Na+-independent release of Ca2+ from rat heart mitochondria

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

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1967 • 1,785 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Safranine as a probe of the mitochondrial membrane potential

1976 • 786 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Relationship between configuration, function, and permeability in calcium-treated mitochondria.

1976 • 610 citations

Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin

1977 • 545 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 442 citations

Doxorubicin - Anticancer Antibiotics

1981 • 402 citations

The Sodium‐Induced Efflux of Calcium from Heart Mitochondria

1976 • 350 citations

The relationship between mitochondrial membrane permeability, membrane potential, and the retention of Ca2+ by mitochondria.

1980 • 288 citations

Adriamycin (NSC 123127) cardiomyopathy. An overview with determination of risk factors

1975 • 274 citations

[27] Measurements of cation transport with metallochromic indicators

1979 • 257 citations

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

1981 • 247 citations

Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex

1982 • 238 citations

The Steady State Maintenance of Accumulated Ca++ in Rat Liver Mitochondria

1965 • 232 citations

The role of glutathione in the retention of Ca2+ by liver mitochondria.

1984 • 223 citations

Pharmacokinetics and metabolism of adriamycin in man

1973 • 213 citations

Adriamycin metabolism in man. Evidence from urinary metabolites.

1976 • 194 citations

Intramitochondrial phospholipase activity and the effects of Ca2+ plus N-ethylmaleimide on mitochondrial function.

1979 • 189 citations

The reversible Ca2+-induced permeabilization of rat liver mitochondria

1986 • 174 citations

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 • 166 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

Effects of anticancer agents on the respiration of isolated mitochondria and tumor cells

1974 • 154 citations

Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity

1974 • 153 citations

Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment

1982 • 143 citations

Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria

1985 • 139 citations

Affinity of adriamycin to phospholipids a possible explanation for cardiac mitochondrial lesions

1976 • 128 citations

TRANSPORT AND ACCUMULATION OF CALCIUM IN MITOCHONDRIA

1978 • 117 citations

Adriamycin and daunorubicin disposition in the rabbit.

1974 • 115 citations

The control of Ca2+ release from heart mitochondria.

1981 • 95 citations

Synthetic approaches to adriamycin. 2. Degradation of daunorubicin to a nonasymmetric tetracyclic ketone and refunctionalization of the A ring to adriamycin

1977 • 82 citations

Methods in studying cardiac membranes

1984 • 76 citations

Daunorubicinol, a major metabolite of daunorubicin: isolation from human urine and enzymatic reactions.

1971 • 76 citations

Effects of atractyloside and palmitoyl coenzyme A on calcium transport in cardiac mitochondria

1977 • 73 citations

Regulation of Ca²⁺ Efflux from Kidney and Liver Mitochondria by Unsaturated Fatty Acids and Na⁺ Ions

1979 • 72 citations

Mechanism of alloxan-induced calcium release from rat liver mitochondria.

1985 • 69 citations

The effects of α-tocopherol on the toxicity, disposition, and metabolism of adriamycin in mice

1979 • 66 citations

Daunomycin and adriamycin metabolism via reductive glycosidic cleavage.

1972 • 62 citations

Effects of N-ethylmaleimide on the limited uptake of Ca2+, Mn2+, and Sr2+ by rat liver mitochondria.

1978 • 62 citations

The mitochondrial phosphate carrier reconstituted in liposomes is inhibited by doxorubicin

1983 • 59 citations

Inhibition of the cardiac mitochondrial calcium pump by adriamycin in vitro

1977 • 51 citations

A Comparison of the Cardiovascular Actions of Daunomycin, Adriamycin and N-Acetyldaunomycin in Hamsters and Monkeys

1971 • 47 citations

Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation

1986 • 46 citations

The stimulation of the release of Ca2+ from mitochondria by sodium ions and its inhibition

1982 • 35 citations

Marked inter-patient variation in adriamycin biotransformation to 7-deoxyaglycones: Evidence from metabolites identified in serum

1986 • 32 citations

Effect of whole-body hyperthermia on the disposition and metabolism of adriamycin in rabbits.

1978 • 32 citations

Cancer Chemotherapy 1979. Annual 1.

1980 • 28 citations

Effects of doxorubicin and its aglycone metabolite on calcium sequestration by rabbit heart, liver, and kidney mitochondria

1979 • 28 citations

Metabolism of adriamycin in hepatocytes isolated from the rat and the rabbit

1987 • 27 citations

Daunorubicin and adriamycin metabolism in the golden Syrian hamster

1973 • 22 citations

Divicine induces calcium release from rat liver mitochondria

1985 • 20 citations

Comparative cardiotoxicity and antitumour activity of doxorubicin (adriamycin) and 4′-deoxydoxorubicin and the relationship to in vivo disposition and metabolism in the target tissues

1987 • 19 citations

Biotransformations of daunorubicin aglycones by rat liver microsomes.

1984 • 16 citations

Distribution and metabolism of daunomycin, adriamycin, and N-acetyldaunomycin in the Syrian golden hamster

1972 • 14 citations

Radical dimer rescue of toxicity and improved therapeutic index of adriamycin in tumor-bearing mice.

1985 • 11 citations

Na+-independent, pyridine nucleotide-linked efflux of Ca2+ from preloaded rat heart mitochondria: induction by chlortetracycline

1987 • 2 citations