MyoD and myogenin act on the chicken myosin light-chain 1 gene as distinct transcriptional factors.

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

Myogenin gene disruption results in perinatal lethality because of severe muscle defect

1993 • 912 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.

1987 • 767 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

1989 • 662 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Alternative transcription and two modes of splicing result in two myosin light chains from one gene

1984 • 400 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

1989 • 326 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Making muscle in mammals

1992 • 292 citations

Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.

1990 • 278 citations

Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.

1991 • 275 citations

Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.

1989 • 274 citations

Use of the human elongation factor 1α promoter as a versatile and efficient expression system

1990 • 273 citations

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene

1990 • 261 citations

The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.

1988 • 236 citations

Paired MyoD-binding sites regulate myosin light chain gene expression.

1991 • 216 citations

Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos

1992 • 210 citations

Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.

1991 • 171 citations

An avian muscle factor related to MyoD1 activates muscle-specific promoters in nonmuscle cells of different germ-layer origin and in BrdU-treated myoblasts.

1989 • 162 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.

1990 • 157 citations

Site-Specific DNA Binding of Nuclear Factor I: Analyses of Cellular Binding Sites

1985 • 138 citations

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.

1992 • 117 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

Regulation of the mouse desmin gene: transactivation by MyoD, myogenin, MRF4 and Myf5

1993 • 104 citations

Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor.

1992 • 100 citations

A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors

1990 • 96 citations

Myogenin contains two domains conserved among myogenic factors.

1990 • 89 citations

Differential trans-activation of a muscle-specific enhancer by myogenic helix-loop-helix proteins is separable from DNA binding.

1991 • 89 citations

A developmental and tissue-specific enhancer in the mouse skeletal muscle acetylcholine receptor alpha-subunit gene regulated by myogenic factors.

1991 • 79 citations

Muscle-specific expression of the acetylcholine receptor alpha-subunit gene requires both positive and negative interactions between myogenic factors, Sp1 and GBF factors.

1993 • 62 citations

Different factors interact with myoblast-specific and myotube-specific enhancer regions of the human desmin gene

1993 • 59 citations

Differential trans-activation of muscle-specific regulatory elements including the mysosin light chain box by chicken MyoD, myogenin, and MRF4.

1992 • 57 citations

The 5′-flanking region of the mouse muscle nicotinic acetylcholine receptor β subunit gene promotes expression in cultured muscle cells and is activated by MRF4, myogenin and myoD

1992 • 54 citations

Expression of myogenic factors in denervated chicken breast muscle: isolation of the chicken Myf5 gene

1993 • 53 citations

Molecular cloning and nucleotide sequences of the complementary DNAs to chicken skeletal muscle myosin two alkali light chain mRNAs

1982 • 49 citations

The MRF4 activation domain is required to induce muscle-specific gene expression.

1992 • 44 citations

Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4.

1991 • 43 citations

Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer

1992 • 43 citations

Localization of mRNAs coding for CMD1, myogenin and the α-subunit of the acetylcholine receptor during skeletal muscle development in the chicken

1992 • 35 citations

Alternative multimeric structures affect myogenin DNA binding activity.

1992 • 30 citations

Upstream Regulatory Region for Inducible Expression of the Chicken Skeletal Myosin Alkali Light-Chain Gene

1988 • 19 citations