Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Role of cell shape in growth control

1978 • 2,434 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat

1988 • 499 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. II. Late ontogeny

1981 • 497 citations

K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.

1992 • 496 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Regulation of Nerve Growth Factor (NGF) Synthesis in the Rat Central Nervous System: Comparison between the Effects of Interleukin‐1 and Various Growth Factors in Astrocyte Cultures and in vivo

1990 • 369 citations

Light‐microscopic immunocytochemical localization of tyrosine hydroxylase in prenatal rat brain. I. Early ontogeny

1981 • 349 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Glial heterogeneity may define the three-dimensional shape of mouse mesencephalic dopaminergic neurones

1984 • 326 citations

Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture

1989 • 318 citations

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

1991 • 310 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

EGF and TGF-α stimulate retinal neuroepithelial cell proliferation in vitro

1991 • 286 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

The Physiology Of Transforming Growth Factor-α

1992 • 257 citations

K‐252 Compounds: Modulators of Neurotrophin Signal Transduction

1992 • 248 citations

Epidermal growth factor and transforming growth factor α

1989 • 247 citations

Human transforming growth factors induce tyrosine phosphorylation of EGF receptors

1981 • 244 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

The ontogeny of epidermal growth factor receptors during mouse development

1984 • 213 citations

Cells that Express Brain‐Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain

1991 • 208 citations

A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal

1986 • 203 citations

Expression of Ciliary Neurotrophic Factor and the Neurotrophins – Nerve Growth Factor, Brain‐Derived Neurotrophic Factor and Neurotrophin 3—in Cultured Rat Hippocampal Astrocytes

1992 • 197 citations

Epidermal growth factor stimulates DNA-synthesis of astrocytes in primary cerebellar cultures

1981 • 197 citations

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain

1988 • 189 citations

Regional distribution and developmental expression of epidermal growth factor and transforming growth factor-alpha mRNA in mouse brain by a quantitative nuclease protection assay

1992 • 188 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures.

1991 • 182 citations

The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth FACTOR-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture

1993 • 176 citations

Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization

1988 • 176 citations

EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture

1991 • 173 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells

1988 • 156 citations

Localization of immunoreactive epidermal growth factor receptors in human nervous system.

1988 • 155 citations

Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: Role of mesencephalic glia

1991 • 151 citations

Specific stimulation of in vitro maturation of mesencephalic dopaminergic neurones by striatal membranes

1981 • 151 citations

Density dependent proliferation of human glia cells stimulated by epidermal growth factor

1976 • 150 citations

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF)

1988 • 134 citations

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1992 • 129 citations

Mesencephalic type I astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture

1992 • 128 citations

Soluble striatal extracts enhance development of mesencephalic dopaminergic neurons in vitro

1986 • 124 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains

1992 • 124 citations

Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury

1988 • 106 citations

Astrocyte topography and tenascin/cytotactin expression: correlation with the ability to support neuritic outgrowth

1990 • 97 citations

Cerebellar target neurons provide a stop signal for afferent neurite extension in vitro

1992 • 97 citations

Transforming growth factor-α in the mammalian brain

1989 • 94 citations

Epidermal growth factor exerts neuronotrophic effects on dopaminergic and GABAergic CNS neurons: Comparison with basic fibroblast growth factor

1991 • 94 citations

Basic FGF is present in dopaminergic neurons of the ventral midbrain of the rat

1991 • 80 citations

Toxicity of 1‐Methyl‐4‐Phenylpyridinium for Rat Dopaminergic Neurons in Culture: Selectivity and Irreversibility

1990 • 76 citations

K-252b Selectively Potentiates Cellular Actions and trk Tyrosine Phosphorylation Mediated by Neurotrophin-3

1992 • 76 citations

Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor I

1990 • 69 citations

Epidermal growth factor and its receptor in the developing human nervous system

1991 • 67 citations

Stimulation of neuron survival by basic FGF and CNTF is a direct effect and not mediated by non-neuronal cells: evidence from single cell cultures

1992 • 66 citations

Transforming growth factor alpha, but not epidermal growth factor, promotes the survival of sensory neurons in vitro

1992 • 63 citations

Basic fibroblast growth factor regulates the ability of astrocytes to support hypothalamic neuronal survival in vitro

1991 • 63 citations

Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor

1990 • 60 citations

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

1982 • 60 citations

Region‐specifi neuro‐astroglial interactions: Ultrastructural study of the in vitro expression of neuronal polarity

1988 • 58 citations

Regional expression of transforming growth factor-α mRNA in the rat central nervous system

1991 • 58 citations

Attenuated Processing of Epidermal Growth Factor in the Face of Marked Degradation of Transforming Growth Factor-α

1989 • 56 citations

Epidermal Growth Factor Immunoreactive Material in the Rat Brain

1989 • 56 citations

Spatiotemporal increases in epidermal growth factor receptors following peripheral nerve injury

1992 • 54 citations

Localization of Cells Containing Transforming Growth Factor- α Precursor Immunoreactivity in the Basal Ganglia of the Adult Rat Brain

1990 • 53 citations

Epidermal growth factor and transforming growth factor ? induce c-fos gene expression in retinal muller cells in vivo

1991 • 51 citations

Liver epithelial cell migration induced by epidermal growth factor or transforming growth factor alpha is associated with changes in the gene expression of secreted proteins

1988 • 49 citations

Characterization of Epidermal Growth Factor Receptors in Astrocytic Glial and Neuronal Cells in Primary Culture*

1989 • 49 citations

Modification of anoxic neuronal injury by human recombinant epidermal growth factor and its possible mechanism

1990 • 40 citations

K-252b Is a Selective and Nontoxic Inhibitor of Nerve Growth Factor Action on Cultured Brain Neurons

1991 • 39 citations

Epidermal growth factor-induced survival and proliferation of neuronal precursor cells from embryonic rat mesencephalon

1992 • 38 citations

Visualization of growth factor receptor sites in rat forebrain

1988 • 36 citations

Cell Surface Recognition and Neuron-Glia Interactions

1991 • 36 citations

Preferential adhesion of brain astrocytes to laminin and central neurites to astrocytes

1987 • 34 citations

Epidermal growth factor inhibits the expression of myelin basic protein in oligodendrocytes

1989 • 32 citations

Epidermal growth factor stimulates the synthesis of cell‐attachment proteins in the human breast cancer cell line PMC42

1987 • 26 citations

Neuronal-glial interactions: Quantitation of astrocytic influences on development of catecholamine neurons

1989 • 26 citations

Transforming growth factor alpha and a PC12-derived growth factor induce neurites in PC12 cells and enhance the survival of embryonic brain neurons.

1990 • 25 citations

Fibroblast growth factor inhibits epidermal growth factor‐induced responses in rat astrocytes

1990 • 22 citations

Cell types and cell-substrate interactions in serum-free dissociated cultures of rat hypothalamus

1987 • 21 citations

The mechanism of cytosine arabinoside toxicity on quiescent astrocytes in vitro appears to be analogous to in vivo brain injury

1988 • 16 citations

Messenger ribonucleic acid for transforming growth factor-α, but not for epidermal growth factor, is expressed in fetal and neonatal mouse brain

1992 • 15 citations

Growth regulation of cancer

1989 • 3 citations