GABA and Glutamate Receptors as Biochemical Sites for Insecticide Action

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1994 • 716 citations

Action of Phenylpyrazole Insecticides at the GABA-Gated Chloride Channel

1993 • 477 citations

Structure and activity of avermectins and milbemycins in animal health

1995 • 440 citations

Mechanisms for Selective Toxicity of Fipronil Insecticide and Its Sulfone Metabolite and Desulfinyl Photoproduct

1998 • 353 citations

Fipronil insecticide: Novel photochemical desulfinylation with retention of neurotoxicity

1996 • 315 citations

Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin

1996 • 284 citations

Biochemistry and genetics of insecticide resistance

1985 • 257 citations

Avermectins: novel insecticides, acaricides and nematicides from a soil microorganism

1981 • 254 citations

Resistance to Avermectins: Extent, Mechanisms, and Management Implications

1995 • 241 citations

Molecular biology of insect neuronal GABA receptors

1997 • 219 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Haemonchus contortus: Selection at a Glutamate-Gated Chloride Channel Gene in Ivermectin- and Moxidectin-Selected Strains

1998 • 166 citations

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

1994 • 160 citations

Actions of the insecticide fipronil, on dieldrin‐sensitive and ‐resistant GABA receptors of Drosophila melanogaster

1995 • 156 citations

Doramectin — a potent novel endectocide

1993 • 154 citations

Inhibitory glutamate receptor channels

1996 • 146 citations

Insecticide action at the GABA‐gated chloride channel: Recognition, progress, and prospects

1993 • 131 citations

Ion channels as targets for insecticides.

1998 • 131 citations

Antagonism of Fipronil Toxicity by Piperonyl Butoxide and S, S, S-Tributyl Phosphorotrithioate in the German Cockroach (Dictyoptera: Blattellidae)

1997 • 127 citations

Fipronil: action at the GABA receptor.

1998 • 112 citations

Toxicity of Fipronil to Susceptible and Resistant Strains of German Cockroaches (Dictyoptera: Blattellidae) and House Flies (Diptera: Muscidae)

1997 • 108 citations

Toxicology, mode of action and target site-mediated resistance to insecticides acting on chloride channels

1993 • 104 citations

The Chemistry and Pharmacology of Avermectins

1992 • 103 citations

Picrotoxin Blockade of Invertebrate Glutamate‐Gated Chloride Channels: Subunit Dependence and Evidence for Binding Within the Pore

1999 • 103 citations

Actions of agonists and convulsant antagonists on a Drosophila melanogaster GABA receptor (Rdl) homo-oligomer expressed in Xenopus oocytes

1994 • 103 citations

Actions of anaesthetics and avermectin on GABA_A chloride channels in mammalian dorsal root ganglion neurones

1989 • 88 citations

Multiple Origins of Cyclodiene Insecticide Resistance in Tribolium castaneum (Coleoptera: Tenebrionidae)

1999 • 87 citations

Evolutionary Relationship of the Ligand-Gated Ion Channels and the Avermectin-Sensitive, Glutamate-Gated Chloride Channels

1997 • 86 citations

Pharmacological and biochemical properties of insect GABA receptors

1990 • 86 citations

Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors.

1995 • 84 citations

Inhibition of gamma-aminobutyric acid (GABA)-induced chloride uptake by gamma-BHC and heptachlor epoxide

1982 • 80 citations

Neuroreceptor mechanisms in insect gustation: a pharmacological approach

1994 • 78 citations

Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells ofAscaris; is this the site of anthelmintic action?

1990 • 76 citations

An Amino Acid Substitution in the Pore Region of a Glutamate-gated Chloride Channel Enables the Coupling of Ligand Binding to Channel Gating

1996 • 76 citations

Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.).

1991 • 73 citations

Cyclodiene resistance at the insect GABA receptor/chloride channel complex confers broad cross resistance to convulsants and experimental phenylpyrazole insecticides

1994 • 61 citations

Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons.

1997 • 60 citations

Antifeedant Effects of Some Novel Terpenoids on Chrysomelidae Beetles: Comparisons with Alkaloids on an Alkaloid-Adapted and Nonadapted Species

1997 • 51 citations

Invertebrate GABA and glutamate receptors: molecular biology reveals predictable structures but some unusual pharmacologies

1992 • 50 citations

Picrodendrin and related terpenoid antagonists reveal structural differences between ionotropic GABA receptors of mammals and insects

1998 • 47 citations

GABA receptors in insects

1990 • 38 citations

Characterization and comparative pharmacological studies of a functional γ-aminobutyric acid (GABA) receptor cloned from the tobacco budworm,Heliothis virescens (Noctuidae:Lepidoptera)

1998 • 38 citations

Actions of picrodendrin antagonists on dieldrin‐sensitive and ‐resistant Drosophila GABA receptors

1996 • 36 citations

Effects of [³H]‐BIDN, a novel bicyclic dinitrile radioligand for GABA‐gated chloride channels of insects and vertebrates

1997 • 34 citations

Characterization of [3H]ethynylbicycloorthobenzoate ([3H]EBOB) binding and the action of insecticides on the gamma-aminobutyric acid-gated chloride channel in cultured cerebellar granule neurons.

1996 • 33 citations

Functional assay for GABA receptor subtypes of a cockroach giant interneuron

1991 • 32 citations

Dieldrin and picrotoxinin modulation of GABA(A) receptor single channels.

1998 • 32 citations

Ivermectin Interactions with Invertebrate Ion Channels

1995 • 32 citations

Silphinene Derivatives: Their Effects and Modes of Action on Colorado Potato Beetle

1997 • 32 citations

A GABA‐activated chloride‐conductance not blocked by picrotoxin on spiny lobster neuromuscular preparations

1986 • 31 citations

A GabaB Receptor on an Identified Insect Motor Neurone

1995 • 26 citations

Actions of picrotoxinin analogues on an expressed, homo-oligorneric GABA receptor receptor of Drosophila melanogaster

1995 • 23 citations

Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes

1995 • 21 citations

Bicyclophosphorothionate antagonists exhibiting selectivity for housefly GABA receptors

1999 • 18 citations

Single Versus Multiple Origins of Insecticide Resistance: Inferences from the Cyclodiene Resistance Gene Rdl

1996 • 17 citations

Effects of Ivermectin on γ-Aminobutyric Acid and Glutamate-Gated Chloride Conductance in Arthropod Skeletal Muscle

1995 • 16 citations

Heterocyclic Insecticides Acting at the GABA-Gated Chloride Channel: 5-Alkyl-2-arylpyrimidines and -1,3-thiazines

1996 • 15 citations

Potentiation ofSuper-kdrresistance to deltamethrin and other pyrethroids by an intensifier (factor 161) on autosome 2 in the housefly (Musca domesticaL.)

1986 • 14 citations

Actions of cyclic esters, S-esters, and amides of phenyl- and phenylthiophosphonic acids on mammalian and insect GABA-gated chloride channels

1998 • 13 citations

Pharmacology of Contractile Responses in the Alimentary System of Caterpillars: Implications for Insecticide Development and Mode of Action

1999 • 12 citations

Synthesis of gem-difluoro-avermectin derivatives: Potent anthelmintic and anticonvulsant agents

1998 • 12 citations

Antifeedant discrimination thresholds for two populations of western corn rootworm

1998 • 10 citations

House fly head GABA‐gated chloride channel: [³ H] α‐Endosulfan binding in relation to polychlorocycloalkane insecticide action

1994 • 10 citations

Blocking actions of picrotoxinin analogues on insect (Periplaneta americana) GABA receptors

1994 • 9 citations

Role of cerebellar granule cell-specific GABAA receptor subtype in the differential sensitivity of [3H]ethynylbicycloorthobenzoate binding to GABA mimetics

1997 • 9 citations

Prolonged exposure to gaba activates GABA-gated chloride channels in the presence of channel-blocking convulsants

1991 • 9 citations

Cross‐resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist

1999 • 7 citations

Structural and Functional Characterization of Insect Genes Encoding Ligand-Gated Chloride-Channel Subunits

1995 • 7 citations

Biophysical Analysis of a Single Amino Acid Replacement in the Resistance to Dieldrin γ-Aminobutyric Acid Receptor

1995 • 7 citations

Insecticidal 1,3-Oxathianes and Their Oxides

1995 • 7 citations

Resistance to Avermectins in the House Fly, Musca domestica

1995 • 6 citations

Spirosultam LY219048: A new chemical class of insecticide acting upon the GABA receptor/chloride ionophore complex

1993 • 6 citations

Insecticide Binding Sites in the House Fly Head γ-Aminobutyric Acid Gated Chloride-Channel Complex

1995 • 6 citations

A native picrotoxin-resistant GABA-gated chloride channel receptor subtype in cockroach neurons

1999 • 5 citations

Insecticidal isomers of 4-tert-butyl-1-(4-ethynylcyclohexyl)-2,6,7-trioxabicyclo [2.2.2] octane and 5-tert-butyl-2-(4-ethynylcyclohexyl)-1,3-dithiane

1995 • 3 citations

Six-membered Cyclic Phosphonate GABA Antagonists, 2, 5-Disubstituted 1,3,2-Dioxaphosphorinanes

1995 • 2 citations

Chloride-Channel Gene Probes from Cyclodiene-Resistant and -Susceptible Strains of Blattella germanica

1995 • 1 citations