Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.

The Hallmarks of Cancer

2000 • 27,569 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Tumor angiogenesis: past, present and the near future

2000 • 973 citations

Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I)

1998 • 773 citations

Host cyclooxygenase-2 modulates carcinoma growth

2000 • 693 citations

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

1998 • 677 citations

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

1997 • 673 citations

Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood

2000 • 658 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

2001 • 585 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

Molecular mechanisms of diverse actions of prostanoid receptors

1995 • 390 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis.

1997 • 297 citations

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

2000 • 263 citations

Fibroblast growth factors are required for efficient tumor angiogenesis.

2000 • 229 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Müller cells.

1998 • 201 citations

Cyclo‐oxygenase‐2 enhances basic fibroblast growth factor‐induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants

2000 • 199 citations

Suppression of Intestinal Polyposis inApc Δ716 Knockout Mice by an Additional Mutation in the Cytosolic Phospholipase A2Gene

2000 • 142 citations

FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury

1999 • 129 citations

Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis.

1998 • 127 citations