune responses by synthetic peptides. I. Characterization of antibody and T cell‐mediated responses to the N‐terminal peptide of hen egg‐white lysozyme

1986 • 17 citations

Fine specificity of a BALB/c T cell clone directed against beef apo cytochrome c

1983 • 16 citations

Alloantigenic sites on class I major histocompatibility complex antigens: 61-69 region in the first domain of the H-2Kb molecule induces specific antibody and T cell responses.

1986 • 10 citations

Fine specificity analysis of lactate dehydrogenase B‐specific proliferating T cell clones: implications for the mechanism of alloreactivity

1985 • 9 citations