The Suppressor-mutator element and the evolutionary riddle of transposons

Selfish DNA: the ultimate parasite

1980 • 2,095 citations

Cytosine methylation and the ecology of intragenomic parasites

1997 • 1,906 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

The origin and behavior of mutable loci in maize

1950 • 1,592 citations

Nested Retrotransposons in the Intergenic Regions of the Maize Genome

1996 • 1,392 citations

DNA hypomethylation leads to elevated mutation rates

1998 • 935 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development.

1996 • 705 citations

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1998 • 628 citations

The origin of interspersed repeats in the human genome

1996 • 595 citations

Genome size and the proportion of repeated nucleotide sequence DNA in plants

1974 • 572 citations

Transposable elements as sources of variation in animals and plants

1997 • 569 citations

Transposable Elements and Genome Organization: A Comprehensive Survey of Retrotransposons Revealed by the Complete Saccharomyces cerevisiae Genome Sequence

1998 • 519 citations

TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA

1977 • 479 citations

Position effect variegation in Drosophila is associated with an altered chromatin structure.

1995 • 475 citations

Inactivation of gene expression in plants as a consequence of specific sequence duplication.

1994 • 462 citations

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned

1996 • 432 citations

Tiggers and DNA transposon fossils in the human genome.

1996 • 421 citations

Mutable Loci in Maize

1948 • 412 citations

The Adaptive Responses of Escherichia coli to a Feast and Famine Existence

1971 • 393 citations

Ancestral, Mammalian-wide Subfamilies of LINE-1 Repetitive Sequences

1995 • 382 citations

DNA methylation and imprinting: why bother?

1997 • 370 citations

Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions

1997 • 285 citations

Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis

1993 • 283 citations

The control of gene action in maize

1965 • 259 citations

DNA sequence insertion and evolutionary variation in gene regulation.

1996 • 251 citations

DNA methylation and the promotion of flowering by vernalization

1998 • 238 citations

GENE AMPLIFICATION AND GENOMIC PLASTICITY IN PROKARYOTES

1997 • 235 citations

Maize Transposable Elements

1991 • 230 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Molecular mechanisms in the developmental regulation of the maize Suppressor-mutator transposable element.

1988 • 207 citations

Molecular analysis of the En/Spm transposable element system of Zea mays

1986 • 205 citations

Epigenetic silencing of a foreign gene in nuclear transformants of Chlamydomonas.

1997 • 198 citations

Mobile elements inserted in the distant past have taken on important functions

1997 • 197 citations

Suppression of crossing-over by DNA methylation in Ascobolus

1998 • 190 citations

DNA methylation and plant development

1997 • 185 citations

Epigenetic phenomena in filamentous fungi: useful paradigms or repeat-induced confusion?

1997 • 180 citations

Meiotic Gene Conversion and Crossing Over Between Dispersed Homologous Sequences Occurs Frequently in Saccharomyces cerevisiae

1987 • 177 citations

The Unified Grass Genome: Synergy in Synteny

1997 • 173 citations

Genetic and Molecular Analysis of the Spm-dependent a-m2 Alleles of the Maize a Locus

1987 • 162 citations

Transgene Repeat Arrays Interact With Distant Heterochromatin and Cause Silencing in cis and trans

1997 • 159 citations

Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes.

1992 • 141 citations

Abnormal XY Interchange between a Novel Isolated Protein Kinase Gene, PRKY, and Its Homologue, PRKX, Accounts for One Third of All (Y+)XX Males and (Y-)XY Females

1997 • 140 citations

TnpA product encoded by the transposable element En-1 of Zea mays is a DNA binding protein.

1988 • 139 citations

Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression

1997 • 137 citations

Homologous Recombination and Gene Silencing in Plants

1994 • 137 citations

Reconstructing hominid Y evolution: X-homologous block, created by X-Y transposition, was disrupted by Yp inversion through LINE--LINE recombination

1998 • 135 citations

Paramutation and related allelic interactions

1997 • 135 citations

Transposon-mediated chromosomal rearrangements and gene duplications in the formation of the maize R-r complex.

1995 • 134 citations

RIGS (repeat-induced gene silencing) in Arabidopsis is transcriptional and alters chromatin configuration.

1996 • 126 citations

Allelic and ectopic recombination between Ty elements in yeast.

1988 • 125 citations

Paramutation at the R Locus in Maize

1958 • 123 citations

The Efficiency of Meiotic Recombination Between Dispersed Sequences in Saccharomyces cerevisiae Depends Upon Their Chromosomal Location

1996 • 121 citations

Is recombination confined to structural genes on the eukaryotic genome?

1977 • 108 citations

DNA rearrangement mediated by inverted repeats.

1996 • 105 citations

Excision of the En/Spm transposable element of Zea mays requires two element-encoded proteins.

1990 • 101 citations

Copy Number and Orientation Determine the Susceptibility of a Gene to Silencing by Nearby Heterochromatin in Drosophila

1996 • 94 citations

Epigenetic phenomena: Epigenetic phenomena: Paramutation and gene silencing in plants

1996 • 91 citations

Towards an understanding of position effect variegation

1989 • 90 citations

The Suppressor-Mutator System of Control of Gene Action in Maize

1958 • 90 citations

Mobility of the maize suppressor-mutator element in transgenic tobacco cells.

1989 • 86 citations

Epigenetic regulation of the maize Spm transposable element: Novel activation of a methylated promoter by TnpA

1994 • 85 citations

Anecdotal, Historical and Critical Commentaries on Genetics

1997 • 83 citations

Essential large transcripts of the maize Spm transposable element are generated by alternative splicing

1989 • 78 citations

Genetic and cytological studies of maize.

1957 • 71 citations

Is the Suppressor-mutator element controlled by a basic developmental regulatory mechanism?

1988 • 68 citations

The reduced expression of endogenous duplications (REED) in the maize R gene family is mediated by DNA methylation.

1995 • 67 citations

The Maize Transposable Element Ac Induces Recombination Between the Donor Site and an Homologous Ectopic Sequence

1997 • 66 citations

An uncertain silence

1997 • 65 citations

A Replicational Model for DNA Recombination between Direct Repeats

1996 • 65 citations

Mathematical models for the evolution of multigene families by unequal crossing over

1977 • 64 citations

The heritable activation of cryptic Suppressor-mutator elements by an active element.

1989 • 47 citations

Repeat-induced gene silencing: common mechanisms in plants and fungi.

1996 • 47 citations

The Contribution of One Component of a Control System to Versatility of Gene Expression

1971 • 46 citations

Further Studies of the Suppressor-Mutator System of Control of Gene Action in Maize

1961 • 45 citations

Spread of P Transposable Elements in Inbred Lines of Drosophila melanogaster

1989 • 42 citations

Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair

1998 • 40 citations

Factors affecting ectopic gene conversion in mice

1998 • 40 citations

Mutation detection by a two-hybrid assay

1998 • 39 citations

Maize Spm transposable element has an enhancer-insensitive promoter.

1993 • 38 citations

Gene silencing in mammalian cells by direct incorporation of electroporated 5-methyl-2?-deoxycytidine 5?-triphosphate

1991 • 36 citations

Slipped misalignment mechanisms of deletion formation: analysis of deletion endpoints

1998 • 35 citations

TnpA trans-activates methylated maize Suppressor-mutator transposable elements in transgenic tobacco.

1993 • 28 citations

Concerted formation of macromolecular Suppressor–mutator transposition complexes

1998 • 28 citations

Effect of CpG methylation on gene expression in transfected plant protoplasts

1990 • 27 citations

Epigenetic Silencing of Mu Transposable Elements in Maize

1996 • 25 citations

Defective I elements introduced intoDrosophila as transgenes can regulate reactivity and prevent I-R hybrid dysgenesis

1995 • 24 citations

Influence of Helix Formation oncis/transIsomerism of Xaa-Pro Bonds Flanking the Helical Segment

1996 • 19 citations

Selection and recombination in populations containing tandem multiplet genes

1979 • 17 citations

Epigenetic Regulation of the Maize Spm Transposable Element

1996 • 16 citations

Heritable Repression due to Paramutation in Maize

1968 • 13 citations

Evidence for gene silencing by DNA methylation in normal human diploid fibroblasts

1995 • 12 citations

A highly sensitive plant hybrid protein assay system based on the Spm promoter and TnpA protein for detection and analysis of transcription activation domains

1996 • 11 citations

Damage proneness induced by genomic DNA demethylation in mammalian cells cultivated in vitro

1997 • 10 citations

Maize Transposable Elements in Development and Evolution

1989 • 7 citations

Recombination in yeast and the recombinant DNA technology

1989 • 3 citations