Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Hippocampus: Modulation of Expression by Seizures and Anti-Excitotoxic Action

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Kainic acid seizures in the rat

1994 • 693 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

1991 • 578 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Kainic acid induced seizures: Neurochemical and histopathological changes

1983 • 526 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis

1991 • 462 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF

1993 • 383 citations

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

1997 • 348 citations

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

1992 • 346 citations

Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture

1995 • 338 citations

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

1993 • 334 citations

Amelioration of delayed neuronal death in the hippocampus by nerve growth factor

1991 • 333 citations

Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology

1995 • 329 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

1994 • 308 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

1993 • 218 citations

Glial changes following an excitotoxic lesion in the CNS—I. Microglia/macrophages

1991 • 215 citations

The neurotrophic action and signalling of epidermal growth factor

1997 • 198 citations

Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family.

1994 • 191 citations

Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay

1992 • 188 citations

Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization

1988 • 176 citations

TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration

1993 • 174 citations

Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

1992 • 174 citations

EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture

1991 • 173 citations

Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters

1996 • 166 citations

Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain

1997 • 160 citations

Heparin-Binding EGF-like Growth Factor: Characterization of Rat and Mouse cDNA Clones, Protein Domain Conservation across Species, and Transcript Expression in Tissues

1993 • 160 citations

Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger rna in response to kainate-induced excitation

1994 • 156 citations

Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons

1988 • 149 citations

Neuroprotective Signal Transduction: Relevance to Stroke

1997 • 148 citations

Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, in the rat hippocampus

1992 • 148 citations

Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.

1992 • 144 citations

Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture

1993 • 125 citations

Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-d-aspartate receptor activation

1993 • 122 citations

Seizures increase basic fibroblast growth factor mRNA in adult rat forebrain neurons and glia

1994 • 117 citations

Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA

1995 • 117 citations

PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways

1995 • 110 citations

Melatonin protects primary cultures of cerebellar granule neurons from kainate but not from N-methyl-d-aspartate excitotoxicity

1995 • 108 citations

Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat

1995 • 105 citations

Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction

1994 • 100 citations

Basic Fibroblast Growth Factor Selectively Increases AMPA‐Receptor Subunit GluR1 Protein Level and Differentially Modulates Ca²⁺ Responses to AMPA and NMDA in Hippocampal Neurons

1995 • 96 citations

Protection from 1-methyl-4-phenylpyridinium (MPP+) toxicity and stimulation of regrowth of MPP+-damaged dopaminergic fibers by treatment of mesencephalic cultures with EGF and basic FGF

1992 • 95 citations

Transforming growth factor-α in the mammalian brain

1989 • 94 citations

Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: Comparison with basic fibroblast growth factor

1991 • 94 citations

Cellular Localization of Transforming Growth Factor-? mRNA in Rat Forebrain

1993 • 83 citations

Epidermal growth factor and basic fibroblast growth factor: effects on an overlapping population of neocortical neurons in vitro

1990 • 80 citations

Biosynthesis and Processing by Phorbol Ester of the Cell Surface-Associated Precursor Form of Heparin-Binding EGF-like Growth Factor

1994 • 77 citations

Ischemia Induces the Expression of the Platelet-Derived Growth Factor-B Chain in Neurons and Brain Macrophages in vivo

1994 • 73 citations

Epidermal Growth Factor and Basic Fibroblast Growth Factor Protect Dopaminergic Neurons from Glutamate Toxicity in Culture

1995 • 71 citations

Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands.

1995 • 67 citations

Fast and widespread increase of basic fibroblast growth factor messenger RNA and protein in the forebrain after kainate-induced seizures

1993 • 65 citations

Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection

1994 • 63 citations

Interaction of Heparin-Binding EGF-Like Growth Factor (HB-EGF) with the Epidermal Growth Factor Receptor: Modulation by Heparin, Heparinase, or Synthetic Heparin-Binding HB-EGF Fragments

1992 • 61 citations

Purification and characterization of transmembrane forms of heparin-binding EGF-like growth factor.

1994 • 60 citations

Regional expression of transforming growth factor-α mRNA in the rat central nervous system

1991 • 58 citations

Effects of epidermal growth factor and basic fibroblast growth factor on generation of long-term potentiation in the dentate gyrus of fimbria-fornix-lesioned rats

1992 • 58 citations

Localization of immunoreactive epidermal growth factor receptor in neonatal and adult rat hippocampus

1993 • 55 citations

Influence of epidermal growth factor on long-term potentiation in the hippocampal slice

1989 • 55 citations

Seizure-Induced Increases in NGF mRNA Exhibit Different Time Courses across Forebrain Regions and Are Biphasic in Hippocampus

1994 • 53 citations

Expression of EGFR-, p75NGFR-, and PSTAIR (cdc2)-Like Immunoreactivity by Proliferating Cells in the Adult Rat Hippocampal Formation and Forebrain

1996 • 52 citations

Epidermal Growth Factor Prevents Oxygen‐triggered Apoptosis and Induces Sustained Signalling in Cultured Rat Cerebral Cortical Neurons

1995 • 52 citations

Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices

1991 • 52 citations

Regional distribution of heparin-binding epidermal growth factor-like growth factor mRNA and protein in adult rat forebrain

1996 • 47 citations

Purification of Heparin-Binding Epidermal Growth Factor-Like Growth Factor from Pig Uterine Luminal Flushings, and its Production by Endometrial Tissues1

1995 • 44 citations

Expression of EGF receptor mRNA in rat nigrostriatal system

1994 • 41 citations

Epidermal growth factor receptor in synaptic fractions of the rat central nervous system.

1992 • 33 citations

Production of Glycosylated Heparin-Binding EGF-like Growth Factor in HeLa Cells Using Vaccinia Virus

1996 • 32 citations

A subpopulation of striatal gabaergic neurons expresses the epidermal growth factor receptor

1995 • 31 citations

Heparin-binding epidermal growth factor-like growth factor, an immediate-early gene for mesangial cells, is up-regulated in the Thy-1.1 model.

1996 • 23 citations

In situ hybridization approaches to the study of the nervous system

1997 • 22 citations

Localization and characterization of epidermal growth-factor receptors in the developing rat medial septal area in culture

1994 • 21 citations

Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators

1994 • 21 citations

Chapter 11 Neurotrophic Factors and the Aging Brain

1997 • 18 citations

Carboxyl-terminal truncation of leucine76 converts heparin-binding EGF-like growth factor from a heparin-enhancible to a heparin-suppressible growth factor

1995 • 17 citations

Enhanced restoration of striatal dopamine concentrations by combined GM1 ganglioside and neurotrophic factor treatments

1995 • 13 citations