Microglia: its development and role as a neuropathology sensor

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Cytology & cellular pathology of the nervous system

1965 • 1,037 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

1993 • 682 citations

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

1989 • 504 citations

Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate

1991 • 421 citations

Investigation of glial cells in semithin sections. I. Identification of glial cells in the brain of young rats

1973 • 406 citations

Identification of microglia in light and electron microscopy

1969 • 334 citations

Increased interleukin-6 expression by microglia from brain of aged mice

1999 • 324 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Investigation of glial cells in semithin sections. III. Transformation of subependymal cells into glial cells, as shown by radioautography after ³H‐thymidine injection into the lateral ventricle of the brain of young rats

1973 • 275 citations

Neuronal and microglial response in the retina of streptozotocin-induced diabetic rats

2000 • 266 citations

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1990 • 238 citations

Radioautographic investigation of gliogenesis in the corpus callosum of young rats II. Origin of microglial cells

1978 • 228 citations

Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro

1989 • 225 citations

Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum

1973 • 224 citations

Alzheimer's Disease: Biology, Diagnosis and Therapeutics

1998 • 201 citations

The Origin and Nature of Microglia

1981 • 178 citations

Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the ‘ameboid cells’ present in the corpus callosum of postnatal rats

1980 • 176 citations

Advances in Cellular Neurobiology

1983 • 173 citations

The complex of microglial cells and amyloid star in three-dimensional reconstruction

1990 • 162 citations

The microglia/macrophage response in the neonatal rat facial nucleus following axotomy

1998 • 160 citations

Alzheimer's disease : biology, diagnosis, and therapeutics

1996 • 151 citations

The response of neurons and microglia to blast injury in the rat brain

1995 • 135 citations

Studies of the ultrastructure and permeability of the blood-brain barrier in the developing corpus callosum in postnatal rat brain using electron dense tracers.

1994 • 130 citations

Amoeboid and ramified microglia: Their interrelationship and response to brain injury

1992 • 123 citations

Transformation of monocytes into amoeboid microglia in the corpus callosum of postnatal rats, as shown by labelling monocytes by carbon particles.

1979 • 120 citations

Immunocytochemical localization of CR3 complement receptors with OX-42 in amoeboid microglia in postnatal rats

1990 • 117 citations

Development of microglia in the postnatal rat hippocampus

1998 • 117 citations

Some aspects of amoeboid microglia in the corpus callosum and neighbouring regions of neonatal rats.

1976 • 117 citations

Origin, nature, and some functional considerations of intraventricular macrophages, with special reference to the epiplexus cells

1998 • 107 citations

A quantitative and morphometric study of the transformation of amoeboid microglia into ramified microglia in the developing corpus callosum in rats.

1992 • 93 citations

Immunohistochemical localization of beta‐amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy

1992 • 88 citations

Amoeboid Microglial Cells in the Corpus Callosum of Neonatal Rats

1974 • 87 citations

Light and electron microscopic demonstration of non-specific esterase in amoeboid microglial cells in the corpus callosum in postnatal rats: a cytochemical link to monocytes.

1982 • 84 citations

Study of the Transformation of Amoeboid Microglial Cells into Microglia Labelled with the Isolectin Griffonia simplicifolia in Postnatal Rats

1991 • 73 citations

Microglia in the human fetal spinal cord—patterns of distribution, morphology and phenotype

1999 • 70 citations

Light and electron microscopic demonstration of some lysosomal enzymes in the amoeboid microglia in neonatal rat brain.

1977 • 69 citations

Expression of major histocompatibility complex and leukocyte common antigens in amoeboid microglia in postnatal rats.

1991 • 64 citations

Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain.

1992 • 59 citations

Ultrastructural changes in the dorsal motor nucleus of monkey following bilateral cervical vagotomy

1986 • 59 citations

Macrophages/microglia as `sensors' of injury in the pineal gland of rats following a non-penetrative blast

1997 • 56 citations

Transformation of amoeboid microglial cells into microglia in the corpus callosum of the postnatal rat brain. An electron microscopical study.

1985 • 54 citations

Effects of melatonin on macrophages/microglia in postnatal rat brain

1999 • 52 citations

Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: Microglial/macrophage response and major histocompatibility complex class I and II expression

1999 • 50 citations

Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia

1999 • 45 citations

Microglia development in the quail cerebellum

1997 • 43 citations

Immunohistochemical study of amoeboid microglial cells in fetal rat brain.

1996 • 43 citations

Scanning electron microscopy of amoeboid microglial cells in the transient cavum septum pellucidum in pre- and postnatal rats.

1983 • 42 citations

Variation with age in the labelling of amoeboid microglial cells in rats following intraperitoneal or intravenous injection of a fluorescent dye.

1993 • 41 citations

A light microscopic demonstration of amoeboid microglia and microglial cells in the retina of rats of various ages.

1982 • 39 citations

A quantitative study of the differentiation of microglial cells in the developing cerebral cortex in rats.

1993 • 39 citations

Upregulation and induction of surface antigens with special reference to MHC class II expression in microglia in postnatal rat brain following intravenous or intraperitoneal injections of lipopolysaccharide.

1994 • 38 citations

Effects of intraneural injection ofRicinus communis agglutinin-60 into the rat vagus nerve

1987 • 38 citations

Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system

1991 • 37 citations

Microglial in Neurodegenerative Disorders: Emphasis on Alzheimer’s Disease

1997 • 37 citations

Brain macrophages in rats following intravenous labelling of mononuclear leucocytes with colloidal carbon.

1978 • 37 citations

Study in the changes of the proportions and numbers of the various glial cell types in the spinal cord of neonatal and young adult rats

1976 • 37 citations

The Effects of Subcutaneous Injections of Glucocorticoids on Amoeboid Microglia in Postnatal Rats.

1994 • 37 citations

Upregulation and induction of major histocompatibility complex class I and II antigens on microglial cells in early postnatal rat brain following intraperitoneal injections of recombinant interferon-gamma

1994 • 35 citations

Expression of induced nitric oxide synthase in amoeboid microglia in postnatal rats following an exposure to hypoxia

2000 • 34 citations

Transient expression of transferrin receptors and localisation of iron in amoeboid microglia in postnatal rats.

1995 • 34 citations

Labelling of Amoeboid Microglial Cells in Rats of Various Ages following an Intravenous Injection of Horseradish Peroxidase

1986 • 34 citations

Transsynaptic changes of neurons and associated microglial reaction in the spinal cord of rats following middle cerebral artery occlusion

1998 • 33 citations

Development of the Various Glial Cell Types in the Cerebral Cortex of Postnatal Rats

1989 • 32 citations

Down-regulation of membrane glycoprotein in amoeboid microglia transforming into ramified microglia in postnatal rat brain

1994 • 30 citations

Electron-Microscopic Identification of Amoeboid Microglia in the Spinal Cord of newborn rats

1976 • 30 citations

Neuronal degeneration and microglial reaction in the fetal and postnatal rat brain after transient maternal hypoxia

1998 • 29 citations

Induction of microglial and astrocytic response in the adult rat lumbar spinal cord following middle cerebral artery occlusion

1998 • 29 citations

A comparative Mac‐1 immunocytochemical and lectin histochemical study of microglial cells in the normal and athymic mice

1994 • 28 citations

Isolation and culture of amoeboid microglial cells from the corpus callosum and cavum septum pellucidum in postnatal rats.

1983 • 28 citations

Light and electron microscopic and cytochemical identification of amoeboid microglial cells in the brain of prenatal rats.

1983 • 28 citations

Influence of cortisone on amoeboid microglia and microglial cells in the corpus callosum in postnatal rats.

1982 • 26 citations

Heterogeneity of antigen expression and lectin labeling on microglial cells in the olfactory bulb of adult rats

1997 • 26 citations

Induction of major histocompatibility class II antigen on microglial cells in postnatal and adult rats following intraperitoneal injections of lipopolysaccharide

1997 • 25 citations

Expression of major histocompatibility complex antigens and CR3 complement receptors in activated microglia following an injection of ricin into the sciatic nerve in rats.

1992 • 25 citations

Expression of Fos-like immunoreactivity in the brain and spinal cord of rats following middle cerebral artery occlusion

1997 • 25 citations

Response of amoeboid and ramified microglial cells to lipopolysaccharide injections in postnatal rats - a lectin and ultrastructural study

1997 • 23 citations

Propentofylline attenuates microglial reaction in the spinal cord induced by middle cerebral artery occlusion

1999 • 22 citations

Infiltration of carbon-labelled monocytes into the dorsal motor nucleus following an intraneural injection of ricinus communis agglutinin-60 into the vagus nerve in rats.

1988 • 21 citations

Neuroglial response to neuron injury. A study using intraneural injection of ricinus communis agglutinin-60.

1989 • 21 citations

Labelling of amoeboid microglial cells in the supraventricular corpus callosum following the application of horseradish peroxidase in the cerebrum and spinal cord in rats.

1983 • 20 citations

Cerebrospinal fluid microglial antibodies: Potential diagnostic markers for immune mechanisms in Alzheimer's disease

1993 • 20 citations

Cytochemical localisation of 5'-nucleotidase in amoeboid microglial cells in postnatal rats.

1984 • 19 citations

Alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia

1994 • 19 citations

Properties of Activated Microglia and Pharmacologic Interference by Propentofylline

1998 • 18 citations

In vivo expression of inducible nitric oxide synthase in supraventricular amoeboid microglial cells in neonatal BALB/c and athymic mice

1997 • 17 citations

An immunohistochemical study of the intraventricular macrophages in induced hydrocephalus in prenatal rats following a maternal injection of 6-aminonicotinamide.

1996 • 17 citations

Ultrastructure and peroxidase cytochemistry of macrophages present in the retina of postnatal rats.

1981 • 16 citations

Induction of major histocompatibility complex class II antigen on amoeboid microglial cells in early postnatal rats following intraperitoneal injections of lipopolysaccharide or interferon-γ

1995 • 16 citations

Expression of major histocompatibility complex class II antigen on amoeboid microglial cells in early postnatal rat brain following intraperitoneal injections of lipopolysaccharide

1994 • 15 citations

The earliest invasion of macrophages into the developing brain and eye of the tree shrew Tupaia belangeri

1999 • 15 citations

Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions

1992 • 15 citations

Studies of the distribution and functional roles of transitory amoeboid microglial cells in developing rat brain using exogenous horseradish peroxidase as a marker.

1994 • 15 citations

Labelling of retinal microglial cells following an intravenous injection of a fluorescent dye into rats of different ages

2000 • 12 citations

A scanning and transmission electron microscopic study of amoeboid microglial cells in the prenatal rat brain following a maternal injection of 6-aminonicotinamide.

1984 • 11 citations

Microglial reaction in some CNS nuclei following nerves transection in BALB/c and interferon-γ gene knockout mice

1999 • 10 citations

Neural degeneration and non-neuronal cellular reactions in the hypoglossal nucleus following an intraneural injection of toxic ricin.

1989 • 10 citations

Emperipolesis of lymphoid cells in vagal efferent neurons following an intraneural injection of ricin into the vagus nerve in rats

1999 • 10 citations

An axosomatic and axodendritic multipolar neuron in the lizard cerebral cortex.

1994 • 10 citations

Microglia: immunoregulatory cells in the central nervous system.

2002 • 10 citations

Scanning electron microscopy of transitory subependymal cysts in the developing midbrain of postnatal rats.

1989 • 9 citations

Microglial cerebrospinal fluid antibodies

1996 • 8 citations

A qualitative and quantitative study of the glial cells in normal and athymic mice

1995 • 8 citations

Localisation of thiamine pyrophosphatase in the amoeboid microglial cells in the brain of postnatal rats.

1987 • 7 citations

Labeling of amoeboid microglial cells and intraventricular macrophages in fetal rats following a maternal injection of a fluorescent dye

1997 • 7 citations

Studies of lectin receptors of rat microglia in culture: receptor distribution and internalization

1999 • 7 citations

Effects of thymosin α1 on the development of amoeboid microglial cells in the corpus callosum of neonatal BALB/c and athymic mice

1997 • 6 citations

Response of amoeboid microglial cells to chloroquine injections in postnatal rats.

1996 • 3 citations

Effects of dexamethasone on antigen expressions and proliferation of amoeboid microglial cells in fetal rat brain.

1998 • 3 citations

Effects of interleukin-3 injection on supraventricular amoeboid microglial cells in neonatal BALB/c and athymic mice

1998 • 2 citations