Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Beyond Cholesterol

1989 • 6,533 citations

Role of oxidized low density lipoprotein in atherogenesis.

1991 • 2,691 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

Increased superoxide anion production by immunologically activated and chemically elicited macrophages

1978 • 823 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Reductive alkylation of amino groups in proteins

1968 • 678 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

The superoxide‐generating oxidase of phagocytic cells

1991 • 564 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue Culture

1974 • 486 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.

1987 • 465 citations

The metabolism of very low density lipoprotein proteins. II. Studies on the transfer of apoproteins between plasma lipoproteins.

1972 • 434 citations

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

1986 • 417 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein.

1985 • 388 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Modified forms of low density lipoprotein and atherosclerosis

1993 • 348 citations

Superoxide initiates oxidation of low density lipoprotein by human monocytes.

1987 • 273 citations

Study of the Ferric Chloride Method for Determination of Total Cholesterol and Cholesterol Esters

1959 • 264 citations

Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients

1983 • 227 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Minimally modified low density lipoprotein is biologically active in vivo in mice.

1991 • 212 citations

Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation.

1989 • 200 citations

Lipoprotein-receptor interactions

1986 • 191 citations

The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein

1992 • 179 citations

Arterial wall oxygenation, oxyradicals, and atherosclerosis

1991 • 169 citations

The oxidative modification of low-density lipoproteins by macrophages

1990 • 169 citations

The influence of the triglyceride content of low density lipoprotein on the interaction of apolipoprotein B-100 with cells.

1988 • 154 citations

Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.

1988 • 148 citations

Varying susceptibility of different low density lipoproteins to oxidative modification.

1991 • 140 citations

Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation

1989 • 134 citations

Dietary Olive Oil Reduces Low-Density Lipoprotein Uptake by Macrophages and Decreases the Susceptibility of the Lipoprotein to Undergo Lipid Peroxidation

1993 • 131 citations

Cellular oxidative modification of low density lipoprotein does not require lipoxygenases.

1992 • 101 citations

Modified forms of low‐density lipoprotein and atherosclerosis

1993 • 94 citations

Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effects

1991 • 78 citations

Does superoxide radical have a role in macrophage-mediated oxidative modification of LDL?

1993 • 72 citations

Oxidative modification of low density lipoprotein (LDL) by activated human monocytes and the cell lines U937 and HL60

1988 • 71 citations

Immunolocalization of native antioxidant scavenger enzymes in early hypertensive and atherosclerotic arteries. Role of oxygen free radicals.

1992 • 70 citations

Preferential Inhibition of LDL Oxidation by the all-trans Isomer of β-Carotene in Comparison with 9-cis β-Carotene

1993 • 59 citations

Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDL

1989 • 56 citations

Increased susceptibility to activation and increased uptake of low density lipoprotein by cholesterol-loaded macrophages.

1992 • 54 citations

Electrophoresis and sudan black staining of lipoproteins on gelatinised cellulose acetate

1967 • 53 citations

Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells.

1992 • 52 citations

Phospholipase A2-modified LDL is taken up at enhanced rate by macrophages

1992 • 49 citations

A species comparison of low density lipoprotein heterogeneity in nonhuman primates fed atherogenic diets.

1988 • 48 citations

Oxidative modification of LDL: Comparison between cell-mediated and copper-mediated modification

1990 • 48 citations

Antioxidants and atherosclerosis

1992 • 46 citations

Intralipid infusion abolishes ability of human serum to cholesterol-load cultured macrophages.

1989 • 45 citations

Dual Ca2+ requirement for optimal lipid peroxidation of low density lipoprotein by activated human monocytes.

1993 • 41 citations

Cell-induced oxidation of LDL

1992 • 37 citations

Use of the β‐carotene rich alga Dunaliella Bardawil as a source of retinol

1986 • 33 citations

Reduced uptake of cholesterol esterase-modified low density lipoprotein by macrophages

1991 • 31 citations

Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein

1992 • 30 citations

Inhibition of macrophage-mediated low density lipoprotein oxidation by stimulated rat serosal mast cells.

1993 • 28 citations

Malondialdehyde affects the physico-chemical and biological characteristics of oxidized low density lipoprotein

1990 • 27 citations

The contribution of the macrophage receptor for oxidized LDL to its cellular uptake

1991 • 25 citations

Apolipoprotein E and lipoprotein lipase reduce macrophage degradation of oxidized very-low-density lipoprotein (VLDL), but increase cellular degradation of native VLDL

1992 • 25 citations

Lipolysis products promote the formation of complexes of very-low-density and low-density lipoproteins

1987 • 25 citations

Phospholipase D-modified low density lipoprotein is taken up by macrophages at increased rate. A possible role for phosphatidic acid.

1993 • 24 citations

Macrophages and ceroid in human atherosclerosis

1990 • 23 citations

Acute Effects of Dietary Cod Liver Oil and Cream on Plasma Lipoproteins

1986 • 22 citations

A high carbohydrate-fat free diet alters the proportion of heparin-bound VLDL in plasma and the expression of VLDL-apoB-100 epitopes

1990 • 19 citations

Platelet secretory substances enhance in vitro plasma coagulation.

1990 • 6 citations