Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation.

1985 • 886 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.

1990 • 522 citations

Amatoxins, Phallotoxins, Phallolysin, and Antamanide: The Biologically Active Components of PoisonousAmanitaMushroom

1978 • 464 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

Mechanisms of actin rearrangements mediating platelet activation.

1992 • 413 citations

Identification of membrane proteins mediating the interaction of human platelets

1980 • 383 citations

Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor.

1992 • 323 citations

Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets

1985 • 253 citations

Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes.

1985 • 236 citations

The Platelet Cytoskeleton

1993 • 235 citations

The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments.

1991 • 233 citations

Changes in the cytoskeletal structure of human platelets following thrombin activation.

1981 • 232 citations

Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet Aggregation

1995 • 216 citations

Role of phosphorylation in mediating the association of myosin with the cytoskeletal structures of human platelets.

1982 • 195 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

Ultrastructure of clots during isometric contraction.

1982 • 176 citations

Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. Identification of one of the glycoproteins as glycoprotein Ib.

1985 • 173 citations

Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound [see comments]

1991 • 172 citations

On the association of glycoprotein Ib and actin-binding protein in human platelets.

1985 • 165 citations

Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses.

1986 • 164 citations

Identification of a membrane skeleton in platelets.

1988 • 161 citations

Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane systems of activated human platelets

1990 • 154 citations

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

1994 • 148 citations

Myosin phosphorylation in intact platelets.

1981 • 148 citations

A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen

1987 • 146 citations

Separable assembly of platelet pseudopodal and contractile cytoskeletons

1982 • 140 citations

Thrombin-induced changes in platelet membrane glycoproteins Ib, IX, and IIb-IIIa complex

1987 • 124 citations

Identification of a region in the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX complex that binds to purified actin-binding protein.

1992 • 114 citations

Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

1986 • 101 citations

Differential redistribution of platelet glycoproteins Ib and IIb-IIIa after plasmin stimulation [published erratum appears in Blood 1991 Jul 15;78(2):545]

1991 • 89 citations

Plasmin-induced redistribution of platelet glycoprotein Ib

1990 • 80 citations

The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible

1994 • 79 citations

Reversal of thrombin-induced myosin phosphorylation and the assembly of cytoskeletal structures in platelets by the adenylate cyclase stimulants prostaglandin D2 and forskolin.

1983 • 76 citations

Interaction of purified actin-binding protein with the platelet membrane glycoprotein Ib-IX complex.

1991 • 75 citations

Contractile properties of actomyosin from human blood platelets

1978 • 74 citations

Phosphorylation of platelet actin-binding protein during platelet activation

1982 • 73 citations

The platelet glycoprotein Ib-IX complex.

1991 • 70 citations

Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.

1988 • 63 citations

Thrombin decreases von Willebrand factor binding to platelet glycoprotein Ib

1988 • 57 citations

Two thrombin-activated Ca2+ channels in human platelets.

1992 • 55 citations

Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation

1992 • 51 citations

Thrombin-Induced Down-Regulation of the Platelet Membrane Glycoprotein Ib-IX Complex

1992 • 50 citations

Arrangements of actin filaments in the cytoskeleton of human platelets.

1984 • 50 citations

Thymosin beta 4 (T beta 4) in activated platelets.

1993 • 45 citations

The organization of microfilaments in spreading platelets: A comparison with fibroblasts and glial cells

1984 • 42 citations

Von Willebrand factor and fibrinogen

1993 • 39 citations

Concurrent measurement of platelet ionized calcium concentration and aggregation: Studies with the Lumiaggregometer

1985 • 38 citations

von Willebrand factor bound to glycoprotein Ib is cleared from the platelet surface after platelet activation by thrombin

1992 • 38 citations

Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading. An immunoelectron microscopy study.

1992 • 38 citations

Persistence of mobile receptors on surface- and suspension-activated platelets.

1994 • 29 citations

Reversibility of thrombin‐induced decrease in platelet glycoprotein Ib function

1993 • 27 citations

Formation and contraction of a microfilamentous shell in saponin-permeabilized platelets.

1991 • 27 citations

Quasi-simultaneous measurement of ionized calcium and alpha-granule release in individual platelets

1991 • 24 citations

Binding of Human Platelet Glycoprotein lb and Actin to Fragments of Actin-Binding Protein

1992 • 14 citations