Pathways to Melanoma Development: Lessons from the Mouse

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

1994 • 860 citations

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

2001 • 825 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities

1998 • 722 citations

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

1999 • 693 citations

Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies.

2001 • 621 citations

MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes

1998 • 617 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Interaction between the retinoblastoma protein and the oncoprotein MDM2

1995 • 592 citations

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

2001 • 559 citations

Oncoprotein Networks

1997 • 532 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1994 • 439 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1997 • 405 citations

CDK inhibitors p18^INK4c and p27^Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

1998 • 399 citations

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

1998 • 387 citations

Neonatal sunburn and melanoma in mice

2001 • 383 citations

Cellular transformation by SV40 large T antigen: interaction with host proteins

2001 • 361 citations

Signaling Networks That Link Cell Proliferation and Cell Fate

2002 • 339 citations

The INK4a/ARF tumor suppressor: one gene—two products—two pathways

1998 • 286 citations

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

2000 • 281 citations

c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype.

1998 • 272 citations

A germline deletion of p14ARF but not CDKN2A in a melanoma-neural system tumour syndrome family

2001 • 271 citations

PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

2001 • 263 citations

Heterozygous Rb-1 delta 20/+mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.

1994 • 260 citations

Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

2000 • 238 citations

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

1994 • 221 citations

Transgenic mouse model for skin malignant melanoma

1998 • 212 citations

Murine Cutaneous Mastocytosis and Epidermal Melanocytosis Induced by Keratinocyte Expression of Transgenic Stem Cell Factor

1998 • 200 citations

Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development.

1996 • 199 citations

p16Ink4a in Melanocyte Senescence and Differentiation

2002 • 174 citations

A melanoma-associated germline mutation in exon 1β inactivates p14ARF

2001 • 173 citations

Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1

2002 • 166 citations

Human ARF binds E2F1 and inhibits its transcriptional activity

2001 • 165 citations

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

2001 • 165 citations

Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.

1996 • 164 citations

Invasive melanoma in Cdk4-targeted mice

2001 • 161 citations

Germ-line deletion involving the INK4 locus in familial proneness to melanoma and nervous system tumors.

1998 • 160 citations

Malignant melanoma in transgenic mice.

1991 • 151 citations

CDKN2A/p16 is inactivated in most melanoma cell lines.

1997 • 148 citations

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

2002 • 146 citations

Virtually 100% of melanoma cell lines harbor alterations at the DNA level withinCDKN2A, CDKN2B, or one of their downstream targets

1998 • 145 citations

Induction of p21^WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16^INK4a

1999 • 126 citations

Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.

1991 • 126 citations

Protein tyrosine kinases in malignant melanoma

2000 • 122 citations

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein

1999 • 120 citations

A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.

1994 • 116 citations

RhoA Stimulates p27Kip Degradation through Its Regulation of Cyclin E/CDK2 Activity

1999 • 114 citations

Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice.

2000 • 105 citations

Induction of melanoma in TPras transgenic mice

1999 • 100 citations

Standing and propagating wave oscillations in the anodic dissolution of nickle

1988 • 93 citations

Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene.

1998 • 82 citations

Development of Heritable Melanoma in Transgenic Mice

1998 • 79 citations

Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 HA‐ras gene regulated by a mouse tyrosinase promoter

1995 • 78 citations

From the Crest to the Periphery: Control of Pigment Cell Migration and Lineage Segregation

1993 • 78 citations

Selective deletion of exon 1β of thep19ARF gene in metastatic melanoma cell lines

1998 • 76 citations

Characterization and Histogenesis of Tumors in the Hairless Mouse Produced by Low-Dosage Incremental Ultraviolet Radiation

1984 • 74 citations

CDKN2A germline splicing mutation affecting both p16^ink4 and p14^arf RNA processing in a melanoma/neurofibroma kindred

2001 • 72 citations

PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines

2002 • 71 citations

CDKN2 mutations in melanoma.

1996 • 71 citations

Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.

1995 • 70 citations

Signal Transduction by the Receptor Tyrosine Kinase Ret

1998 • 67 citations

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

2000 • 65 citations

The genetics of cutaneous melanoma.

2000 • 64 citations

Transgenic mouse model of malignant skin melanoma.

1993 • 63 citations

Ultraviolet radiation-induced malignant skin melanoma in melanoma-susceptible transgenic mice.

1994 • 62 citations

Developmental Biology of Mammalian Melanocytes

1980 • 61 citations

Spotaneous Melanocytosis in Transgenic Mice

1996 • 61 citations

Metastatic cutaneous melanoma promoted by ultraviolet radiation in mice with transgene-initiated low melanoma susceptibility.

1998 • 55 citations

Inherited macrocephaly-hamartoma syndromes

1998 • 52 citations

Melanosis and associated tumors in transgenic mice.

1991 • 51 citations

Expression of cell cycle regulators in human cutaneous malignant melanoma

1999 • 45 citations

Screening of germline mutations in the CDK4, CDKN2C and TP53 genes in familial melanoma: A clinic‐based population study

1998 • 42 citations

Tumors of the retinal pigment epithelium metastasize to inguinal lymph nodes and spleen in tyrosinase-related protein 1/SV40 T antigen transgenic mice

1998 • 38 citations

Screening of germline mutations in theCDK4, CDKN2C andTP53 genes in familial melanoma: A clinic-based population study

1998 • 34 citations

Ectopic expression of ret results in microphthalmia and tumors in the retinal pigment epithelium

1999 • 24 citations

Transgenic Mouse Models for Tumors of Melanocytes and Retinal Pigment Epithelium

1999 • 20 citations

Signal Transduction by the Oncogenic Receptor Tyrosine Kinase Xmrk in Melanoma Formation of Xiphophorus

1997 • 19 citations

Differences in latency and inducibility of mouse skin melanomas depending on the age and anatomic site of the skin.

1998 • 14 citations

No evidence of a role for activating CDK2 mutations in melanoma

2001 • 9 citations

Proliferation and Neoplastic Transformation of Pigment Cells in Metallothionein/ret Transgenic Mice

1992 • 7 citations