Upregulation and induction of surface antigens with special reference to MHC class II expression in microglia in postnatal rat brain following intravenous or intraperitoneal injections of lipopolysaccharide.

PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY

1974 • 3,882 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Functional plasticity of microglia: A review

1988 • 931 citations

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

1993 • 832 citations

Immunologically Privileged Sites

1978 • 815 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

1993 • 682 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Microglia in degenerative neurological disease

1993 • 594 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Macrophages and the Nervous System

1991 • 429 citations

Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon.

1985 • 397 citations

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

1992 • 395 citations

Altered antigen expression of microglia in the aged rodent CNS

1993 • 355 citations

Microglia are the major cell type expressing MHC class II in human white matter

1987 • 302 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Regulation of murine macrophage Ia antigen expression by an immune interferon-like lymphokine: inhibitory effect of endotoxin.

1982 • 193 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

Interferon-gamma: A Review

1989 • 156 citations

Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus

1993 • 155 citations

Immune modulation within the brain: recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ

1991 • 136 citations

Bacterial lipopolysaccharide-induced interferon-gamma production: roles of interleukin 1 and interleukin 2.

1986 • 130 citations

Immunocytochemical localization of CR3 complement receptors with OX-42 in amoeboid microglia in postnatal rats

1990 • 117 citations

Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain. A light and electron microscopical immunocytochemical study

1991 • 105 citations

Functional capacity of solid tissue transplants in the brain: evidence for immunological privilege

1985 • 102 citations

Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon

1988 • 101 citations

Interferon-gamma induction by lipopolysaccharide: dependence on interleukin 2 and macrophages.

1986 • 100 citations

Macrophage stimulation by bacterial lipopolysaccharides. II. Evidence for differentiation signals delivered by lipid A and by a protein rich fraction of lipopolysaccharides.

1978 • 95 citations

Immunological reactions induced by intracerebral transplantation: Evidence that host microglia but not astroglia are the antigen-presenting cells

1989 • 93 citations

Microglial involvement in experimental autoimmune inflammation of the central and peripheral nervous system

1993 • 87 citations

Expression of major histocompatibility complex and leukocyte common antigens in amoeboid microglia in postnatal rats.

1991 • 64 citations

Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain.

1992 • 59 citations

Regulation of MHC expression in vivo. Bacterial lipopolysaccharide induces class I and II MHC products in mouse tissues by a T cell-independent, cyclosporine-sensitive mechanism.

1988 • 59 citations

Comparison and quantitation of Ia antigen expression on cultured macroglia and ameboid microglia from Lewis rat cerebral cortex: analyses and implications

1989 • 56 citations

Wallerian degeneration induces Ia-antigen expression in the rat brain

1989 • 55 citations

Immunobiologic aspects of the brain and human gliomas. A review.

1980 • 54 citations

The identity of cells expressing MHC class II antigens in normal and pathological human brain

1992 • 54 citations

Modulation of macrophage Ia-expression by lipopolysaccharide. I. Induction of Ia expression in vivo.

1984 • 44 citations

Modulation of Ia-like antigen expression and antigen-presenting activity of human monocytes by endotoxin and zymosan A.

1981 • 44 citations

Expression of immunomolecules on microglial cells following neonatal sciatic nerve axotomy

1991 • 43 citations

Variation with age in the labelling of amoeboid microglial cells in rats following intraperitoneal or intravenous injection of a fluorescent dye.

1993 • 41 citations

Labelling of Amoeboid Microglial Cells in Rats of Various Ages following an Intravenous Injection of Horseradish Peroxidase

1986 • 34 citations

Expression of major histocompatibility complex antigens and CR3 complement receptors in activated microglia following an injection of ricin into the sciatic nerve in rats.

1992 • 25 citations

Induction of macrophage Ia expression by lipopolysaccharide and Listeria monocytogenes in congenitally athymic nude mice.

1987 • 24 citations

Major histocompatibility complex expression in brain of rats with graft-versus-host disease

1991 • 19 citations

Effects of cyclosporine on systemic MHC expression. Evidence that non-T cells produce interferon-gamma in vivo and are inhibitable by cyclosporine.

1988 • 7 citations