Increased interleukin-6 expression by microglia from brain of aged mice

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

1993 • 1,009 citations

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.

1988 • 871 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Increase of plasma IL-6 concentration with age in healthy subjects

1992 • 393 citations

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

1997 • 374 citations

Altered antigen expression of microglia in the aged rodent CNS

1993 • 355 citations

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid

1989 • 259 citations

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

1988 • 246 citations

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

1998 • 246 citations

Complement and cytokine gene expression in cultured microglia derived from postmortem human brains

1995 • 243 citations

Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

1988 • 229 citations

Aging-associated Changes in Human Brain

1997 • 218 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

1992 • 195 citations

Glial Cytokines as Neuropathogenic Factors in HIV Infection

1994 • 147 citations

Interleukin-6 inhibits long-term potentiation in rat hippocampal slices

1997 • 144 citations

Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats

1994 • 128 citations

The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease

1996 • 114 citations

Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons

1995 • 94 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

Alzheimer's disease: pathology to potential treatments?

1992 • 59 citations

Comparative effect of IL-2 and IL-6 on morphology of cultured hippocampal neurons from fetal rat brain

1996 • 58 citations

Biology of the mononuclear phagocyte system of the central nervous system and HIV infection

1994 • 48 citations

Cerebellar granule neurons develop elevated calcium responses when treated with interleukin-6 in culture

1995 • 39 citations

Subchronic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS

1996 • 38 citations

Induction of interleukin-1β-converting enzyme (ICE) in murine microglia by lipopolysaccharide

1997 • 35 citations

Increased interleukin-6 production by cerebral cortical tissue of adult versus young mice

1996 • 27 citations

Central lipopolysaccharide elevates plasma IL-6 concentration by an alpha-adrenoreceptor-mediated mechanism

1997 • 24 citations

Production of nitric oxide and transforming growth factor-β in developing and adult rat brain

1995 • 14 citations