β-lactams against methicillin-resistant

Staphylococcus aureusInfections

1998 • 5,749 citations

Whole genome sequencing of meticillin-resistant Staphylococcus aureus

2001 • 1,932 citations

Exotoxins of Staphylococcus aureus

2000 • 1,624 citations

Genome and virulence determinants of high virulence community-acquired MRSA

2002 • 1,358 citations

Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin

1997 • 1,330 citations

Autoinduction and signal transduction in the regulation of staphylococcal virulence

2003 • 1,241 citations

Infection with Vancomycin-ResistantStaphylococcus aureusContaining thevanAResistance Gene

2003 • 1,091 citations

A New Class of Genetic Element, Staphylococcus Cassette Chromosome mec , Encodes Methicillin Resistance in Staphylococcus aureus

2000 • 977 citations

Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus

2001 • 949 citations

Multimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs

1998 • 615 citations

Novel Type of Staphylococcal Cassette Chromosome mec Identified in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains

2002 • 591 citations

Structural basis for the β lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

2002 • 414 citations

Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC

2003 • 414 citations

An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci

2001 • 370 citations

The role of beta-lactamase in staphylococcal resistance to penicillinase-resistant penicillins and cephalosporins

1986 • 330 citations

The Basis for Resistance to β-Lactam Antibiotics by Penicillin-binding Protein 2a of Methicillin-resistant Staphylococcus aureus

2004 • 238 citations

In Vitro and In Vivo Properties of Ro 63-9141, a Novel Broad-Spectrum Cephalosporin with Activity against Methicillin-Resistant Staphylococci

2001 • 215 citations

Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus

1994 • 200 citations

Molecular structures of penicillin-binding proteins and β-lactamases

1994 • 183 citations

Pathogenicity and resistance islands of staphylococci

2001 • 157 citations

Increased amounts of a novel penicillin-binding protein in a strain of methicillin-resistant Staphylococcus aureus exposed to nafcillin.

1985 • 108 citations

FemABX Peptidyl Transferases: a Link between Branched-Chain Cell Wall Peptide Formation and β-Lactam Resistance in Gram-Positive Cocci

2003 • 108 citations

Expression of resistance to methicillin

1994 • 105 citations

Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers

2004 • 103 citations

Abnormal Peptidoglycan Produced in a Methicillin-Resistant Strain of Staphylococcus aureus Grown in the Presence of Methicillin: Functional Role for Penicillin-Binding Protein 2A in Cell Wall Synthesis

1993 • 96 citations

BAL9141, a Novel Extended-Spectrum Cephalosporin Active against Methicillin-Resistant Staphylococcus aureus in Treatment of Experimental Endocarditis

2002 • 93 citations

Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus

1986 • 82 citations

Antimicrobial Resistance inStaphylococcus aureusin Australian Teaching Hospitals, 1989-1999

2003 • 74 citations

-Lactam Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus

1991 • 72 citations

Interactions between Penicillin-Binding Proteins (PBPs) and Two Novel Classes of PBP Inhibitors, Arylalkylidene Rhodanines and Arylalkylidene Iminothiazolidin-4-ones

2004 • 72 citations

PBP 2a Mutations Producing Very-High-Level Resistance to Beta-Lactams

2004 • 70 citations

Comparative Efficacy of Amoxicillin-Clavulanate, Cloxacillin, and Vancomycin Against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Endocarditis in Rats

1989 • 67 citations

Beta-Lactam-beta-lactamase-inhibitor combinations are active in experimental endocarditis caused by beta-lactamase-producing oxacillin-resistant staphylococci

1991 • 55 citations

In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for the penicillin-binding protein PBP 2a

1995 • 54 citations

Binding Affinity for Penicillin-Binding Protein 2a Correlates with In Activity of -Lactan Antibiotics against Methicillin-Resistant Staphylococcus aureus

1990 • 53 citations

TOC-39, a novel parenteral broad-spectrum cephalosporin with excellent activity against methicillin-resistant Staphylococcus aureus

1995 • 46 citations

In Vitro and In Vivo Activities of a Novel Cephalosporin, BMS-247243, against Methicillin-Resistant and -Susceptible Staphylococci

2002 • 46 citations

The peptidoglycan composition of a Staphylococcus aureus mutant selected for reduced methicillin resistance.

1993 • 41 citations

Therapeutic efficacy of BO-3482, a novel dithiocarbamate carbapenem, in mice infected with methicillin-resistant Staphylococcus aureus

1997 • 38 citations

Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus

1995 • 37 citations

Antibiotic Resistance in Staphylococcus Aureus Isolated at an Australian Hospital between 1946 and 1981

1985 • 37 citations

Efficacy of Ampicillin Plus -Lactamase Inhibitor (CP-45,899) in Experimental Endocarditis Due to Staphylococcus aureus

1981 • 36 citations

Clinical comparative study on the activity of cefamandole in the treatment of serious staphylococcal infections caused by methicillin-susceptible and methicillin-resistant strains

1986 • 34 citations

In Vivo Antibacterial Activity of S-3578, a New Broad-Spectrum Cephalosporin: Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Experimental Infection Models

2003 • 33 citations

Treatment of Experimental Staphylococcal Endocarditis Due to a Strain with Reduced Susceptibility In Vitro to Vancomycin: Efficacy of Ampicillin-Sulbactam

1999 • 29 citations

The Impact of Penicillinase on Cefamandole Treatment and Prophylaxis of Experimental Endocarditis Due to Methicillin‐ResistantStaphylococcus aureus

1998 • 28 citations

In Vitro and In Vivo Activities of Novel 2-(Thiazol-2-ylthio)-1β-Methylcarbapenems with Potent Activities against Multiresistant Gram-Positive Bacteria

2003 • 27 citations

Excellent activity of FK037, a novel parenteral broad-spectrum cephalosporin, against methicillin-resistant staphylococci.

1993 • 27 citations

In Vivo Antibacterial Activity of RWJ-54428, a New Cephalosporin with Activity against Gram-Positive Bacteria

2002 • 24 citations

Novel dithiocarbamate carbapenems with anti-MRSA activity

1998 • 22 citations

Comparison of the in-vitro and in-vivo efficacy of FK037, vancomycin, imipenem and nafcillin against staphylococcal species

1997 • 22 citations

Comparative in-vitro activity of carbapenem antibiotics against respiratory pathogens isolated between 1999 and 2000

2001 • 20 citations

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position

2001 • 18 citations

LB11058, a New Cephalosporin with High Penicillin-Binding Protein 2a Affinity and Activity in Experimental Endocarditis Due to Homogeneously Methicillin-Resistant Staphylococcus aureus

2004 • 18 citations

Importance of penicillinase production for activity of penicillin alone or in combination with sulbactam in experimental endocarditis due to methicillin-resistant Staphylococcus aureus

1996 • 15 citations

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546)

2003 • 14 citations

Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175)

2005 • 14 citations

In Vitro and In Vivo Antibacterial Activities of OPC-20011, a Novel Parenteral Broad-Spectrum 2-Oxaisocephem Antibiotic

1998 • 12 citations

Novel cephalosporins for the treatment of MRSA infections.

2002 • 11 citations

Species specificity of 2-aryl carbapenem-induced immunemediated hemolytic anemia in primates

1996 • 10 citations

In vitro Antibacterial Activity of TOC-50, a New Parenteral Cephalosporin against Methicillin Resistant <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>

1996 • 9 citations

Comparative efficacies of imipenem-cilastatin and vancomycin in experimental aortic valve endocarditis due to methicillin resistant Staphylococcus aureus

1988 • 9 citations

Therapeutic efficacy of J-111,225, a novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenem, against experimental murine systemic infections

2000 • 9 citations

Quality Control Guidelines for BAL9141 (Ro 63-9141), an Investigational Cephalosporin, When Reference MIC and Standardized Disk Diffusion Susceptibility Test Methods Are Used

2004 • 9 citations

“Intelligence coup” for drug designers: crystal structure of Staphylococcus aureus β-lactam resistance protein PBP2A

2003 • 8 citations

Stérilisation par 2 grammes d'Augmentin® des urines infectées à Staphylococcus aureus résistant à la méticilline

1993 • 6 citations

Deleted Work

1955 • 0 citations