Peroxynitrite-mediated formation of free radicals in human plasma: EPR detection of ascorbyl, albumin-thiyl and uric acid-derived free radicals

Tissue sulfhydryl groups

1959 • 25,130 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

1994 • 1,348 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

1987 • 889 citations

Biologically relevant metal ion‐dependent hydroxyl radical generation An update

1992 • 862 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

Method of determining oxygen concentrations in biological media, suitable for calibration of the oxygen electrode

1970 • 382 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Peroxynitrite-induced luminol chemiluminescence

1993 • 371 citations

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

1994 • 369 citations

Paradoxical fate and biological action of peroxynitrite on human platelets.

1994 • 364 citations

Ascorbate free radical as a marker of oxidative stress: An EPR study

1993 • 360 citations

One- and two-electron oxidations of methionine by peroxynitrite.

1994 • 318 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart.

1994 • 300 citations

Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion

1994 • 287 citations

Inactivation of .alpha.1-proteinase inhibitor by peroxynitrite

1992 • 253 citations

Protein hydroperoxides can give rise to reactive free radicals

1995 • 238 citations

Free radical metabolite of uric acid.

1988 • 226 citations

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

1982 • 216 citations

Vascular free radical release. Ex vivo and in vivo evidence for a flow-dependent endothelial mechanism.

1994 • 215 citations

Biothiols in Health and Disease

1995 • 199 citations

The kinetics of the oxidation of l-ascorbic acid by peroxynitrite

1995 • 188 citations

Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates

1994 • 171 citations

Peroxynitrite‐mediated oxidation of albumin to the protein‐thiyl free radical

1994 • 146 citations

Interaction of nitrogen dioxide with human plasma Antioxidant depletion and oxidative damage

1992 • 141 citations

[15] Sulfur-centered free radicals

1990 • 134 citations

Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groups

1995 • 123 citations

Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide

1993 • 119 citations

Ascorbate- and dehydroascorbic acid-mediated reduction of free radicals in the human erythrocyte.

1991 • 99 citations

Ascorbate Oxidation: UV Absorbance of Ascorbate and ESR Spectroscopy of the Ascorbyl Radical as Assays for Iron

1990 • 90 citations

Inactivation of α₁ ‐antiproteinase by hydroxyl radicals The effect of uric acid

1989 • 87 citations

Ascorbyl radical as natural indicator of oxidative stress: quantitative regularities

1994 • 82 citations

Uric acid substantially enhances the free radical‐induced inactivation of alcohol dehydrogenase

1984 • 78 citations

Iron-induced ascorbate oxidation in plasma as monitored by ascorbate free radical formation. No spin-trapping evidence for the hydroxyl radical in iron-overloaded plasma

1992 • 75 citations

Radical-Induced Damage to Bovine Serum Albumin: Role of the Cysteine Residue

1993 • 63 citations

[33] Thiyl free radical metabolites of thiol drugs, glutathione, and proteins

1990 • 34 citations

Measurement of uric acid, ascorbic acid, and related metabolites in biological fluids

1984 • 32 citations

Ascorbate radical levels in human sera and rat plasma intoxicated with paraquat and diquat

1993 • 26 citations