Kappa- and delta-opioids block sympathetically dependent hyperalgesia

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

1983 • 795 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.

1989 • 520 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Noradrenaline hyperalgesia is mediated through interaction with sympathetic postgahglionic neurone terminals rather than activation of primary afferent nociceptors

1986 • 286 citations

Substance P release from knee joint afferent terminals: modulation by opioids

1988 • 254 citations

Inhibition of neurogenic vasodilatation and plasma extravasation by substance P antagonists, somatostatin and [D-Met2, Pro5]enkephalinamide

1982 • 251 citations

Involvement of the mu-opiate receptor in peripheral analgesia

1989 • 172 citations

Selective antagonists at the opiate delta-receptor

1982 • 170 citations

The contribution of training to sensitivity in the nociceptive paw-withdrawal test

1989 • 163 citations

Multiple opiate receptors in peripheral tissue preparations

1981 • 150 citations

Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat

1987 • 144 citations

Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effect

1976 • 143 citations

Opioid control of the function of primary afferent substance P fibres

1985 • 139 citations

Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones

1979 • 134 citations

Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens

1980 • 129 citations

Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration.

1985 • 124 citations

Pharmacological profiles of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) on the mouse vas deferens preparation

1982 • 122 citations

Opiate receptors in cultures of fetal mouse dorsal root ganglia (DRG) and spinal cord: predominance in DRG neurites

1978 • 116 citations

Opioid modulation of non‐cholinergic neural bronchoconstriction in guinea‐pig in vivo

1988 • 111 citations

Characterization of the arachidonic acid metabolites mediating bradykinin and noradrenaline hyperalgesia

1988 • 106 citations

Opiate agonists inhibit neurogenic plasma extravasation in the rat

1981 • 103 citations

Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat

1989 • 103 citations

Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin

1988 • 94 citations

μ-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways

1987 • 91 citations

Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts.

1988 • 84 citations

Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen

1988 • 79 citations

Heterogeneous sensitivity of cultured dorsal root ganglion neurones to opioid peptides selective for µ - and δ -opiate receptors

1982 • 70 citations

Hyperalgesia onset latency suggests a hierarchy of action

1987 • 68 citations

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

1987 • 67 citations

Peripheral opiate receptor mechanisms

1981 • 58 citations

Presynaptic opioid receptor subtypes in the rabbit ear artery.

1985 • 53 citations

Calcium reverses the inhibitory action of morphine on neuroeffector transmission in the mouse vas deferens

1980 • 48 citations

Modification of guanine nucleotide-regulatory components in brain membranes. II. Relationship of guanosine 5'-triphosphate effects on opiate receptor binding and coupling receptors with adenylate cyclase

1984 • 46 citations

Characterization of rabbit ear artery opioid receptors using a δ-selective agonist and antagonist

1987 • 12 citations

Lack of cross-tolerance between morphine and Leu-enkephalin in the mouse vas deferens

1980 • 11 citations

Characterization of κ opioid receptors in the rabbit ear artery

1988 • 9 citations

Release of prostaglandins by bradykinin as an intrinsic mechanism of its algesic effect

1977 • 2 citations