Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Exosomes: composition, biogenesis and function

2002 • 4,840 citations

B lymphocytes secrete antigen-presenting vesicles.

1996 • 3,198 citations

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).

1987 • 2,537 citations

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

1998 • 2,078 citations

Antigen Presentation and T Cell Stimulation by Dendritic Cells

2002 • 1,860 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

2001 • 1,492 citations

Identification of a factor that links apoptotic cells to phagocytes

2002 • 1,323 citations

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

1985 • 1,153 citations

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

1998 • 1,153 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

2000 • 1,033 citations

Molecular Characterization of Dendritic Cell-Derived Exosomes

1999 • 1,005 citations

Malignant effusions and immunogenic tumour-derived exosomes

2002 • 904 citations

Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

2002 • 877 citations

Intestinal epithelial cells secrete exosome–like vesicles

2001 • 664 citations

Production and characterization of clinical grade exosomes derived from dendritic cells

2002 • 662 citations

HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice

1997 • 486 citations

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

2000 • 430 citations

Mast Cell-Dependent B and T Lymphocyte Activation Is Mediated by the Secretion of Immunologically Active Exosomes

2001 • 326 citations

Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL

2001 • 318 citations

Exosomes as Potent Cell-Free Peptide-Based Vaccine. II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection

2004 • 262 citations

Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells

2002 • 262 citations

Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes

2001 • 212 citations

Antigen-pulsed CD8α+ Dendritic Cells Generate an Immune Response after Subcutaneous Injection without Homing to the Draining Lymph Node

1999 • 161 citations

Class II MHC/Peptide Complexes Are Released from APC and Are Acquired by T Cell Responders During Specific Antigen Recognition

1999 • 154 citations

From synapses to immunological memory: the role of sustained T cell stimulation

2000 • 153 citations

Vesicles bearing MHC class II molecules mediate transfer of antigen from antigen-presenting cells to CD4+ T cells

1999 • 95 citations

Determination of the Relationship Between T Cell Responsiveness and the Number of MHC-Peptide Complexes Using Specific Monoclonal Antibodies

2000 • 93 citations

Transfer of antigen between dendritic cells in the stimulation of primary T cell proliferation

1998 • 89 citations

Dendritic Cell Maturation Overrules H-2d–Mediated Natural Killer T (Nkt) Cell Inhibition

2001 • 76 citations

A cautionary note on experimental artefacts induced by fetal calf serum in a viral model of pulmonary eosinophilia

2002 • 68 citations

Melan-A/MART-1-specific CD8 T cells: from thymus to tumor

2002 • 60 citations

Comparative analysis of the CD8+ T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice

2002 • 45 citations

Adherent-free generation of functional dendritic cells from purified blood monocytes in view of potential clinical use.

1998 • 37 citations